Dipl.Ch.E. (1983) Aristotle University of Thessaloniki
M.S.Ch.E. (1985) Purdue University
Ph.D. (1988) Purdue University
Biomaterials, drug delivery, nanotechnology, gene therapy, tissue engineering
Email: mikos@rice.edu
Phone: (713)348-5355
Office: George R.Brown Hall, E100C
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Antonios Mikos
Louis Calder Professor of Bioengineering and Chemical Engineering
Our laboratory emphasizes the use of synthetic biodegradable polymers as supportive scaffolds for cells, as conduits for guided tissue growth, as specific substrates for targeted cell adhesion, or as stimulants for a desired cellular response. We are investigating bone regeneration and repair using a biodegradable polymer scaffold either by inducing bone tissue growth post-implantation or by seeding the scaffold with bone cells prior to implantation. We are developing new processing methods for manufacturing three-dimensional polymer scaffolds including combinations of solvent-casting or extrusion-molding with particulate-leaching techniques. We are further fabricating injectable, in situ polymerizable, biodegradable composite scaffolds for bone replacement also serving as carriers for bone cells and growth factors to induce a bone regeneration cascade. We are examining the effects of mechanical forces and flow on three-dimensional cultures of bone cells on the gene expression and the production of molecular mediators of mineralization and bone formation including extracellular matrix components and growth factors. We are also developing new CAD/CAM and polymer chemistry fabrication technologies for the production of synthetic biomimetic materials that exhibit the mechanical responsiveness and biochemical processing capabilities of living cells and tissues. We are synthesizing new injectable, in situ crosslinkable, biodegradable poly(ethylene glycol) copolyesters with covalently bound cell adhesion molecules for modulating cellular function to the hydrogel. We are designing new proactive hydrogels conducive to bone ingrowth but preclusive to fibrous infiltration for treating dental defects with guided tissue regeneration. Moreover, we are proposing the use of injectable biodegradable hydrogels after interventional cardiovascular procedures to repave and heal injured arteries and prevent arterial restenosis. We are fabricating thin films of biodegradable polymers with patterned surface chemistries and morphologies in an attempt to modulate the function of cultured cells with the ultimate goal of regenerating retinal pigment epithelium. We are manufacturing porous biodegradable polymer conduits for peripheral nerve regeneration to serve not only as guidance scaffolds but also as carriers for nerve growth factors and cells. Finally, we are developing non-viral gene delivery systems using synthetic polymers with targeting moieties for gene therapy.
Selected Publications
Abstract
A.M. Martins, A. Saraf, F.K. Kasper, C.M. Alves, R.L. Reis, and A.G. Mikos, Lipase Promotes Osteogenic Differentiation of Marrow Stromal Cells on SPCL Fiber Meshes under Flow Perfusion Conditions, Abstr. TERMIS-North America Ann. Confer. Exp., Abstract 420 (December 2008)
F.K. Kasper, R.A. Thibault, and A.G. Mikos, Mineralized Extracellular Matrix Constructs Support the Osteogenic Differentiation of Mesenchymal Stem Cells In Vitro, Abstr. AIChE Meeting, Abstract 579c (November 2008).
G. Cheng, H. Shin, A.G. Mikos, and K. Zygourakis "Expansion of Marrow Stromal Osteoblast Megacolonies on Biomimetic Hydrogels: Interpreting and Evaluating the Assay Data." Abstr. HSEMB Confer, Abstract 115 (2/2004).
X. Shi, J. Hudson, R.A. Horch, J.M. Tour, R. Krishnamoorti, and A.G. Mikos "Carbon Nanotube/Poly(Propylene Fumarate) Composites for Bone Tissue Engineering." Abstr. HSEMB Confer, Abstract 121 (2/2004).
F.K. Kasper, R.A. Thibault, and A.G. Mikos, Mineralized Extracellular Matrix Constructs for Bone Tissue Engineering, Abstr. Intern. Symp. Biomin., 10, Abstract F-01 (September 2008)
L. Klouda, M.C. Hacker, J.D. Kretlow, and A.G. Mikos, Synthesis and Characterization of Novel Thermoresponsive, Chemically Crosslinkable Macromers for the Fabrication of In Situ Forming Hydrogels, Abstr. HSEMB Confer., 25, Abstract 180 (February 2008).
A.G. Mikos, Synthetic Scaffolds for Tissue Engineering, Tissue Eng. Regen. Med., 5, Abstract IL-11 (June 2008).
A.G. Mikos, Synthetic Scaffolds for Tissue Engineering, Abstr. AIChE Meeting, Abstract 420d (November 2008).
P.Q. Ruhe, E.L. Hedberg, N.T. Padron, P.H.M. Spauwen, A.G. Mikos, and J.A. Jansen "Biocompatibility and Degradation of Injectable Poly(DL-Lactic-co-Glycolic Acid)/Calcium Phosphate Cement Composites." Abstr. IADR Meeting, Abstract 282 (3/2004).
H. Shin, G.C. Bowden, and A.G. Mikos "Osteogenic Differentiation of Marrow Stromal Cells Cultured on Biomimetic Hydrogels." Abstr. IADR Meeting, Abstract 910 (3/2004).
A.G. Mikos "Synthetic Polymers for Tissue Engineering." Abstr. ACS, 227, Abstract BMGT-2 (3/2004).
A.G. Mikos "Bioreactors for Bone Tissue Engineering." Abstr. Regenerate World Congr. Tissue Eng. Regen. Med., Abstract Orthopedic II-1 (April 2006).
B. Sitharaman, L.A. Tran, P.P. Spicer, I. Rusakova, A.G. Mikos, and L.J. Wilson "Fabrication and Characterization of Carbon Nanostructure In Situ Crosslinkable Composites for Bone Tissue Engineering." Abstr. Regenerate World Congr. Tissue Eng. Regen. Med., Abstract 254 (April 2006).
A.G. Mikos "Injectable Hydrogels for Stem Cell Delivery." Abstr. Intern. Collab. Symp. Stem Cell Res., 1, Abstract 49 (December 2006).
A.G. Mikos "Nanobiomaterials for Tissue Engineering." Intern. Conf. Biomed. Pharm. Eng., Abstract P-1 (December 2006).(Submitted)
A.S. Mistry, A.R. Barron, and A.G. Mikos "In Vitro Accelerated Degradation of a Poly(Propylene Fumarate)-Based/Alumoxane Nanocomposite for Bone Tissue Engineering." Abstr. HSEMB Confer. (February 2005): 22, Abstract 98.
M.C. Hacker and A.G. Mikos "Design of Injectable Biodegradable Polymers for Tissue Regeneration." Abstr. Sci. Confer. Soc. Phys. Regul. Biol. Med., 24, Abstract 57 (January 2006).
