B.S. (1996) Duke University
M.S. (1998) University of Texas at Autin TX
Ph.D. (2001) University of Texas at Austin TX
nanotechnology, optical molecular imaging, cancer
Email: drezek@rice.edu
Phone: 713-348-3011
Office: E100A GRB Hall
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Rebekah Drezek
Professor of Bioengineering and Professor of Electrical and Computer Engineering
Research in my laboratory focuses on development of novel optical imaging technologies for in vivo assessment of tissue pathology. Projects emphasize design, prototyping, and clinical testing of optical tools for the detection, diagnosis, and monitoring of the molecular signatures of precancerous conditions and early malignancies. We approach our projects from an interdisciplinary perspective and actively collaborate with clinicians, molecular biologists, biochemists, and other researchers located within Rice and the Texas Medical Center.
In current medical practice, a final diagnosis of cancer or a precancerous condition is achieved only after histopathologic analysis of a directed biopsy. Biopsies are invasive, painful, and expensive. Moreover, many of the complex changes in cellular biochemistry and morphology that accompany the earliest stages of a disease process are not detectable through routine microscopic examination. Emerging photonics technologies provide the exciting opportunity to capitalize on subtle biophysical changes in tissue to provide quantitative, real-time, minimally invasive detection and diagnosis of disease.
In our laboratory, areas of current emphasis include:
1) development of novel optical spectroscopy and imaging instrumentation for tissue diagnosis
2) validating developed optical instrumentation through systematic studies using biological samples of progressively increasing complexity, beginning at the cellular level and culminating in small scale clinical trials
3) development of molecular specific optical contrast agents
4) experimental studies to elucidate the biophysical origins of measured optical signals
5) computational modeling of the interaction of light with biological tissue in order to understand the relationships between measured optical signals and underlying tissue biochemistry, morphology, and architecture
These research areas are linked in that knowledge of the biophysical origins of optical signals gained from the experimental and computational studies will provide guidance in optimizing the design of optical instrumentation and in meaningful interpretation of measured data. In addition, fundamental understanding of the mechanisms which create optical contrast will be used to develop strategies for the design of effective optical contrast agents which in turn will help generate data with increased clinical significance.
Selected Publications
Abstract
Lin, A., Halas, N., West, J., and Drezek, R. "Nanoengineered Contrast Agents for Biophotonics." Advances in Optical Technologies for Lasers, Medicine, and Surgery (Aug 2003).
Loo, C., Hirsch, L., Halas, N., West, J., and Drezek, R. "Molecular Specific Imaging Using Scattering Nanoshells." Advances in Optical Technologies for Lasers, Medicine, and Surgery (Aug 2003).
Pavlova, I., Sokolov, K., Drezek, R., Follen, M., and Richards-Kortum, R. "Microanatomical and Biochemical Basis of Normal and Precancerous Cervical Autofluorescence." Advances in Optical Technologies for Lasers, Medicine, and Surgery (Aug 2003).
Doran, T. and Drezek, R. "Automated Cellular Scattering Measurements." Rice Quantum Institute Summer Colloquium (Aug 2003).
Drezek, R. and Richards-Kortum, R. "Biophysical Origins of Cervical Tissue Fluorescence." Whitaker Foundation Annual Conference (Aug 2001).
Sokolov, K., Drezek, R., Gossage, K., Richards-Kortum, R. "Polarization Spectroscopy of Cervical Epithelium for Pre-Cancer Detection." Engineering Foundation Conference on Advances in Optics for Biotechnology, Medicine, and Surgery (Aug 1999).
Drezek, R., Zuluaga, A., Collier, T., Richards-Kortum, R. "Optical Contrast Agents." Engineering Foundation Conference on Advances in Optics for Biotechnology, Medicine, and Surgery (Aug 1999).
Drezek, R., Zuluaga, A., Dunn, A., Richards-Kortum, R. "Electromagnetic Modeling of Light Propagation Through Biological Tissue." Engineering Foundation Conference on Advances in Optics for Biotechnology, Medicine, and Surgery (Aug 1999).
Chen, J. and Drezek, R. "Optimal Spectroscopy for Tumor Margin Assessment in vivo." American Society of Lasers in Medicine and Surgery National Meeting. (April 2004).
Chen, J. and Drezek, R. "Optimal Methods for Autofluorescence Measurements of Cells." American Society of Lasers in Medicine and Surgery Annual National Meeting (April 2004).
Chen, J. and Drezek, R. "Finite Difference Time Domain Simulations of Light Scattering from Cells: Influence of Step Size, Boundary Conditions, and Incident Angle." Houston Society for Engineering in Medicine and Biology (April 2003).
Serhen, S., Drezek, R., Halas, N., and West, J. "Optically Active Nanoshells as Enhancing Agents for Laser Tissue Welding." Biomaterials (April 2002).
Richards-Kortum, R., Drezek, R., Brookner, C., Pavlova, I., and Follen, M. "Understanding the Biological Basis of Cervical Tissue Autofluorescence." OSA Biomedical 2000 Topical Meeting (April 2000).
Richards-Kortum, R., Drezek, R., Brookner, C., Pavlova, I., and Follen, M. "Fluorescence Imaging of Cervical Tissue Slices." European Conference on Genital Infections and Neoplasia (April 2000).
Chen, J., and Drezek, R. "Three-dimensional Finite Difference Time Domain Simulations of Light Scattering from Cells: Influence of Step Size, Boundary Conditions, and Incident Angle." Advances in Optical Technologies for Lasers, Medicine, and Surgery. Banff (AUG 2003).(Submitted)
Byers, S., West, J., Halas, N., and Drezek, R. "Nanoshells for Optical Coherence Tomography." CBEN Research Experiences for Undergraduates Poster Session (AUG 2003).(Submitted)
Pavolova, I., Sokolov, K., Drezek, R., Follen, M., and Richards-Kortum, R. "Micranatomical and Biochemical Basis of Normal and Precancerous Cervical Autofluorescence." Advances in Optical Technologies for Lasers, Medicine, and Surgery (AUG 2003).(Submitted)
Chen, J., and Drezek, R. "Finite Difference Time Domain Simulations of Light Scattering from Cells: Influence of Step Size, Boundary Conditions, and Incident Angle." Houston Society for Engineering in Medicine and Biology (APR 2003).(Submitted)
Chang, E., Colvin, V., Yu, W., and Drezek, R. "Quantitative Uptakes Studies of NIR Quantum Dots." (July 2005).
Loo, C., Lowery, A., Halas, N., West, J., and Drezek, R. "Immunotargeted Nanoshells for Integrated Imaging and Therapy of Cancer." (July 2005).
Loo, C., West, J., Halas, N., and Drezek, R. "Imaging Applications of Metal Nanoshells." Nanosummit 2003 (July 2003).
Drezek, R., Follen, M., and Richards-Kortum, R. "Understanding the Contributions of NADH and Collagen to Cervical Tissue Fluorescence Spectra." Engineering Foundation Conference on Advances in Optics for Biotechnology, Medicine, and Surgery (July 2001).
