M.S. Department of Fine and Precise Mechanics (1994) Warsaw University of Technology
Ph.D. Department of Mechatronics (2000) Warsaw University of Technology
Bio-imaging, microscopy, optical coherence tomography, imaging spectrometry, opto-mechanical design, optical testing, miniaturized optical and opto-mechanical systems, optical metrology.
Email: tkaczyk@rice.edu
Phone: 713-348-4362
Office: George R. Brown Hall, E100D
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Tomasz Tkaczyk
Assistant Professor in Bioengineering and Electrical and Computer Engineering
Research in Tkaczyk's Modern Optical Instrumentation and Bio-imaging Laboratory focuses on the development and application of novel imaging instruments and systems for the early detection and treatment of cancer. The compact size and high-performance capabilities of the bio-imaging tools developed in his lab have tremendous potential for point-of-care diagnostics in various clinical settings around the world.
To effectively advance his engineering research, Tkaczyk's group combines the newest technologies in:
1. Optics (grayscale lithography, laser printing, free form diamond turning, molding, etc.);
2. Opto-mechanics (LIGA, DRIE components);
3. Electronics (custom detectors);
4. Software (dedicated DSPs, new algorithms); and
5. Bio-chemical materials (solgel, gold nanoparticles, quantum dots).
Micro-optics research in bioengineering is a challenging task that requires a constant awareness of emerging technologies. Through collaborations with researchers in academic and industrial settings, Tkaczyk's efforts are leading to the design and testing of optical and mechanical technologies in:
- High-performance imaging micro-endoscopes that work with contrast agents and provide real-time cancer detection;
- Modern and inexpensive technologies that enable high performance and are adaptable to mass production; and
- High-throughput techniques like super-resolution or hyper-spectral imaging capabilities for optical screening devices that increase sensitivity and specificity for the detection of disease.
Tkaczyk's research has been supported by the National Cancer Institute, the National Institute of Health, National Science Foundation, Army Research Office, and Association for Research in Otolaryngology.
Selected Publications
Article
T.Tkaczyk, Miniature digital microscopy a powerful alternative for high-resolution biomedical imaging, BioOptics World, In Print 2008
J.D. Rogers, S. Landau, T. Tkaczyk, M.R. Descour, M.S. Rahman, R. Richards-Kortum, A.K¿rkk¿inen, T. Christenson, ¿Performance and imaging results for miniature integrated microendoscope¿ Journal of Biomedical Optics, 13(5), 054020-1-6 September/October (2008).
T.Tkaczyk, R.Kester, "Toward development of cost-effective
technologies for endo-microscopy", SPIE Newsletters, December 2008
Book chapter
T.Milster and T.Tkaczyk, book chapter: "Miniature and Micro-Optics"
in Handbook of Optics, McGraw Hill 3rd ed, In Press.
Refereed Article
R.T. Kester, T.Tkaczyk, M.R. Descour, T.Christenson, and R.Richards-Kortum "High numerical aperture microendoscope objective for a fiber confocal reflectance microscope." Opt. Express 15 (2007): 2409-2420.
Presentations
Invited Talk
"Confocal Microendoscopy." ECI International Conference on Advances in Optics for Biotechnology, Medicine and Surgery, Naples, FL. (June 2007)
"Minature Microscopy: New Dimensions and Possibilities." University of Illinois Urbana Champaign, Illinois. (4/2008)
"Modern technologies to build inexpensive, high performance micro-endoscopes for cellular imaging." Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications VIII, SPIE BIOS Conference, San Jose, CA. (January 2007)
Miniature Microscopy: New Dimensions and Possibilities" at University of Illinois, Urbana-Champaign, Bioenginnering in April 2008.
Other
"Minature Optical Systems within Hypodermic Tubing for In Vivo Diagnostics." OSA Annual Meeting, Rochester. (2008) With R. Kester, T. Christenson, R.Richards-Kortum.
Theses
Kelsey Rosbach, "Develop, evaluate, and optimize contrast agents to enhance the optical detection of oral cancer and its precursors." (2008).(Committee Member)
Ying Hu, "Fiber design for reflectance spectroscopy with nanoshells as contrast agents." (2008).(Committee Member)
Mohammed Rahman, "Low Cost Optical Imaging Systems for Early Detection of Oral Cancer." (2008).(Committee Member)
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