H. Park, T.A. Holland, J.S. Temenoff, and A.G. Mikos "Injectable Biodegradable Hydrogel Composites for Cell and Growth Factor Delivery for Cartilage Tissue Engineering." Abstr. Intern. Cartilage Repair Soc. Symp., 6, Abstract P3-2 (January 2006).
M.C. Hacker, B.B. Ma, and A.G. Mikos "Macromers for Injectable Cell Carriers for Tissue Engineering Applications." Abstr. Sci. Confer. Soc. Phys. Regul. Biol. Med., 24, Abstract 85 (January 2006).
A.G. Mikos "Musculoskel. Biol. Stem Cells Clin. Transl. Symp.." Delivery of DNA, Proteins, and Cells with Injectable Hydrogels (January 2007).
R.A. Horch, M.D. Timmer, A.R. Barron, and A.G. Mikos, "Reinforcement of Poly(Propylene Fumarate)-Based Networks with Surface Modified Alumoxane Nanoparticles for Bone Tissue Engineering." (2003): Abstract 138b.
B. Bucklen, M.A. Wettergreen, A.G. Mikos, and M.A. Liebschner, "Scaffold Design Using Model-Based Mechanotransduction Principles." (2003): Abstract 11.2.4.
T.A. Holland, J.K. Tessmar, Y. Tabata, and A.G. Mikos, "Sustained Release of Transforming Growth Factor-b1 from Novel Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels Encapsulating Gelatin Microparticles in Conditions that Model the Cartilage Wound Healing Environment." (2003): Abstract 6e.
A.G. Mikos, "Synthetic Polymers for Tissue Engineering." (2003): Abstract 368e.
J.P. Fisher, A.G. Mikos, and A.H. Reddi, "Hydrogel Scaffolds for Tissue Engineering of Articular Cartilage." (2003): Abstract 386b.
A.G. Mikos, "Fluid Flow in Tissue Engineering of 3D Bone Scaffolds." , 5 (2003): Abstract 14.
H.L. Holtorf, N. Datta, J.A. Jansen, and A.G. Mikos, "Effect of Scaffold Pore Size on Marrow Stromal Cell Differentiation in a Flow Perfusion Bioreactor." (2003): Abstract 2.P1.57.
E.L. Hedberg, C. Shih, L.A. Solchaga, A.I. Caplan, and A.G. Mikos, "Controlled Release of Hyaluronic Acid Oligomers from Biodegradable Polymeric Microparticles." (2003): Abstract 11.2.3.
V.I. Sikavitsas, G.N. Bancroft, H.L. Holtorf, J.A. Jansen, and A.G. Mikos, "Bone Tissue Engineering by Cell and In Vitro Generated Extracellular Matrix Transplantation." (2003): Abstract 2.P1.13.
V.I. Sikavitsas, G.N. Bancroft, J. van den Dolder, J.A. Jansen, and A.G. Mikos, "Bone Regeneration by Marrow Stromal Osteoblast Transplantation." (2003): Abstract 383d.
J.S. Temenoff, H. Park, E. Jabbari, and A.G. Mikos, "Bone Formation from Marrow Stromal Cells Encapsulated in Oligo(PEG Fumarate) Hydrogels." (2003): Abstract 2.6.2.
G. Cheng, H. Shin, A.G. Mikos, and K. Zygourakis, "3-Dimensional Transmigration of Human Dermal Fibroblasts from Collagen Gels to Biomimetic Hydrogels Modified with Peptide Sequences." (2003): Abstract 107cy.
L. Klouda, M.C. Hacker, L.H. Barg-Walkow, J.D. Kretlow, and A.G. Mikos, Cytocompatibility Evaluation of Novel Thermoresponsive and Chemically Crosslinkable Macromers for Injectable, In Situ Forming Hydrogels, Abstr. AIChE Meeting, Abstract 540a (November 2008).
H. Park, J.S. Temenoff, Y. Tabata, A.I. Caplan, R.M. Raphael, J.A. Jansen, and A.G. Mikos, Effect of Dual Growth Factor Delivery on Chondrogenic Differentiation of Rabbit Marrow Mesenchymal Stem Cells Encapsulated in Injectable Hydrogel Composites, Abstr. HSEMB Confer., 25, Abstract 199 (February 2008).
S.A. Chew, M.C. Hacker, A. Saraf, and A.G. Mikos, Effect of Hydrophilic Spacer Length on the Complexation of Novel Biodegradable Hyperbranched Polycationic Polymers and Plasmid DNA for Non-Viral Gene Delivery, Abstr. AIChE Meeting, Abstract 478g (November 2008).
X. Guo, H. Park, J.S. Temenoff, Y. Tabata, A.I. Caplan, and A.G. Mikos, Effect of Swelling Ratio of Injectable Hydrogel Composites on Chondrogenic Differentiation of Encapsulated Rabbit Marrow Mesenchymal Stem Cells In Vitro, Abstr. AIChE Meeting, Abstract 446d (November 2008)
K. Kim, M. Patel, D. Dean, A.G. Mikos, and J.P. Fisher, Endogenous Growth Factor Gene Expression Profile of Bone Marrow Stromal Cells on 3D Porous Poly(Propylene Fumarate)/Hydroxyapatite Nanocomposites, Abstr. AIChE Meeting, Abstract 463e (November 2008).
E. Burdett, A.G. Mikos, and J. Ludwig, Ewing’s Sarcoma Spheroids as a 3-D Model of In Vivo Biology Useful for High-Throughput Preclinical Screening of Antineoplastic Drug Candidates, Abstr. AIChE Meeting, Abstract 572bd (November 2008).
X. Guo, H. Park, and A.G. Mikos, In Vitro Osteogenic Differentiation of Rabbit Mesenchymal Stem Cells Encapsulated in Biodegradable Hydrogel Composites, Abstr. HSEMB Confer., 25, Abstract 200 (February 2008).
J.D. Kretlow, M.C. Hacker, L. Klouda, and A.G. Mikos, Injectable Calcium-Binding Macromers for Bone Tissue Engineering, Abstr. HSEMB Confer., 25, Abstract 181 (February 2008).
J.D. Kretlow, M.C. Hacker, B.B. Ma, L. Klouda, and A.G. Mikos, Injectable, In Situ Hardening Macromers for Bone Tissue Engineering, Abstr. AIChE Meeting, Abstract 499b (November 2008).
M.E. Gomes, C.M. Bossano, C.M. Johnston, R.L. Reis, and A.G. Mikos "Bone Growth Factors Expressed by Marrow Stromal Cells Cultured on Starch/Polycaprolactone Fiber Mesh Scaffolds under Flow Perfusion Conditions." Abstr. TESi/ETES Joint Meeting, Abstract 8 (10/2004).