Brookner, C., Mitchell, M., Lotan, R., Boiko, I., Suzuki, S., Thomsen, S., Drezek, R., Heintzelman, D., and Richards-Kortum, R. "Cervical Autofluorescence Patterns in Living Tissue Slices." Engineering Foundation Conference on Advances in Optical Technologies for Medicine and Surgery (July 1997).
Halas, N., Bishnoi, S., Jackson, J., Lin, R., and Drezek, R. "anoshell based Raman sensing of biomaterials. Nano/biophotonics." (January 2005).(In Press)
Chen, J., and Drezek R. "Optimal Methods for Autofluorescence Measurements of Cells." (February 2005).
Lee, MH., West, J., Halas, N., and Drezek, R. "Nanoshells as Contrast Agents for Optical Coherence Tomography." (February 2005).
Chen, J. and Drezek, R. "Optimal Methods for Autofluorescence Measurements of Cells." Houston Society for Engineering in Medicine and Biology Annual Meeting (Feb 2004).
Lin, A., West, J., Halas, N., and Drezek, R. "Monte Carlo Investigation of Optical Signal Changes in Tissue After Nanoshell Application." Houston Society for Engineering in Medicine and Biology Annual Meeting (Feb 2004).
Kirkpatrick, N., Brewer, M., Drezek, R., and Utzinger, U. "Fluorescence Spectroscopy for Early Diagnosis of Ovarian Cancer." Biomedical Engineering Program (Feb 2004).
Fu, K. and Drezek, R. "Automated Goniometer for Cellular Light Scattering." Houston Society for Engineering in Medicine and Biology Annual Meeting (Feb 2004).
Loo, C., West, J., Halas, N., and Drezek R. "Nanoshell-Based Molecular Imaging of Breast Tissue." (August 2005).
Drezek, R. "Nanonengineered Contrast Agents for Cancer Imaging." (August 2005).
Chen, J. and Drezek, R. "Three Dimensional Finite Difference Time Domain Simulations of Light Scattering from Cells: Influence of Step Size, Boundary Conditions, and Incident Angle." Advances in Optical Technologies for Lasers, Medicine, and Surgery (Aug 2003).
Byers, S., West, J., Halas, N., and Drezek, R. "Nanohsells for Optical Coherence TOmography." CBEN Research Experiences for Undergraduates Poster Session (Aug 2003).
Yu, W., Drezek, R., and Colvin, V. "High Quality Semiconductor and Magnetic Nanoparticles and Their Applications." (2005).
Sun, JT, and Drezel, R. "Immunotargeted NIR Emissive PbS Quantum Dots for Live Cell Imaging." (2006).(Submitted)
Wargo, M., Hafner, J., West, J., and Drezek R "Immuntargeted Nanorods for Optical Molecular Imaging of Cancer." (2006).(Submitted)
Sun, J., Chang, E., Colvin, V., West, J., and Drezek, R. "Gold Quenched Quantum Dot NIR Optical Probes for Protease Imaging." Advances in Optics for Biotechnology, Medicine, and Surgery (7/2005).
Hsu, K. and Drezek, R. "Inversion Models for Quantitative Extraction of Biochemical Features from in vivo Fluorescence Spectra." Summer Conference on Biomedical Engineering (6/2005).
Loo, C., Lowery, A., Halas, N., West, J., and Drezek, R. "Immunotargeted Nanoshells for Integrated Imaging and Therapy of Cancer." DOD Era of Hope Annual Breast Cancer Conference (6/2005).
Hsu, K., Brewer, M., Utzinger, U., and Drezek, R. "Interpreting Ovarian Cancer Fluorescence Spectra." (2006).
Hsu, K., and Drezek, R. "Inversion Models for Quantitative Extraction of Biochemical Features from In Vivo Tissue Fluorescence Spectra." (2006).
Loo, C., Lowery, A., Halas, N., West, J., and Drezek, R. "Immunotargeted Nanoshells for Integrated Imaging and Therapy of Cancer." First Annual IBB Symposium (6/2005).
Utzinger, U., Kirkpatrick, N., Brands, W., Brewer, M., and Drezek, R. "Fluorescence Spectroscopy of Ovarian Cancer." European Conference on Biomedical Optics (6/2005).
Drezek, R. "Nanoengineered Contrast Agents for Optical Molecular Imaging of Cancer." (2006).
Lin, A., and Drezek R. "Nanoshell Reflectance." (2006).
Lee, M.H., Gobin, A., West, J., and Drezek, R. "Nanoshells Enable Molecular Specific OCT Contrast." (2006).
"Nanoshells for Imaging and Therapy of Breast Cancer." (2006).
Nammalvar, V., Wang, A. West, J., and Drezek, R. "Oblique Fiber Probe Geometry Enables Two Order of Magnitude Contrast Enhancement for Detection of Nanoshells in Tissue." (2006).(Submitted)
Anant Agrawal, Stanley Huan, Alex Wei Haw Lin, Min-Ho Lee, Jennifer Kehlet Barton, Rebekah A. Drezek, and T. Joshua Pfefer "Optical coherence tomography signal enhancement with gold nanoshells." (2006).
Nammalvar, N., and Drezek, R. "PLS-Based Algorithm Development for Fluorescence Imaging of Chemoprevention." (2006).
Lin, A., Lewinski, N., Lee, M.H., and Drezek, R "Reflectance Spectroscopy of Gold Nanoshells: Computational Predictions and Experimental Measurements." Journal of Nanoparticle Research, DOI 10.1007/s11051-66-9136-z (2006).
Gulati, A., and Drezek, R. "Nanorods for Integrated Imaging and Therapy of Cancer." (2007).
Drezek, R. "Nanoengineered Contrast Agents for Cancer Imaging." Beckman Foundation Annual Conference (8/2005).
Fu, K., Halas, N., West, J., and Drezek, R. "Polarized Light Scattering Measurements of Metal Nanoshells." RQI Symposium (8/2004).
Drezek, R. "Optical Spectroscopy for Tumor Margin Identification." Whitaker Foundation Annual Conference (8/2004).
Wang, A. and Drezek, R "A Fiber Probe for the Separation of Epithelial and Stromal Optical Signals." (2006).(Submitted)
Zhu, M., Chang, E., and Drezek, R. "A General Strategy for Direct Surface Modification and Functionalization of Semiconductor Quantum Dots." (2006).(Submitted)
Chang, E., Colvin, V., Yu, W., and Drezek, R. "Quantitative Uptake Studies of NIR Quantum Dots." Advances in Optics for Biotechnology, Medicine, and Surgery (7/2005).
