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Reconstruction, modeling and use of genome-scale networks in biology

Colloquium

Bioengineering

Speaker: Bernhard O. Palsson, Ph.D.
Galletti Professor of Bioengineering, Professor of Pediatrics, and the Principal Investigator of the Systems Biology Research Group in the Department of Bioengineering
University of California, San Diego
Monday, January 26, 2015
4:00 PM - 5:15 PM
280 Brown College

Following the availability of full genome sequences in the mid 1990s, an effort was initiated to reconstruct, on a genome-scale, the biochemical reaction networks that underlie cellular functions. After 15 years of intense efforts, we now have highly curated network reconstructions, their experimental validation, and the generation of mathematical and modeling procedures available that allow the computation of cellular functions from genome- and bibliome-wide data sets. This effort has put a mechanistic basis into the most fundamental relationship in the life sciences; the genotype-phenotype relationship. This effort has started with simple organisms and the best characterized cellular functions and it is steadily growing in scope and biological complexity.

Biography of Bernhard O. Palsson, Ph.D.:
Bernhard Palsson is the Galetti Professor of Bioengineering, the Principal Investigator of the Systems Biology Research Group in the Department of Bioengineering, and a Professor of Pediatrics at the University of California, San Diego. Dr. Palsson has co-authored more than 390 peer-reviewed research articles and has authored three textbooks, with one more in press. His research includes the development of methods to analyze metabolic dynamics (flux-balance analysis, and modal analysis), and the formulation of complete models of selected cells (the red blood cell, E. coli, CHO cells, and several human pathogens). He sits on the editorial broad of several leading peer-reviewed microbiology, bioengineering, and biotechnology journals. He previously held a faculty position at the University of Michigan for 11 years and was named the G.G. Brown Associate Professor at Michigan in 1989, a Fulbright fellow in 1995, and an Ib Henriksen Fellow in 1996. He is the author of 40 U.S. patents, the co-founder of several biotechnology companies, and holds several major biotechnology awards. He received his PhD in Chemical Engineering from the University of Wisconsin, Madison. Dr. Palsson is a member of the National Academy of Engineering and is a Fellow of both the AAAS and the AAM.