H. Park, J.S. Temenoff, and A.G. Mikos "Injectable Biodegradable Hydrogels for TGF-b1 and Chondrocyte Delivery for Cartilage Tissue Engineering." Abstr. TESi/ETES Joint Meeting, Abstract 102 (10/2004).
M. Wettergreen, B. Bucklen, A.G. Mikos, and M.A.K. Liebschner "Tailoring the Mechanical Environment of Scaffolds with Computer Aided Design and Rapid Prototyping." Abstr. BMES Meeting, Abstract 295 (10/2004).
H. Castano, J.F. Alvarez-Barreto, J. Van den Dolder, J.A. Jansen, A.G. Mikos, and V.I. Sikavitsas "The Ability of Marrow Stromal Cells to Regenerate Bone Is Controlled by their Differentiation Stage." Abstr. BMES Meeting, Abstract 1044 (10/2004).
F.K. Kasper, Q.P. Pham, and A.G. Mikos "Generation of Tissue Engineering Scaffolds with a Flow Perfusion Bioreactor." Abstr. Intern. Bone Fluid Flow Workshop, 8, Abstract 30 (September 2007).
K. Kim, D. Dean, A.G. Mikos, and J.P. Fisher "Effect of Cell Seeding Density on Osteogenic Signaling of Bone Marrow Stromal Cells in 3D Scaffolds." (September 2007).
A.G. Mikos "Biomaterials in Tissue Engineering." (September 2007).
M.C. Hacker and A.G. Mikos "Novel Macromers for the Formation of Injectable, Calcium-Binding, In Situ Hardening Hydrogels." Abstr. BMES Meeting (September 2005): Abstract 92.
H.L. Holtorf, J.A. Jansen, and A.G. Mikos "Modulation of Cell Differentiation in Bone Tissue Engineering Constructs Cultured in a Flow Perfusion Bioreactor." Abstr. Intern. Bone Fluid Flow Workshop (September 2005): 7, Abstract 32.
S.A. Moore, J. Tessmar, and A.G. Mikos "Matrix Metalloproteinase-Sensitive Hydrogels for Articular Cartilage Engineering." Abstr. BMES Meeting (September 2005): Abstract 85.
Z.S. Patel, Y. Tabata, and A.G. Mikos "In Vitro Release of Vascular Endothelial Growth Factor from Gelatin Microparticles." Abstr. BMES Meeting (September 2005): Abstract 1066.
A.S. Mistry, A.R. Barron, A.G. Mikos, and J.A. Jansen "Degradation and Biocompatibility of a PPF-Based/Alumoxane Nanocomposite for Bone Tissue Engineering." Abstr. BMES Meeting (September 2005): Abstract 753.
M.C. Hacker, J.D. Kretlow, L. Klouda, B.B. Ma, and A.G. Mikos "Synthesis and Characterization of Novel Calcium-Binding Macromers for Injectable Tissue Engineering." Abstr. BMES Meeting, Abstract 935 (October 2006).
A. Haesslein, M.C. Hacker, H. Ueda, D.M. Ammon, R.N. Borazjani, J.F. Kunzler, J.C. Salamone, and A.G. Mikos "Long-Term Release of Glaucoma Therapeutics from Photo-Crosslinked Poly(Propylene Fumarate) Matrices." Abstr. BMES Meeting, Abstract 1504 (October 2006).
A.G. Mikos "Trends in Tissue Engineering Research: An Editor¿s Perspective." Abstr. TESi Meeting (October 2005): Abstract Spe-2.
H. Park, J.S. Temenoff, and A.G. Mikos "Injectable Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogel Composites for Concurrent Delivery of Marrow Stromal Cells and Growth Factors." Abstr. TESi Meeting (October 2005): Abstract 212.
A.G. Mikos "The Acad. Med. Eng. Sci. Texas Conf.." Biomaterials in Tissue Engineering (January 2007).
A.G. Mikos, T.A. Holland, F.K. Kasper, and J.S. Temenoff "Cell and Bioactive Factor Delivery from Injectable, Biodegradable Hydrogel Scaffolds for Tissue Engineering." Abstr. Intern. Confer. Mater. Adv. Technol. (July 2005): Abstract A-10-KN8.
A.G. Mikos "Nanobiomaterials for Tissue Engineering." Abstr. Biochem. Eng. Conf. & Symp. Nanomed. Tissue Eng., 11, Abstract 01-001 (June 2006).
E.M. Christenson, W. Soofi, J.L. Holmes, N.R. Cameron, and A.G. Mikos "Biodegradable PolyHIPEs as Tissue Engineering Scaffolds for Craniofacial Reconstruction." (March 2007).
W.J.E.M. Habraken, J.G.C. Wolke, A.G. Mikos, and J.A. Jansen "Calcium Phosphate/PLGA Microsphere Composites: Physical Properties and Degradation Characteristics." Aegean Confer. Ser. (May 2005): 16, Abstract 33.
H.L. Holtorf, J.A. Jansen, and A.G. Mikos "Modulation of Cell Differentiation in Bone Tissue Engineering Constructs Cultured in a Bioreactor." Aegean Confer. Ser. (May 2005): 16, Abstract 17.
U. Sharma, Q.P. Pham, N. Datta, and A.G. Mikos "Using Bone-like ECM Produced In Vitro to Influence Osteoblastic Differentiation of Marrow Stromal Cells." Abstr. AIChE Meeting (November 2005): Abstract 495e.
E. Christenson, W. Soofi, N. Cameron, and A.G. Mikos "Biodegradable Fumarate-Based PolyHIPEs as Tissue Engineering Scaffolds." Abstr. AIChE Meeting, Abstract 171b (November 2006).
N. Datta, Q.P. Pham, U. Sharma, V.I. Sikavitsas, J.A. Jansen, and A.G. Mikos "In Vitro Generated Extracellular Matrix and Fluid Shear Stress Synergistically Enhance 3D Osteoblastic Differentiation." Abstr. TESi Meeting (October 2005): Abstract 81.
A.S. Mistry, M. Hacker, A.R. Barron, and A.G. Mikos "Accelerated Degradation of a PPF-Based/Alumoxane Nanocomposite for Bone Tissue Engineering: Mechanical Properties and Macromolecular Structure." Abstr. TESi Meeting (October 2005): Abstract 62.
M.B. Murphy and A.G. Mikos "The Hydroxyapatite Affinity and Binding Kinetics of Peptides Modified with Bisphosphonates, Poly(Aspartic Acid), and Poly(Glutamic Acid)." Abstr. AIChE Meeting, Abstract 173f (November 2006).