Appiah, B., and Drezek, R. "A Mathematical Algorithm to Extract Biophysical Parameters from Ovarian Fluorescence Spectra." (2006).(Submitted)
Chang, E. and Drezek, R. "A Novel siRNA Dual Imaging/Therapy Molecular Beacon." Proceedings of the National Academy of Science (2006).(Submitted)
Fu, K., and Drezek, R. "A Scatter-Based Method for Quantifying Nanoparticle Binding to Surface Markers." (2006).(Submitted)
Chang, E., Miller, J., Sun, JT, Colvin, V., West, J., and Drezek, R. "Activatavle Probes for Protease Imaging." (2006).(Submitted)
Chang, E., Miller, J., Sun, JT, Colvin, V., West, J., and Drezek, R "Activatavle Probes for Protease Imaging.." (2006).
Wang, A. and Drezek, R. "Oblique Fiber Probes for Depth Sensitive Reflectance Spectroscopy." Advances in Optics for Biotechnology, Medicine, and Surgery (7/2005).
Lee, M. H., Halas, N., West, J., and Drezek, R. "Nanoshells for 1300 nm Optical Coherence Tomography." Advances in Optics for Biotechnology, Medicine, and Surgery (7/2005).
Loo, C., Lowery, A., Halas, N., West, J., and Drezek, R. "Immunotargeted Nanoshells for NIR RCM Imaging." National MD/PhD Annual Conference (7/2005).
Loo, C., Lowery, A., Halas, N., West, J., and Drezek, R. "Immunotargeted Nanoshells for Integrated Imaging and Therapy of Cancer." Advances in Optics for Biotechnology, Medicine, and Surgery (7/2005).
Wargo, M., Hafner, J., and Drezek, R. "Immunotargeted Nanorods for Optical and Molecular Imaging of Cancer.." Advances in Optics for Biotechnology, Medicine, and Surgery (7/2005).
Lowery, A., Halas, N., Drezek, R., and West, J. "Antibody Targeted Nanoshells for Cancer Therapy." 22nd Houston Society for Engineering in Biology and Medicine Annual Meeting (2/2005).
Sun, J., Utzinger, U., and Drezek, R. "Diffusion Theory Based Inverse Modeling of Tissue Reflectance Spectra." 22nd Annual Houston Society for Engineering in Medicine and Biology Annual Meeting (2/2005).
Fu, K., Halas, N., and Drezek, R. "Experimental Measurement of Angular Dependent Light Scattering from Nanoshells." 22nd Annual Houston Society for Engineering in Medicine and Biology Annual Meeting (2/2005).
Loo, C., Lowery, A., Hirsch, L., West, J., Halas, N., and Drezek, R. "Nanoshell-Enabled Molecular Imaging." 22nd Houston Society for Engineering in Medicine and Biology Annual Meeting (2/2005).
O'Neal, P., Gobin, A., Bayazitoglu, Y., Halas, N., and Drezek, R. "Nanoshells as an Exogenous Absorber for Laser Tissue Welding." 22nd Houston Society for Engineering in Medicine and Biology Annual Meeting (2/2005).
Chen, J. and Drezek, R. "Optimal Methods for Autofluorescence Measurements of Cells." 22nd Houston Society for Engineering in Medicine and Biology Annual Meeting (2/2005).
Chang, E., Colvin, V., and Drezek, R. "Quantum Dots for Biomedical Imaging." 22nd Houston Society for Engineering in Medicine and Biology Annual Meeting (2/2005).
Yu, W., Chang, E., Drezek, R., and Colvin, V. "Synthesis, Water Solubility, and Biomedical Applications of Nanocrystals." 22nd Annual Houston Society for Engineering in Medicine and Biology Annual Meeting (2/2005).
Drezek, R., Zuluaga, A., Dunn, A., and Richards-Kortum, R. "Light Scattering from Cancerous and Non-Cancerous Cells." OSA Annual Meeting (Sept 1999).
Chang, E., Miller, J., Sun, JT, Colvin, V., West, J., and Drezek, R. "Gold Quenched Quantum Dot NIR Optical Probes for Protease Imaging." (October 2005).
Bishnoi, S., Jackson, J., Levin, C., Lin, A., Drezek, R., and Halas, N. "SERS Sensing with Nanoshells." Biophotonics West (1/2005).
Lowery, A., Loo, C., O'Neal, P., Halas, N., Drezek, R., and West, J. "Cancer Imaging and Therapy Using Gold Nanoshells." Biomedical Engineering Society Annual Meeting (10/2004).
Chang, E., Miller, J., Sun, J. T., Colvin, V., West, J., and Drezek, R. "Gold Quenched Quantum Dot NIR Optical Probes for Protease Imaging." Biomedical Engineering Society Annual Meeting (10/2004).
Gobin, A., Halas, N., Drezek, R., and West, J. "Laser Welding Using Nanoshells as an Exogenous Absorber." Biomedical Engineering Society Annual Meeting (10/2004).
Lee, M. H., West, J., Halas, N., and Drezek, R. "Nanoengineered Optical Contrast Agents." Nanodays (10/2004).
Loo, C., West, J., Halas, N., and Drezek, R. "Nanoshell Bioconjugates in Imaging." Nanodays (10/2004).
Drezek, R. "Nanoshells in Imaging." Nanodays (10/2004).
West, J., Hirsch, L., Lowery, A., Drezek, R., and Halas, N. "Diagnostic and Therapeutic Applications of Nanoshells." American Institute of Chemical Engineers Annual Meeting (11/2004).
Loo, C., Lowery, A., Hirsch, L., West, J., Halas, N., and Drezek, R. "Nanoshell-Enabled Molecular Imaging." Center for Biomedical Engineering Annual Meeting (12/2004).
Lee, M. H., West, J., Halas, N., and Drezek, R. "Nanoshells as Contrast Agents for Optical Coherence Tomography." Center for Biomedical Engineering Annual Meeting (12/2004).
Chang, E., Colvin, V., Drezek, R. "Quantum Dots for Biomedical Imaging." Center for Biomedical Engineering Annual Meeting (12/2004).
Drezek, R. and Stetten, G. "Adaptive Shape Detection in Matrix-Array Ultrasound Cardiac Data." National Science Foundation Site Visit (1995).
Drezek, R. and Stetten, G. "Automated Heart Chamber Volume Determination Using Real-Time 3D Ultrasound Data." NSF/ERC in Emerging Cardiovascular Technologies Annual Meeting with Industry (1995).
Drezek, R. and Stetten, G. "Automated Boundary Detection Using Elliptical Fourier Series in 3D Ultrasound Cardiac Data." 3rd International Conference on Information Processing and Computational Intelligence (1996).
Lee, M. H., West, J., Halas, N., and Drezek, R. "Nanoengineered Optical Contrast Agents." Nanosummit.
Pfefer, J., Agrawal, A., and Drezek, R. "Fiber Optic Probe Design for Fluorescence Spectroscopy." Food and Drug Administration.
Lowery, A., Hirsch, L., O'Neal, P., Halas, N., Drezek, R., and West, J. "Nanoshell-Modulated Photothermal Cancer Therapy." Biomaterials 2004 (2004).
Stetten, G., Ohazama, C., and Drezek, R. "The Swath Algorithm for Shape Detection in Matrix-Array Ultrasound Data." 21st International Symposium on Ultrasonic Imaging and Tissue Characterization (June 1996).
Drezek, R., Dunn, A., and Richards-Kortum, R. "Light Scattering from Cells: FDTD Simulations and Goniometric Measurements." Gordon Research Conference on Lasers in Medicine and Biology (June 1998).
Drezek, R. and Richards-Kortum, R. "Light Scattering from Biological Cells: Simulations, Measurements, and Implications." Whitaker Foundation Annual Conference (June 1999).
Sokolov, K., Drezek, R., Gossage, K., Richards-Kortum, R. "Quantitative Optical Techniques for Pre-Cancer Detection: Reflectance Spectroscopy with Polarized Light." NASA/NCI Joint Conference on Sensors for Bio-Molecular Sensors (June 1999).
Drezek, R., Collier, T., Zuluaga, A., Richards-Kortum, R. "Laser Scanning Confocal Microscopy of Cervical Tissue Before and After Application of Acetic Acid." 31st Annual Flexi Rutledge Society Meeting (June 2000).
Utzinger U, Kirkpatrick N, Brands W, Brewer M, and Drezek R. "Fluorescence spectroscopy of ovarian Cancer." (June 2005).
Hsu, K., and Drezek, R. "Inversion Models for Quantitative Extraction of Biochemical Features from In Vivo Fluorescence Spectra." (June 2005).
Fu, K. and Drezek, R. "Automated Goniometer for Cellular Light Scattering." 2nd Annual Bioengineering Poster Competition (March 2004).
Loo, C., West, J., Halas, N., and Drezek, R. "Nanoshell-Enabled Modular Imaging." 2nd Annual Bioengineering Poster Competition (March 2004).
Lee, M. H., West, J., Halas, N., and Drezek, R. "Nanoshells as Contrast Agents for Optical Coherence Tomography." 2nd Annual Bioengineering Poster Competition (March 2004).
Drezek, R., Follen, M., and Richards-Kortum, R. "Fluorescence and Reflectance Spectroscopy of Cervical Tissue." M.D. Anderson Cancer Center Trainee Recognition Conference (May 2002).
Drezek, R., Sokolov, K., Edwards, A., Follen, M., and Richards-Kortum, R. "Understanding the Contributions of NADH and Collagen to Cervical Tissue Fluorescence Spectra." M.D. Anderson Cancer Center Trainee Recognition Conference (May 2002).
Utzinger, U., Kirkpatrick, N., Drezek, R., and Brewer, M. "Optical Signals of the Ovary." (May 2004).
Loo, C., West, J., Halas, N., and Drezek, R. "Metal Nanoshells: Applications Towards In Vivo Molecular Imaging." Nanodays (OCT 2003).(Submitted)
Chang, E., Miller, J., Sun, JT, Colvin, V., West, J., and Drezek, R. "Gold Quenched Quantum Dot NIR Optical Probes for Protease Imaging." (October 2005).
Utzinger, U., Brands, M., Brewer, M., and Drezek, R. "Fluorescence Spectroscopy of Ovarian Cancer." (October 2005).
Lin, A., Loo, C., Hirsch, L., Halas. N., West, J., and Drezek, R. "Nanoshells for Cancer Imaging and Therapy." (October 2004).(In Press)
Loo, C., West, J., and Drezek, R. "Nanoshells for Real-Time NIR RCM-Based Molecular Imaging." Biomedical Engineering Society Annual Meeting (Oct. 2005).
Loo, C., Hirsch, L., West, J., Halas, N., and Drezek, R. "Targeted Breast Cancer Imaging Using Scattered Nanoshells." Nanodays (Oct 2003).
Utzinger, U., Brewer, M., and Drezek, R. "Optical Imaging of the Ovary." Biomedical Engineering Society Annual Meeting (Oct 2003).
Lin, A., West, J., Halas, N., and Drezek, R. "Nanoengineered Contrast Agents for Biophotonics." Nanoengineered Contrast Agents for Biophotonics (Oct 2003).
Lin, A., West, J., Halas, N., and Drezek, R. "Nonoparticle-Based Contrast Agents for Biophotonics." Nanodays Conference (Oct 2002).
Loo, C., West, J., Halas, N., and Drezek, R. "Targeted Breast Cancer Imaging Using Scattering Nanoshells." Nanodays (OCT 2003).(Submitted)
Utzinger, U., Brewer, M., and Drezek, R. "Imaging of Endogenous Contrast for in situ Ovarian Cancer Diagnosis." Frontiers in Optics/Lasers in Science XIX (2003).
Lin, A., West, J., Halas, N., and Drezek, R "Nanoengineered Contrast Agents for Biophotonics." Nanodays (OCT 2003).(Submitted)
Article
Bickford, L., Sun, J., Fu, K., Lewinski, N., Nammalvar, V., Chang, J., Drezek, R. "Enhanced Multispectral Imaging of Live Breast Cancer Cells Using Immunotargeted Gold Nanoshells and Two-Photon Excitation Microscopy." Nanotechnology, 19 (31) (2008): 315102.
Lewinski, N, Zhu, H, and Drezek, R. "Evaluating Strategies for Risk Assessment of Nanomaterials." In Nanotoxicity: From In Vitro to In Vivo Models to Health Risks (2008).(In Press)
Lewinski, N., Colvin, V., and Drezek, R. "Cytotoxicity of Nanoparticles." Small, 4(1) (2008): 26-49.
Lewinski, N, Zhu, H, and Drezek, R. “Evaluating Strategies for Risk Assessment of Nanomaterials.” In Nanotoxicity: From In Vitro to In Vivo Models to Health Risks. John Wiley. 459-498 (2009).
Bickford, L., Chang, J., Fu, K., Sun, J., Hu, Y., Gobin, A., Yu, TK, and Drezek, R. "Evaluation of Immunotargeted Gold Nanoshells as Rapid Diagnostic Imaging Agents for HER2+ Breast Cancers." Nanobiotechnology (2008).(In Press)
Bickford, L., Drezek, R. et al. "Biomedical Applications of Gold Nanoshells." Biomedical Nanotechnology: Materials for Nanomedicine (2008).(In Press)
Sun, J., Fu, K., Zhu, MQ, Bickford, L., Post, E., and Drezek, R. “Near-infrared quantum dots for fluorescence tissue imaging” Current Nanoscience, 5 (2), 160-166 (2009).
Fu, K., Sun, J., Bickford, L., Lin, A., Halas, N., Yu, TK, and Drezek, R. "Measurement of Immunotargeted Plasmonic Nanoparticle Cellular Binding: A Key Factor in Optimizing Diagnostic Efficacy." Nanotechnology, 19 (4) (2008): 045103.