A.G. Mikos "Delivery of DNA, Proteins, and Cells with Injectable Hydrogels." Abstr. AIChE Meeting, Abstract 155a (November 2006).
U. Sharma, Q. Pham, and A.G. Mikos "Flow Perfusion Culture of Marrow Stromal Cells on Electrospun Polycaprolactone Scaffolds." Abstr. AIChE Meeting, Abstract 680d (November 2006).
M.C. Hacker, L. Klouda, B.B. Ma, J.D. Kretlow, and A.G. Mikos "Novel Thermally Responsive Macromers for the Fabrication of Injectable, In Situ Crosslinkable Hydrogels." Abstr. AIChE Meeting, Abstract 190a (November 2006).
Article
H. Shin, K. Zygourakis, M.C. Farach-Carson, M.J. Yaszemski, and A.G. Mikos "Modulation of Differentiation and Mineralization of Marrow Stromal Cells Cultured on Biomimetic Hydrogels Modified with Arg-Gly-Asp Containing Peptides." J. Biomed. Mater. Res., Part A, 69A (2004): 535-543.
R.A. Horch, N. Shahid, A.S. Mistry, M.D. Timmer, A.G. Mikos, and A.R. Barron "Nanoreinforcement of Poly(Propylene Fumarate)-Based Networks with Surface Modified Alumoxane Nanoparticles for Bone Tissue Engineering." Biomacromolecules, 5 (2004): 1990-1998.
J. van den Dolder, G.N. Bancroft, V.I. Sikavitsas, P.H.M. Spauwen, J.A. Jansen, A. G. Mikos
"The Effect of Fibronectin and Collagen I Coated Titanium Fiber Mesh on Proliferation and Differentiation of Osteogenic Cells." Tissue Eng..(In Press)
Z. Lalani, M.E.K. Wong, E.M. Brey, A.G. Mikos, P.J. Duke, and C. Johnston "Spatial and Temporal Localization of Secretory IgA in Healing Tooth Extraction Sockets in a Rabbit Model." J. Oral Maxillofac. Surg, 62 (2004): 466-472.
Z. Lalani, M. Wong, E.M. Brey, C. Johnston, P.J. Duke, D. Montufar-Solis, A. G. Mikos "The Development of an Animal Model, Tissue Processing and Immunohistochemical Techniques for the Molecular Analysis of Wound Healing in a Tooth Extraction Socket." Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.(Submitted)
J.S. Temenoff, H. Park, E. Jabbari, D.E. Conway, T.L. Sheffield, C.G. Ambrose, and A.G. Mikos "Thermally-Crosslinked Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels Support Osteogenic Differentiation of Encapsulated Marrow Stromal Cells In Vitro." Biomacromolecules, 5 (2004): 5-10.
J.P. Fisher, S. Jo, A.G. Mikos, and A.H. Reddi "Thermoreversible Hydrogel Scaffolds for Articular Cartilage Engineering." J. Biomed. Mater. Res., Part A, 71A (2004): 268-274.
T.A. Holland, J.K.V. Tessmar, Y. Tabata, and A.G. Mikos "Transforming Growth Factor-b1 Release from Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels in Conditions Which Model the Cartilage Wound Healing Environment." J. Controlled Release, 94 (2004): 101-114.
E.L. Hedberg, H.C. Kroese-Deutman, C.K. Shih, J.J. Lemoine, M.A.K. Liebcshner, M.J. Miller, A.W. Yasko, R.S. Crowther, D.H. Carney, A.G. Mikos, and J.A. Jansen "A Comparative Analysis of Radiography, Microcomputed Tomography, and Histology for Bone Tissue Engineering." Tissue Eng., 11 (2005): 1356-1367.
P.Q. Ruh¿, E.L. Hedberg, N.T. Padron, P.H.M. Spauwen, J.A. Jansen, and A.G. Mikos "Biocompatibility and Degradation of Poly(DL-Lactic-co-Glycolic Acid)/Calcium Phosphate Cement Composites." J. Biomed. Mater. Res. Part A, 74A (2005): 533-544.
Z. Lalani, M. Wong, E.M. Brey, P.J. Duke, A. G. Mikos "Spatial and Temporal Localization of TGF-b1, BMP-2, and PDGF-A in Healing Tooth Extraction Sockets in a Rabbit Model." J. Oral Maxillofac. Surg.(In Press)
P.Q. Ruh¿, O.C. Boerman, F.G.M. Russel, P.H.M. Spauwen, A.G. Mikos, and J.A. Jansen "Controlled Release of rhBMP-2 Loaded Poly(DL-Lactic-co-Glycolic Acid)/Calcium Phosphate Cement Composites In Vivo." J. Controlled Release, 106 (2005): 162-171.
H. Park, J.S. Temenoff, T.A. Holland, Y. Tabata, and A.G. Mikos "Delivery of TGF-b1 and Chondrocytes via Injectable, Biodegradable Hydrogels for Cartilage Tissue Engineering Applications." Biomaterials, 26 (2005): 7095-7103.
T.A. Holland, Y. Tabata, and A.G. Mikos "Dual Growth Factor Delivery from Degradable Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogel Scaffolds for Cartilage Tissue Engineering." J. Controlled Release, 101 (2005): 111-125.
H.L. Holtorf, J.A. Jansen, and A.G. Mikos "Ectopic Bone Formation in Rat Marrow Stromal Cell/Titanium Fiber Mesh Scaffold Constructs: Effect of Initial Cell Phenotype." Biomaterials, 26 (2005): 6208-6216.
N. Datta, H.L. Holtorf, V.I. Sikavitsas, J.A. Jansen, and A.G. Mikos "Effect of Bone Extracellular Matrix Synthesized In Vitro on the Osteoblastic Differentiation of Marrow Stromal Cells." Biomaterials, 26 (2005): 971-977.
D. Dean, M.S. Wolfe, Y. Ahmad, A. Totonchi, J.E.-K. Chen, J.P. Fisher, M.N. Cooke, C.M. Rimnac, D.P. Lennon, A.I. Caplan, N.S. Topham, and A.G. Mikos "Effect of Transforming Growth Factor b2 on Marrow-Infused Foam Poly(Propylene Fumarate) Tissue-Engineered Constructs for the Repair of Critical-Size Cranial Defects in Rabbits." Tissue Eng., 11 (2005): 923-939.
E. Cosgriff-Hernandez and A.G. Mikos, New Biomaterials as Scaffolds for Tissue Engineering, Pharm. Res., 25, 2345-2347 (2008)
Z. Lalani, M. Wong, E.M. Brey, A.G. Mikos, and P.J. Duke, "Spatial and Temporal Localization of Transforming Growth Factor-b1, Bone Morphogenetic Protein-2, and Platelet-Derived Growth Factor-A in Healing Tooth Extraction Sockets in a Rabbit Model." J. Oral Maxillofac. Surg., 61 (2003): 1061-1072.