Bickford, L., Drezek, R. et al. “Biomedical Applications of Gold Nanoshells.” Biomedical Nanotechnology: Materials for Nanomedicine, edited by Mansoor M. Amiji, RPh, PhD, and Vladimir P. Torchilin, DSc, PhD (Pan Stanford Publishing). In press (2009).
Sun, J., Fu, K., Zhu, MQ, Bickford, L., Post, E., and Drezek, R. "Near-infrared quantum dot cintrast agents for fluorescence tissue imaging: A phantom study." Current Nanoscience (2008).(In Press)
Zhang, S., Gao, J., Buchholz, T., Wang, Z., Salehpour, M., Drezek, R., and Yu, TK. "QuantifyingTumor-Selective Radiation Dose Enhancements Using Gold Nanoparticles: A Monte Carlo Simulation Study." Biomedical Microdevices. 1-9. (2009).
Cui, J., Jun-Bing, F., Zhao, T., Wang, A., Drezek, R., and Zhu, MQ. "Real Time Monitoring and Scale-Up Synthesis of Concentrated Gold Nanorods." Journal of Biomedical Nanotechnology 5:1-6 (2009).
Hu, Y., Fleming, R., and Drezek, R. "Optical properties of gold-silica-gold multilayered nanoshells." Optics Express, Vol 16(24) (2008): 19579.
Hleb, E., Hu, Y., Drezek, R., Hafner, J., and Lapotko, D. "Photothermal bubbles as optical scattering probes for imaging live cells." Nanomedicine (2008).(In Press)
Rostro-Kohanloo, B., Bickford, L., Payne, C., Day, E., Anderson, L., Zhong, M., Zhong, Lee, S., Mayer, K., Zal, T., Adam, L., Dinney, C., Drezek, R., West, J., and Hafner, J. "Stabilization and Targeting of Surfactant-Synthesized Gold Nanorods." Nanotechnology. 20:434005 (2009).
Culver, J., Drezler, W., Drezek, R., Georgakoudi, I., Hillman, E., and Richards-Kortum, R. "Topics in Biomedical Optics: introduction to the feature issue." Applied Optics. 48(10). April (2009).
Wargo, M., Halas, N., West, J., and Drezek, R. "Integrated Imaging and Therapy of Cancer Using Immunotargeted Nanomaterials." Expert Opinion on Drug Delivery (January 2006).
Lin, A., Halas, N., West, J., and Drezek, R. "NIR Reflectance Properties of Gold Nanoshells." (June 2006).
Hu Y, Nieminen TA, Bickford LR, Drezek RA. "Concentric Sphere Mie Theory Model: Applications to Nanoshell Spectra Prediction and Design of Anti-Reflection Coatings for Optical Traps." (March 2008).
Bickford, L., Drezek, R.*, and Yu, TK*. *equal contributors and corresponding authors. Silica-gold nanoshells as potential intraoperative molecular probes for HER2-overexpression in ex vivo breast tissue using near-infrared reflectance confocal microscopy. Breast Cancer Research and Treatment. Online first (2009).
Gobin, A., Halas, N., O¿Neal, P., Watkins, D., Halas, N., Drezek, R. and West, J. "Near Infrared Laser Tissue Welding Using Nanoshells as an Exogenous Absorber." Lasers in Surgery and Medicine, 37: 123-129.
Lin, A., Lewinski, N., West, J., Halas, N., and Drezek, R. "Computational Analysis of Nanoshells as Optical Contrast Agents for Early Precancer Detection." Journal of Biomedical Optics (November/December 2005).(In Revision)
Drezek, R., Collier, T., MacAulay, C., Follen, M., and Richards-Kortum, R. "Light Scattering from Cervical Cells Throughout Neoplastic Progression: Influence of Nuclear Size, DNA Content, and Chromatin Texture." Journal of Biomedical Optics, 8 (2003): 7-16.
1. Drezek, R., Collier, T., MacAulay, C., Follen, M., and Richards-Kortum, R. "Light Scattering from Cervical Cells Throughout Neoplastic Progression." Virtual Journal of Biological Physics Research, 5 (2003): 2.
Drezek, R., Collier, T., MacAulay, C., Follen, M., and Richards-Kortum, R. "Light Scattering from Cervical Cells Throughout Light Scattering from Cervical Cells Throughout Neoplastic Progression: Influence of Nuclear Size, DNA Content, and Chromatin Texture." Journal of Biomedical Optics, 8 (2003): 7-16.
Halas, N., O'Neal, P., Watkins, D., Halas, N., Drezek, R., and West, J. "Near Infrared Laser Tissue Weslding Using Nanoshells as an Exogenous Absorber." Lasers in Surgery and Medicine (2005).(In Press)
Pfefer, J., Matchette, S., and Drezek, R. "Influence of Illumination-Collection Geometry on Fluorescence Spectroscopy in Multi-layered Tissue." Medical and Biological Engineering and Computing (2003).(In Revision)
Pfefer, J., Agrawal, A., and Drezek, R. "Oblique-incidence illumination and collection for depth-sensitive fluorescence spectroscopy." Journal of Biomedical Optics, 10(4): 044016 (2005).
Fu, K., Sun, J., Lin, A., Halas, N., and Drezek R. "Polarized Angular Dependent Light Scattering Properties of Bare and PEGylated Gold Nanoshells." Physical Review E (2005).(Submitted)
Drezek, R. "Review of Autofluorescence and Diffuse Reflectance Properties of Malignant and Benign Breast Tissue." Breast Diseases, 3 (2004): 256-257.
Drezek, R. "Review of Autofluorescence and Diffuse Reflectance Properties of Malignan and Benign Breast Tissue." Breast Diseases, 3 (2004): 256-257.
Chen, J. and Drezek, R. "Optimized Three-dimensional FDTD Modeling of Cellular Light Scattering: Influence of Boundary Conditions, Step Size, and Incident Angle." Optics Express (2004).(Submitted)
Chang, E., Miller, J. Sun, J. Drezek, R*, and West, J* "Quenched Quantum Dots as Protease Imaging Probes." Biochemical and Biophysical Research Communications, 334 (2005): 1317-1321.
Drezek, R. "Review of Dynamic Optical Breast Imaging." Breast Diseases (2005).(In Press)
Chang, E., Wargo, M., Chen, J., Lin, A., Loo, C., and Drezek R. "Optical Imaging of Cancer." Critical Reviews in Biomedical Engineering (2004).(In Revision)
Zuluaga, A., Drezek, R., Follen, M., and Richards-Kortum, R. "How Simple Chemicals Can Act as Optical Contrast Agents for Confocal Reflectance Imaging." Journal of Biomedical Optics, 7 (2002): 398-403.
Zhu, M., Chang, E., and Drezek, R "A General Strategy for Direct Surface Modification and Functionalization of Semiconductor Quantum Dots." Journal of Materials Chemistry (2006).(In Press)
Drezek, R., West, J., and Halas, N. "Optical Technologies for Functional and Molecular Imaging of the Breast." Breast Diseases, 14 (2003): 18-20.
Chen, J., and Drezek, R. "Optimized Three-dimensional FDTD Modeling of Cellular Light Scattering: Influence of Boundary Conditions, Step Size, and Incident Angle." Optics Express (2003).(In Revision)
Drezek, R., Faupel, M., Pitris, C., Feld, M., Brewer, M., Richards-Kortum, R., and Follen, M. "Optical Imaging for the Detection of Cervical Precancers In Vivo." Cancer, 98 (2003): 2015-2027.
Pavlova, I., Sokolov, K., Drezek, R., Malpica, A., Follen, M., and Richards-Kortum, R. "Microanatomical and Biochemical Origins of Normal and Precancerous Cervical Tissue Autofluorescence Using Laser Scanning Confocal Fluorescence Microscopy." Photochemistry and Photobiology, 77 (2003): 550-555.
Chang, S., Arifler, D., Drezek, R., Follen, M., and Richards-Kortum, R. "Validation of Analytical Model to Describe Fluorescence Spectra of Normal and Pre-Neoplastic Epithelial Tissue." Journal of Biomedical Optics, 9(3) (2004): 511-522.
Chang, S., Arifler, D., Drezek, R., Follen, M., and Richards-Kortum, R. "Validation of Analytical Model to Describe Fluorescence Spectra of Normal and Pre-Neoplastic Epithelial Tissue: Comparison of Mote Carlo Simulations and Clincial Measurements." Journal of Biomedical Optics, 9 (2004): 511-522.
Loo, C., Lin, A., Hirsch, L., Lee, M., Barton, J., Halas, N., West, J., and Drezek, R. "Chapter 12: Diagnostic and Therapeutic Applications of Metal Nanoshells." Nanofabrication for Biomedical Applications (2005): 327-342.
Chang, S., Arifler, D., Drezek, R., Follen, M., and Richards-Kortum, R. "Validation Analytical Model to Describe Fluorescence Spectra of Normal and Pre-Neoplastic Epithelial Tissue: Comparison with Monte Carlo Simulations and Clinical Measurements." Journal of Biomedical Optics (2003).(In Revision)
Drezek, R. "Review of Fluorescence Lifetime Imaging of Unstained Tissue." Breast Diseases, 14 (2004): 395.
Wang, A., Bender, J., Utzinger, U., and Drezek, R. "Depth Sensitive Reflectance Measurements Using Obliquely Oriented Fiber Optics Probes." Journal of Biomedical Optics, 10 (4) 044017 (2005).
Drezek, R. "Review of Flourescence Lifetime Imaging of Unstained Tissue." Breast Diseases, 14 (2004): 395.
Kirkpatrick, K., Zhou, C., Brewer, M., Brands, W., Drezek, R., and Utzinger, U. "Endogenous Fluorescence Spectroscopy of Cell Suspensions for Chemopreventive Drug Monitoring." Photochemistry and Photobiology (2005).
1. Pavlova, I., Sokolov, K., Drezek, R., Malpica, A., Follen, M., and Richards-Kortum, R. "Microanatomical and Biochemical Origins of Normal and Precancerous Cervical Tissue Autofluorescence Using Laser Scanning Confocal Fluorescence Microscopy." Photochemistry and Photobiology, 77 (2003): 550-555.
Loo, C., Lowery, A., Halas, N., West, J., and Drezek, R. "Immunotargeted Nanoshells for Integrated Imaging and Therapy of Cancer." Nano Letters, 5 (2005): 709-711.
Sun, JT, and Drezek, R. "Influence of Fiber Probe Geometry on Applicability of Diffusion Theory Based Spectral Inversion Methods." Medical and Biological Engineering and Computing (2005).(Submitted)
Chang E., Yu W., Colvin C., and Drezek R. "Influence of Surface Coatings on Intracellular Quantum Dot Delivery." Controlled Release (2005).(Submitted)
Fu, K., Sun, J., Lin, A., Halas, N., and Drezek R "Polarized Angular Dependent Light Scattering Properties of Bare and PEGylated Gold Nanoshells." Current Nanoscience (2006).(In Press)
Loo, C., Hirsch, L., West, J., Halas, N., and Drezek, R. "Molecular Imaging in Living Cells Using Nanoshell Bioconjugates." Optics Letters (2004).
Drezek, R., Brookner, C., Pavlova, I., Follen, M., and Richards-Kortum, R. "Autofluorescence Microscopy of Fresh Cervical Tissue Sections Reveals Alterations in Tissue Biochemistry with Dysplasia." Photochemistry and Photobiology, 73 (2001): 636-641.
Wang, A., Nammalvar, V., and Drezek, R. "Spectral Modeling of Angled Fiber Probe Geometries." Journal of Biomedical Optics (2006).(Submitted)
Sun, JT, Fu, K, Wang, A, Utzinger, U, and Drezek, R "The influence of fiber optic probe geometry on the applicability of inverse models of tissue reflectance spectroscopy: computational models and experimental measurements." Applied Optics, 31 (2006): 652-662.
Yu, W., Chang, E., Drezek, R., and Colvin, V. "Water-Soluble Quantum Dots." Biochemical and Biophysical Research Communications, 384 (2006): 781-786.
Stetten, G. and Drezek, R "Active Fourier Contour Applied to Real-Time 3-D Ultrasound of the Heart." International Journal of Image and Graphics, 1 (2001): 647-658.
Coghlan, L., Utzinger, U., Drezek, R., Brookner, C., Richards-Kortum, R., and Follen, M. "Optimal Excitation Wavelengths for Detection of Squamous Intraepithelial Neoplasia: Results from an Animal Model." Optics Express, 7 (2000): 436-446.
Lowery, A., Loo, C., Halas, N., West, J., and Drezek, R. "Integrated Imaging and Therapy of Cancer Using Nanoshell Bioconjugates." Nature Biotechnology (2004).(Submitted)
Drezek, R., Collier, T., Brookner, C., Lotan, R., Malpica, A., Follen, M., and Richards-Kortum, R. "Laser Scanning Confocal Microscopy of Cervical Tissue Before and After Application of Acetic Acid." American Journal of Obstetrics and Gynecology, 182 (2000): 1135-1139.
Drezek, R., Dunn, A., and Richards-Kortum, R. "A Pulsed Finite-Difference Time-Domain (FDTD) Method for Calculating Light Scattering from Biological Cells Over Broad Wavelength Ranges." Optics Express, 6 (2000): 147-157.
Sokolov, K., Drezek, R., Gossage, K., and Richards-Kortum, R. "Reflectance Spectroscopy with Polarized Light: Is it Sensitive to Cellular and Nuclear Morphology?." Optics Express, 13 (1999): 302-317.
Drezek, R., Dunn, A., and Richards-Kortum, R. "Finite-Difference Time-Domain Computations and Goniometric Measurements of Light Scattering from Cells." Applied Optics, 38 (1999): 3651-3661.