H.L. Holtorf, N. Datta, J.A. Jansen, and A.G. Mikos "Scaffold Mesh Size Affects the Osteoblastic Differentiation of Seeded Marrow Stromal Cells Cultured in a Flow Perfusion Bioreactor." J. Biomed. Mater. Res. Part A, 74A (205): 171-180.
J.P. Fisher, A.G. Mikos, and P.C. Johnson, Tomorrows Tissue Engineering Triumphs Require Understanding of Todays Achievements, Tissue Eng. Part B: Reviews, 14, 1 (2008).
Z. Lalani, M. Wong, E.M. Brey, C. Johnston, A.G. Mikos, P.J. Duke, and D. Montufar-Solis, "The Development of an Animal Model, Tissue Processing and Immunohistochemical Techniques for the Molecular Analysis of Wound Healing in a Tooth Extraction Socket." J. Histochem. Cytochem. (2003).(Submitted)
J.K. Tessmar, A.G. Mikos, and A. Goepferich, "The Use of Poly(Ethylene Glycol)-block-Poly(Lactic Acid) Derived Copolymers for the Rapid Creation of Biomimetic Surfaces." Biomaterials, 24 (2003): 4475-4486.
E. Behravesh and A.G. Mikos, "Three-Dimensional Culture of Differentiating Marrow Stromal Osteoblasts in Biomimetic Poly(Propylene Fumarate-co-Ethylene Glycol)-Based Macroporous Hydrogels." J. Biomed. Mater. Res. Part A, 66A (2003): 698-706.
M.N. Cooke, J.P. Fisher, D. Dean, C. Rimnac, and A.G. Mikos, "Use of Stereoliphography to Manufacture Critical-Sized 3D Biodegradable Scaffolds for Bone Ingrowth." J. Biomed. Mater. Res. Part B: Appl. Biomater.,, 64B (2003): 65-69.
P.Q. Ruhe, E.L. Hedberg, N.T. Padron, P.H.M. Spauwen, J.A. Jansen, and A.G. Mikos, "rhBMP-2 Release from Injectable Poly(DL-Lactic-co-Glycolic Acid)/Calcium Phosphate Cement Composites." J. Bone Joint Surg, 85-A, Suppl. 3 (2003): 75-81.
Z.S. Patel and A.G. Mikos "Angiogenesis with Biomaterial-Based Drug- and Cell-Delivery Systems." J. Biomater. Sci., Polym, Ed. 15 (2004): 701-726.
H. Shin, K. Zygourakis, M.C. Farach-Carson, M.J. Yaszemski, and A.G. Mikos "Attachment, Proliferation, and Migration of Marrow Stromal Osteoblasts Cultured on Biomimetic Hydrogels Modified with an Osteopontin-Derived Peptide." Biomaterials, 25 (2004): 895-906.
E.L. Hedberg, C.K. Shih, L.A. Solchaga, A.I. Caplan, and A.G. Mikos "Controlled Release of Hyaluronan Oligomers from Biodegradable Polymeric Microparticle Carriers." J. Controlled Release, 100 (2004): 257-266.
J.S. Blum, J.S. Temenoff, H. Park, J.A. Jansen, A.G. Mikos, and M.A. Barry "Development and Characterization of Enhanced Green Fluorescent Protein and Luciferase Expressing Cell Line for Non-Destructive Evaluation of Tissue Engineering Constructs." Biomaterials, 25 (2004): 5809-5819.
J.S. Blum, M.B. Parrott, A.G. Mikos, and M.A. Barry "Early Osteoblastic Differentiation Induced by Dexamethasone Enhances Adenoviral Gene Delivery to Marrow Stromal Cells." J. Orthop. Res., 22 (2004): 411-416.
J.P. Fisher, Z. Lalani, C.M. Bossano, E.M. Brey, N. Demian, C.M. Johnston, D. Dean, J.A. Jansen, M.E.K. Wong, and A.G. Mikos "Effect of Biomaterial Properties on Bone Healing in a Rabbit Tooth Extraction Socket Model." J. Biomed. Mater. Res., Part A, 68A (2004): 428-438.
C.G. Ambrose, T.A. Clyburn, K. Louden, J. Joseph, J. Wright, P. Gulati, G.R. Gogola, and A.G. Mikos "Effective Treatment of Osteomyelitis with Biodegradable Microspheres in a Rabbit Model." Clin. Orthop. Rel. Res (2004): 421, 293-299.
J.S. Temenoff, H. Park, E. Jabbari, T.L. Sheffield, R.G. LeBaron, C.G. Ambrose, and A.G. Mikos "In Vitro Osteogenic Differentiation of Marrow Stromal Cells Encapsulated in Biodegradable Hydrogels." J. Biomed. Mater. Res, Part A, 70A (2004): 235-244.
G.N. Bancroft, V.I. Sikavitsas, A. G. Mikos "Design of a Flow Perfusion Bioreactor System for Bone Tissue Engineering Applications." Tissue Eng..(In Press)
T.A. Holland, E.W.H. Bodde, L.S. Baggett, Y. Tabata, A.G. Mikos, and J.A. Jansen "Osteochondral Repair in the Rabbit Model Utilizing Bilayered, Degradable Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogel Scaffolds." J. Biomed. Mater. Res. Part A, 75A (2005): 156-167.
H. Shin, J.S. Temenoff, G.C. Bowden, K. Zygourakis, M.C. Farach-Carson, M.J. Yaszemski, and A.G. Mikos "Osteogenic Differentiation of Rat Bone Marrow Stromal Cells Cultured on Arg-Gly-Asp Modified Hydrogels without Dexamethasone and b-Glycerol Phosphate." Biomaterials, 26 (2005): 3645-3654.
P.Q. Ruh¿, E.L. Hedberg, N.T. Padron, P.H.M. Spauwen, J.A. Jansen, and A.G. Mikos "Porous poly(DL-Lactic-co-Glycolic Acid)/Calcium Phosphate Cement Composite for Reconstruction of Bone Defects." Tissue Eng. (2005).(In Press)
L.A. Solchaga, J.S. Temenoff, J. Gao, A.G. Mikos, A.I. Caplan, and V.M. Goldberg "Repair of Osteochondral Defects with Hyaluronan- and Polyester-Based Scaffolds." Osteoarthritis Cartilage, 13 (2005): 297-309.
X. Shi, J.L. Hudson, P.P. Spicer, J.M. Tour, R. Krishnamoorti, and A.G. Mikos "Rheological Behavior and Mechanical Characterization of Injectable Poly(Propylene Fumarate)/Single-Walled Carbon Nanotube Composites for Bone Tissue Engineering." Nanotechnology, 16 (2005): S531-S538.
Z. Lalani, M. Wong, E.M. Brey, A.G. Mikos, P.J. Duke, M.J. Miller, C. Johnston, and D. Montufar-Solis "Spatial and Temporal Localization of FGF-2 and VEGF in Healing Tooth Extraction Sockets in a Rabbit Model." J. Oral Maxillofac. Surg., 63 (2005): 1500-1508.
A.S. Mistry and A.G. Mikos "Tissue Engineering Strategies for Bone Regeneration." Adv. Biochem. Eng. Biotechnol., 94 (2005): 1-22.
A.G. Mikos and P.C. Johnson "Editorial: Redefining Tissue Engineering... and Our New Rapid Publication Policy." Tissue Eng, 12 (2006): 1379-1380.
W.T. Godbey and A.G. Mikos "Gene Delivery for Tissue Engineering." Adv. Drug Deliv. Rev.,, 58 (2006): 465-466.
J.P. Fisher and A.G. Mikos "Section V: Tissue Engineering in Tissue Engineering and Artificial Organs." The Biomedical Engineering Handbook, Vol. 3, 3rd Ed., J.D. Bronzino, Ed (2006): V–1-V–4.
A. Domb and A.G. Mikos "Matrices and Scaffolds for Drug Delivery in Tissue Engineering." Adv. Drug Deliv. Rev., 59 (2007): 185-186.
F. Bronner, M.C. Farach-Carson, and A.G. Mikos "Preface, in Engineering of Functional Skeletal Tissues." Topics in Bone Biology, 3 (2007): v-viii.
J.P. Fisher, A.G. Mikos, P.C. Johnson, and J.A. Jansen, A Continued Commitment to Quality Research in Tissue Engineering, Tissue Eng. Part A, 14, 1457-1458 (2008).
J.A. Jansen, A.G. Mikos, and P.C. Johnson, A New Focus on the Methods of Tissue Engineering, Tissue Eng. Part C: Methods, 14, 1 (2008).
J.K. Tessmar, A. Goepferich, A. G. Mikos "Biomimetic Derivatives of Poly(Ethylene Glycol)-block-Poly(Lactic Acid) Copolymers for Instant Type Surface Modifications." Biomaterials.(In Press)
C.G. Ambrose, T.A. Clyburn, K. Louden, J. Joseph, J. Wright, P. Gulati, G.R. Gogola, A. G. Mikos "Antibiotic Microspheres for Osteomyelitis Treatment: Part 2 - In-Vivo Treatment of Infections." Clin. Orthop. Rel. Res.(Submitted)
C.G. Ambrose, G.R. Gogola, T.A. Clyburn, A.K. Raymond, A.S. Peng, A. G. Mikos "Antibiotic Microspheres for Osteomyelitis Treatment: Part 1 - Preliminary Testing." Clin. Orthop. Rel. Res..(Submitted)
E.L. Hedberg, H.C. Kroese-Deutman, C.K. Shih, R.S. Crowther, D.H. Carney, A.G. Mikos, and J.A. Jansen "Effect of Varied Release Kinetics of the Osteogenic Thrombin Peptide TP508 from Biodegradable, Polymeric Scaffolds on Bone Formation In Vivo." J. Biomed. Mater. Res. Part A, 72A (2005): 343-353.
Q. Pham, U. Sharma, and A.G. Mikos "Electrospinning of Polymeric Nanofibers for Tissue Engineering Applications." Tissue Eng. (2005).(In Press)
H.L. Holtorf, J.A. Jansen, and A.G. Mikos "Flow Perfusion Culture Induces the Osteoblastic Differentiation of Marrow Stromal Cell-Scaffold Constructs in the Absence of Dexamethasone." J. Biomed. Mater. Res. Part A, 72A (2005): 326-334.
E. Behravesh, V.I. Sikavitsas, and A.G. Mikos, "Quantification of Ligand Surface Concentration of Bulk-Modified Biomimetic Hydrogels." Biomaterials, 24: 4365-4374.
H.L. Holtorf, T.L. Sheffield, C.G. Ambrose, J.A. Jansen, and A.G. Mikos "Flow Perfusion Culture of Marrow Stromal Cells Seeded on Porous Biphasic Calcium Phosphate Ceramics." Ann. Biomed. Eng., 33 (2005): 1238-1248.
D. Dean, N.S. Topham, S.C. Meneghetti, M.S. Wolfe, K. Jepsen, S. He, J.E.-K. Chen, J.P. Fisher, M.N. Cooke, C. Rimnac, A. G. Mikos "Poly(Propylene Fumarate) and Poly(DL-Lactic-co-Glycolic Acid) as Scaffold Materials for Solid and Foam-Coated Composite Tissue Engineered Constructs for Cranial Reconstruction." Tissue Eng..(In Press)
V.I. Sikavitsas, G.N. Bancroft, J.J. Lemoine, M.A.K. Liebschner, M. Dauner, and A.G. Mikos "Flow Perfusion Enhances the Calcified Matrix Deposition of Marrow Stromal Cells in Biodegradable Nonwoven Fiber Mesh Scaffolds." Ann. Biomed. Eng., 33 (2005): 63-70.
E. Behravesh, M.D. Timmer, J.J. Lemoine, M.A.K. Liebschner, A. G. Mikos "Evaluation of the In Vitro Degradation of Macroporous Hydrogels Using Gravimetry, Confined Compression Testing, and Microcomputed Tomography." Biomacromolecules.(In Press)
M.E. Gomes, V.I. Sikavitsas, E. Behravesh, R.L. Reis, A. G. Mikos "Effect of Flow Perfusion on the Osteogenic Differentiation of Bone Marrow Stromal Cells Cultured on Starch-Based Three-Dimensional Scaffolds." J. Biomed. Mater. Res..(Submitted)
C.-Y. Lin, R.M. Schek, A.S. Mistry, X. Shi, A.G. Mikos, P.H. Krebsbach, and S.J. Hollister "Functional Bone Engineering Using Ex Vivo Gene Therapy and Topology-Optimized, Biodegradable Polymer Composite Scaffolds." Tissue Eng., 11 (2005): 1589-1598.
S. Young, M. Wong, Y. Tabata, and A.G. Mikos "Gelatin as a Delivery Vehicle for the Controlled Release of Bioactive Molecules." J. Controlled Release, 109 (2005): 256-274.
J.A. Jansen, J.W.M. Vehof, P.Q. Ruh¿, H. Kroeze-Deutman, Y. Kuboki, H. Takita, E.L. Hedberg, and A.G. Mikos "Growth Factor-Loaded Scaffolds for Bone Engineering." J. Controlled Release, 101 (2005): 127-136.