Pfefer, J., Matchette, S., and Drezek, R. "Influence of Illumination-Collection Geometry on Fluorescence Spectroscopy in Multilayered Tissue." Medical and Biological Engineering and Computing, 42 (2004): 66-673.
Wang, A., Bender, J., Utzinger, U., and Drezek, R. "Depth Sensitive Reflectance Measure ments Using Obliquely Oriented Fiber Optics probes." Journal of Biomedical Optics (2004).(In Revision)
Pfefer, J., Agrawal, A., and Drezek, R. "Computational Analysis of Angled Illumination and Collection Geometries for Sensitive Detection of Fluorescence in biological Tissues." Journal of Biomedical Optics (2004).(In Revision)
Pfefer, J., Agrawal, A., and Drezek, R. "Computational Analysis of Angled Illumination and Collection Geometries for Sensitive Detection of Fluorescence in Biological Tissues." Journal of Biomedical Optics (2004).(In Revision)
Hirsch, L., Drezek, R., Halas, N., and West, J. "Biomedical Applications of Nanoshells." Encyclpedia of BioMEMs and Bionanotechnology (2004).(In Press)
4 . (
Loo, C., Hirsch, L., Barton, J., Halas, N., West, J., and Drezek, R. "Nanoshell-Enabled Photonics-Based Cancer Imaging and Therapy." Technology in Cancer Research and Treatment, 3 (2004): 33-40.
Nammalvar, V., Hsu, K., Utzinger, U.*, Brewer, M.*, and Drezek R.* "Characterization of Chemopreventive Drug Activity Using Fluorescence Spectroscopy and Chemometric Analysis." Journal of Biomedical Optics (2006).(In Revision)
Agarwal, A., Lin, A. Lee, MH, Barton, J., Drezek, R, and Pfefer, J. "Contrast Enhancement in Optical Coherence Tomography Using Gold Nanoshells: Results from a Phantom Study." Journal of Biomedical Optics, 11 (2006): 041121.
Chang, E., Thekkek, N., Colvin, V. and Drezek, R "Evaluating Quantum Dot Cytotoxicity Based on Extracellular and Intracellular Exposure." Small, 2 (2006): 1412-1417.
W.W. Yu, E. Chang, J.C. Falkner, C.M. Sayes, A.M. Al-Somali, J. Zhang, R. Drezek, V.L. Colvin "Facile method to make stable, bright water-soluble quantum dots for biological application." J. Am. Chem. Soc (2006).(Submitted)
Lee, M., West, J., Halas, N., Barton, J., and Drezek, R. "Nanoengineered Contrast Agents for Optical Coherence Tomography." Optics Letters (2004).(Submitted)
Loo, C., Hirsch, L., West, J., Halas, N., and Drezek, R. "Molecular Imaging in Living Cells Using Nanoshell Bioconjugates." Optics Letters (2004).(In Press)
Lee, M., Gobin, A., Halas, N., West, J., and Drezek, R "In Vivo Assessment of Nanoshells as a Contrast Agent for Optical Coherence Tomography." International Journal of Nanomedicine (2006).(Submitted)
Pfefer, J., Agrawal, A., and Drezek, R. "Influence of Probe Design on Time-Resolved Layer Fluorescence in Tissue." Optics Letters (2006).(Submitted)
Wargo, M., Halas, N., West, J., and Drezek, R. "Integrated Imaging and Therapy of Cancer Using Immunotargeted Nanomaterials”, Expert Opinion on Drug Delivery." (2006).(In Revision)
Wang, H., Fu, K., Drezek R., and Halas, N "Light Scattering from Spherical Nanoantennas: Effects of Surface Roughness." Journal of Applied Physics B, 84 (2006): 191-196.
Hirsch, L., Lowery, A., Drezek, R., Halas, N, and West, J "Metal Nanoshells." Annals of Biomedical Engineering, 34 (2006): 15-22.
Boustany, N., Drezek, R., and Thakor, N. "Calcium-induced alterations in mitochondrial morphology quantified in situ with optical scattering imaging." Biophysical Journal, 83 (2002): 1691-1700.
Drezek, R., Sokolov, K., Malpica, A., Follen, M., and Richards-Kortum, R. "Understanding the Contributions of NADH and Collagen to Cervical Tissue Fluorescence Spectra: Modeling, Measurements, and Implications." Journal of Biomedical Optics, 6 (2001): 385-396.
Gobin, A., Lee, M., Drezek, R., and West, J "Nanoshells for Dual Imaging/Therapy: Results from an In Vivo Study." Nature Nanotechnology (2006).(Submitted)
Drezek, R., West, J., and Halas, N. "Optical Imaging for Minimally Invasive Medical Diagnosis." National Academy of Engineering Frontiers of Engineering (2006).
Book chapter
Chen, J., Lin, A., Loo, C., Hsu, K., West, J., Halas, N., and Drezek, R. "Optical Technologies for Noninvasive Functional and Molecular Imaging." Advanced Therapy of Breast Disease (2004): 859-868.
Loo, C., Lin, A., Hirsch, L., Lee, M., Barton, J., Halas, N., West, J., and Drezek, R. "Chapter 12: Diagnostic and Therapeutic Applications of Metal Nanoshells." In Nanofabrication for Biomedical Applications. (2005): 327-342.
West, J., Drezek, R., and Halas, N. "Chapter 25: Nanotechnology Provides New Tools for Biomedical Optics." Handbook of Biomedical Engineering (2005).(In Press)
Hirsch, L, Drezek, R., Halas, N, and West, J, "Diagnostic and Therapeutic Applications of Metal Nanoshells." In Encyclopedia of BioMEMs and Biomedical Nanotechnology, Volume III (2005): 147- 158.
Pavolova, I., Drezek, R., Chang, S., Arifler, D., Sokolov, K., Macaulay, C., Follen, M., and Richards-Kortum, R. "Fluorescence and Spectroscopic Markers of Cervical Neoplasia." Biomedical Imaging (2003).(In Press)
Drezek, R., West, J., and Halas, N. "Emerging Optical Technologies for Functional and Molecular Imaging." Advances in Diagnosis and Therapy of Breast Disease (2003).(In Press)
Richards-Kortum, R., Drezek, R., Pavlova, I., and Sokolov, K. "Chapter 8: Survey of Endogenous Biological Fluorophores." Fluorescence in Biomedicine (2003): 265-314.
Richards-Kortum, R., Drezek, R., Pavlova, I., and Sokolov, K. "Chapter 8: Survey of Endogeneous Biological Fluorophores." Fluorescence in Biomedicine (2003): 237-264.
Pavolova, I., Drezek, R., Chang, S., Arifler, D., Sokolov, K., Macaulay, C., Follen, M., and Richards-Kortum, R. "Fluorescence and Spectroscopic Markers of Cervical Neoplasia." Biomedical Imaging (2006).
West, J., Drezek, R., and Halas, N "Handbook of Biomedical Engineering." Nanotechnology Provides New Tools for Biomedical Optics, 18 (2006): 1-24.