E.L. Hedberg, C.K. Shih, J.J. Lemoine, M.D. Timmer, M.A.K. Liebschner, J.A. Jansen, and A.G. Mikos "In Vitro Degradation of Porous Poly(Propylene Fumarate)/Poly(DL-Lactic-co-Glycolic Acid) Composite Scaffolds." Biomaterials, 26 (2005): 3215-3225.
F.K. Kasper, S.K. Seidlits, A. Tang, R.S. Crowther, D.H. Carney, M.A. Barry, and A.G. Mikos "In Vitro Release of Plasmid DNA from Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels." J. Controlled Release, 104 (2005): 521-539.
E.L. Hedberg, H.C. Kroese-Deutman, C.K. Shih, R.S. Crowther, D.H. Carney, A.G. Mikos, and J.A. Jansen "In Vivo Degradation of Porous Poly(Propylene Fumarate)/Poly(DL-Lactic-co-Glycolic Acid) Composite Scaffolds." Biomaterials, 26 (2005): 4616-4623.
F.K. Kasper, T. Kushibiki, Y. Kimura, A.G. Mikos, and Y. Tabata "In Vivo Release of Plasmid DNA from Composites of Oligo(Poly(Ethylene Glycol) Fumarate) and Cationized Gelatin Microspheres." J. Controlled Release, 107 (2005): 547-561.
P.Q. Ruh¿, O.C. Boerman, F.G.M. Russel, A.G. Mikos, P.H.M. Spauwen, and J.A. Jansen "In Vivo Release of rhBMP-2 Loaded Porous Calcium Phosphate Cement Pretreated with Albumin." Biomaterials (2005).(Submitted)
H.L. Holtorf, J.A. Jansen, and A.G. Mikos "Modulation of Cell Differentiation in Bone Tissue Engineering Constructs Cultured in a Bioreactor." Adv. Exp. Med. Biol. (2005).(In Press)
J.S. Temenoff, K.A. Athanasiou, R.G. LeBaron, A. G. Mikos "Effect of Poly(Ethylene Glycol) Molecular Weight on Tensile and Swelling Properties of Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels for Cartilage Tissue Engineering." J. Biomed. Mater. Res, 59 (2002): 429-437.
J.S. Temenoff, H. Shin, D.E. Conway, P.S. Engel, and A.G. Mikos, "In Vitro Cytotoxicity of Redox Radical Initiators for Crosslinking of Oligo(Poly(Ethylene Glycol) Fumarate) Macromers." Biomacromolecules, 4 (2003): 1605-1613.
M.D. Timmer, H. Shin, R.A. Horch, C.G. Ambrose, and A.G. Mikos, "In Vitro Cytotoxicity of Injectable and Biodegradable Poly(Propylene Fumarate)-Based Networks: Unreacted Macromers, Cross-Linked Networks, and Degradation Products." Biomacromolecule, 4 (2003): 1026-1033.
G.N. Bancroft, V.I. Sikavitsas, J. van den Dolder, T.L. Sheffield, C.G. Ambrose, J.A. Jansen, A. G. Mikos "Fluid Flow Increases Mineralized Matrix Deposition in 3D Perfusion Culture of Marrow Stromal Osteoblasts in a Dose-Dependent Manner." Proceed. Natl. Acad. Sci. USA, 99 (2002): 12600-12605.
J. van den Dolder, G.N. Bancroft, V.I. Sikavitsas, P.H.M. Spauwen, J.A. Jansen, and A.G. Mikos, "Flow Perfusion Culture of Marrow Stromal Osteoblasts in Titanium Fiber Mesh." J. Biomed. Mater. Res. Part A,, 64A (2003): 235-241.
M.D. Timmer, C. Carter, C.G. Ambrose, and A.G. Mikos "Fabrication of Poly(Propylene Fumarate)-Based Orthopaedic Implants by Photo-Crosslinking Through Transparent Silicone Molds." Biomaterials, 24 (2003): 4707-4714.
M.D. Timmer, C.G. Ambrose, and A.G. Mikos, "Evaluation of Thermal- and Photo-Crosslinked Biodegradable Poly(Propylene Fumarate)-Based Networks." J. Biomed. Mater. Res. Part A, 66A (2003): 811-818.
C.G. Ambrose, T.A. Clyburn, K. Louden, J. Joseph, J. Wright, P. Gulati, G.R. Gogola, and A.G. Mikos, "Efficacy of Biodegradable Tobramycin Microspheres in a Rabbit Osteomyelitis Model." Clin. Orthop. Rel. Res. (2003).(In Press)
V.I. Sikavitsas, G.N. Bancroft, A. G. Mikos "Formation of Three-Dimensional Cell/Polymer Constructs for Bone Tissue Engineering in a Spinner Flask and a Rotating Wall Vessel Bioreactor." J. Biomed. Mater. Res., 62 (2002): 136-148.
J.S. Temenoff, H. Park, E. Jabbari, T.L. Sheffield, R.G. LeBaron, C.G. Ambrose, and A.G. Mikos, "Effect of Swelling Properties of Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels and Addition of Media Supplements on In-Vitro Osteogenic Differentiation of Encapsulated Marrow Stromal Cells." J. Biomed. Mater. Res. Part A (2003).(Submitted)
M.D. Timmer, R.A. Horch, C.G. Ambrose, and A.G. Mikos, "Effect of Physiological Temperature on the Mechanical Properties and Network Structure of Biodegradable Poly(Propylene Fumarate)-Based Networks." J. Biomater. Sci., Polym. Ed, 14 (2003): 369-382.
K. Tanahashi and A.G. Mikos, "Effect of Hydrophilicity and Agmatine Modification on Degradation of Poly(Propylene Fumarate-co-Ethylene Glycol) Hydrogels." J. Biomed. Mater. Res. Part A, 67A (2003): 1148-1154.
J. van den Dolder, G.N. Bancroft, V.I. Sikavitsas, P.H.M. Spauwen, A.G. Mikos, and J.A. Jansen "Effect of Fibronectin- and Collagen I-Coated Titanium Fiber Mesh on Proliferation and Differentiation of Osteogenic Cells." Tissue Engr, 9 (2003): 505-515.
J.S. Temenoff, E.S. Steinbis, and A.G. Mikos, "Effect of Drying History on Swelling Properties and Cell Attachment to Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels for Guided Tissue Regeneration Applications." J. Biomater. Sci., Polym. Ed., 14 (2003): 989-1004.
G.N. Bancroft, V.I. Sikavitsas, and A.G. Mikos, "Design of a Flow Perfusion Bioreactor System for Bone Tissue-Engineering Applications." Tissue Eng, 9 (2003): 549-554.