Drezek, R., Zuluaga, A., and Richards-Kortum, R. "Chapter 16: Relationship Between Tissue Macroscopic Structure and Scattering Properties: Implications for OCT Imaging." Handbook of Optical Coherence Technology (2001): 445-470.
Conference paper
Pfefer, J. and Drezek, R. "Beveled Fiber Optic Probes for Biophotonics." Biophotonics West, 5317 (1/2004): 206-214.
Loo, C., Hirsch, L., Halas, N., West, J., and Drezek, R. "Biomedical Applications of Metal Nanoshells." Biophotonics West, 5327 (1/2004): 1-4.
Barton, J., West, J., Halas, N., and Drezek, R. "Nanoshells for Optical Coherence Tomography." Biophotonics West (1/2004).
Agrawal, A., Drezek, R., Pitris, C., Smithpeter, C., Utzinger, U., Brookner, C., Collier, T., Mitchell-Follen, M., and Richards-Kortum, R. "Acetic Acid: A Contrast Agent for Optical Imaging and Spectroscopy of Tissue." Biomedical Optical Spectroscopy and Diagnostics (1998): 39-41.
Richards-Kortum, R., Drezek, R., and Dunn, A. "Light-Scattering from Cells: Computations, Measurements, and Implications." Advances in Optical Imaging and Photon Migration Technical Digest (1998): 302.
Drezek, R., Kamath, A., MacAulay, C., and Richards-Kortum, R. "Light Scattering from Cells Throughout Neoplastic Progression: FDTD Modeling Based on Quantitative Cytology." OSA Biomedical 2000 Topical Meeting Technical Digest (2000): 325-327.
Boustany, N., Drezek, R., and Thakor, N. "Calcium-induced alterations in mitochondrial morphology quantified in situ with optical scattering imaging." OSA Biomedical 2002 Topical Meeting on Biomedical Optics Technical Digest (2002).
Drezek, R., Follen, M., and Richards-Kortum, R. "Optical Spectroscopy for the Detection of Cervical Precancers." IEEE International Conference on Biomedical Imaging (2002).
Drezek, R., Sokolov, K., and Richards-Kortum, R. "Understanding the Contributions of NADH and Collagen to Cervical Tissue Fluorescence Spectra: Modeling, Measurements, and Implications." Biophotonics West (2002).
Bickford, L., Chang, J., Fu, K., Sun, J., Hu, Y., Yu, T.K., Drezek R. "Immunotargeted Nanoshells for Potential Point of Care Diagnostic Applications." (March 2008).
Loo, C., Lowery, A., Hirsch, L., Halas, N., West, J., and Drezek, R. "Cancer Imaging Using Gold Nanoshells." OSA Biomedical Topical Meeting 2004 (4/2004).
Lin, A. and Drezek, R. "Wavelength Dependent Anisotropy of Gold Nanoshells." Proceedings of SPIE Optics East. (2005).
Pfefer, J., Agrawal, A., and Drezek, R. "Simulation of Oblique Incidence Probe Geometries for Fluorescence Spectroscopy." (2005).(In Press)
Pfefer, J., Agrawal, A., and Drezek, R. "Simulation of Oblique Incidence Probe Geometrics for Fluorescence Spectroscopy." OSA European Conference on Biomedical Optics (ECBO) (2005).
Agrawal, A., Huang, S., Pfefer, P., Lee, M., and Drezek R. "Quantitative Evaluation of Nanoshells as a Contrast Agents for OCT." (2005).(In Press)
Agrawal, A., Huang, S., Pfefer, P., Lee, M., and Drezek, R. "Quantitative Evaluation of Nanoshells as a Contrast Agent for 1300 nm OCT." Conference on Lasers and Electro-optics (CLEO) (2005).
Wang, A. and Drezek, R. "Oblique Angled Fiber Probes for Depth Sensitive Reflectance Measurements." Fiber Optics and Sensors V. Biophotonics West. (2005).(In Press)
Lin, A., Lowery, A., Hirsch, L., Halas, N., West, J., and Drezek, R. "Nanoshells for Cancer Imaging and Therapy." Optics East (2005).
O'Neal, P., Gobin, A., Bayazitoglu, Y., Halas, N., Drezek, R., and West, J. "Nanoshells as Exogenous Absorbers for Laser Tissue Welding." Photonics Therapeutics and Diagnostics (2005).(In Press)
Halas, N., Bishnoi, S., Jackson, J., Lin, R., and Drezek, R. "Nanoshell Based Raman Sensing of Biomaterials." Nano/biophotonics. (2005).(In Press)
Utzinger, U., Drezek, R., Kirkpatrick, N., and Brewer, M. "Endogenous Fluorescence of the Ovary." Optical Diagnostics and Sensing V. Biophotonics West. (2005).(In Press)
Appiah, B., Nammalvar, V., and Drezek, R. "Statistical analysis of FTIR spectra of cervical tissues and diagnostic algorithms for cervical cancer." Proceedings of SPIE, Vol. 6863, 68630V (February 2008).
Winkler, A., Rice, P., Troutman, T., Backer, J., Drezek, R. "Fluorescent and Scattering Contrast Agents in a Mouse Model of Colorectal Cancer." SPIE Proceedings, 6851 (January 20, 2008).
Utzinger, U., Drezek, R., Kirpatrick, N., and Brewer, M. "Endogenous Fluorescence of the Ovary. Optical Diagnostics and Sensing V.." (January 2005).(In Press)
O¿Neal, P., Gobin, A., Bayazitoglu, Y., Halas, N., Drezek, R., and West, J. "Nanoshells as an Exogenous Absorber for Laser Tissue Welding. Photonics Therapeutics and Diagnostics." (January 2005).(In Press)
Wang, A., and Drezek, R. "Oblique Angled Fiber Probes for Depth Sensitive Reflectance Measurements. Fiber Optics and Sensors V." (January 2005).(In Press)
Loo, C., Lowery, A., Hirsch, L., Halas, N., West, J., and Drezek, R. "Towards Molecular Imaging Using Gold Nanoshells." Biomaterials (2004).
Other
Lewinski, N., Colvin, V., and Drezek, R. "Cytoxicity of Nanomaterials." Small (2007).
Tuchin, V., Drezek, R., Nie, S., and Zharov, V. Guest Editorial: Nanophotonics for Diagnostics, Protection, and Treatment of Cancer and Inflammatory Diseases. Journal of Biomedical Optics(14), 020901. April (2009).
"Rice Lands $3M DOD Grant for Cancer Screening." Houston Business Journal. (2007).
"Review of Dynamic Optical Breast Imaging” Breast Diseases." (2006).
Chang, E., Miller, J. Sun, J. West, J*, and Drezek, R* "Quenched Quantum Dots as Protease Imaging Probes." (2006).
Lee, M., Nammalvar, V., Gobin, A., West, J., and Drezek, R "Nanoshells as Contrast Agents for Scatter-Based Optical Imaging." |