A.K. Shung, E. Behravesh, S. Jo, and A.G. Mikos, "Crosslinking Characteristics of and Cell Adhesion to an Injectable Poly(Propylene Fumarate-co-Ethylene Glycol) Hydrogel Using a Water Soluble Crosslinking System." Tissue Eng, 9 (2003): 243-254.
M.S. Wolfe, D. Dean, J.E. Chen, J.P. Fisher, S. Han, C.M. Rimnac, A. G. Mikos
"In Vitro Degradation and Fracture Toughness of Multilayered Porous Poly(Propylene Fumarate)/b-Tricalcium Phosphate Scaffolds." J. Biomed. Mater. Res, 61 (2002): 159-164.
J.S. Blum, M.A. Barry, and A.G. Mikos, "Bone Regeneration through Transplantation of Genetically Modified Cells." Clin. Plast. Surg., 30 (2003): 611-620.
A.K. Shung, M.D. Timmer, S. Jo, P.S. Engel, A. G. Mikos "Kinetics of Poly(Propylene Fumarate) Synthesis by Step Polymerization of Diethyl Fumarate and Propylene Glycol Using Zinc Chloride as a Catalyst." J. Biomater. Sci., Polym. Ed., 13 (2002): 95-108.
H. Shin, S. Jo, and A.G. Mikos, "Biomimetic Materials for Tissue Engineering." Biomaterials, 24 (2003): 4353-4364.
A. G. Mikos, H. Shin, S. Jo "Modulation of Marrow Stromal Osteoblast Adhesion on Biomimetic Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels Modified with Arg-Gly-Asp Peptides and a Poly(Ethylene Glycol) Spacer." J. Biomed. Mater. Res, 61 (2002): 169-179.
J.P. Fisher, D. Dean, A. G. Mikos "Photocrosslinking Characteristics and Mechanical Properties of Diethyl Fumarate/Poly(Propylene Fumarate) Biomaterials." Biomaterials, 23 (2002): 4333-4343.
J.P. Fisher, J.W.M. Vehof, D. Dean, J.P.C.M. van der Waerden, T.A. Holland, A. G. Mikos
"Soft and Hard Tissue Response to Photocrosslinked Poly(Propylene Fumarate) Scaffolds in a Rabbit Model." J. Biomed. Mater. Res, 59 (2002): 547-556.
K. Tanahashi, S. Jo, A. G. Mikos "Synthesis and Characterization of Biodegradable Cationic Poly(Propylene Fumarate-co-Ethylene Glycol) Copolymer Hydrogels Modified with Agmatine for Enhanced Cell Adhesion." Biomacromolecules, 3 (2002): 1030-1037.
C.G. Ambrose, G.R. Gogola, T.A. Clyburn, A.K. Raymond, A.S. Peng, and A.G. Mikos, "Antibiotic Microspheres: Preliminary Testing for Potential Treatment of Osteomyelitis." Clin. Orthop. Rel. Res., 415 (2003): 279-285.
Z.S. Patel and A.G. Mikos, "Angiogenesis with Biomaterial-Based Drug and Cell Delivery Systems." J. Biomater. Sci., Polym. Ed. (2003).(Submitted)
E. Behravesh, A.K. Shung, S. Jo, A. G. Mikos "Synthesis and Characterization of Triblock Copolymers of Methoxy Poly(Ethylene Glycol) and Poly(Propylene Fumarate)." Biomacromolecules, 3 (2002): 153-158.
T.A. Holland and A.G. Mikos, "Advances in Drug Delivery for Articular Cartilage." J. Controlled Release, 86 (2003): 1-14.
E. Behravesh, K. Zygourakis, and A.G. Mikos, "Adhesion and Migration of Marrow-Derived Osteoblasts on Injectable In Situ Crosslinkable Poly(Propylene Fumarate-Co-Ethylene Glycol) Based Hydrogels with a Covalently Linked RGDS Peptide." J. Biomed. Mater. Res. Part A, 65A (2003): 261-271.
E. Behravesh, S. Jo, K. Zygourakis, A. G. Mikos
"Synthesis of In Situ Crosslinkable Macroporous Biodegradable Poly(Propylene Fumarate-co-Ethylene Glycol) Hydrogels." Biomacromolecules, 3 (2002): 374-381.
H. Shin, P.Q. Ruhe, A.G. Mikos, and J.A. Jansen, "In Vivo Bone and Soft Tissue Response to Injectable Biodegradable Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels." Biomaterials, 24 (2003): 3201-3211.
J.S. Blum, M.A. Barry, A.G. Mikos, and J.A. Jansen "In Vivo Evaluation of Gene Therapy Vectors in Ex Vivo Derived Marrow Stromal Cells for Bone Regeneration in a Rat Critical Size Calvarial Defect Model." Human Gene Therapy (2003).(In Press)
M.D. Timmer, S. Jo, C. Wang, C.G. Ambrose, A. G. Mikos "Characterization of the Cross-Linked Structure of Fumarate-Based Degradable Polymer Networks." Macromolecules, 35 (2002): 4373-4379.
K. Tanahashi, A. G. Mikos "Cell Adhesion on Poly(Propylene Fumarate-co-Ethylene Glycol) Hydrogels." J. Biomed. Mater. Res., 62 (2002): 558-566.
A. G. Mikos "Cationic and Non-Condensing Polymer-Based Gene Delivery." Pharmaceutical Perspectives of Nucleic Acid-Based Therapeutics (2002): 367-387.
J.W.M. Vehof, J.P. Fisher, D. Dean, J.-P.C.M. van der Waerden, P.H.M. Spauwen, J.A. Jansen, A. G. Mikos "Bone Formation in Transforming Growth Factor b-1-Coated Porous Poly(Propylene Fumarate) Scaffolds." J. Biomed. Mater. Res, 60 (2002): 241-251.
V.I. Sikavitsas, J. van den Dolder, G.N. Bancroft, P.H.M. Spauwen, J.A. Jansen, and A.G. Mikos, "Influence of the In Vitro Culture Period on the In Vivo Performance of Cell/Titanium Bone Tissue Engineered Constructs Using a Rat Cranial Critical Size Defect Model." J. Biomed. Mater. Res. Part A, 67A (2003): 944-951.
V.I. Sikavitsas, G.N. Bancroft, H.L. Holtorf, J.A. Jansen, and A.G. Mikos, "Mineralized Matrix Deposition by Marrow Stromal Osteoblasts in 3D Perfusion Culture Increases with Increasing Fluid Shear Forces." Proceed. Natl. Acad. Sci. USA, 100 (2003): 14683-14688.
E.L. Chaikof, H. Matthew, J. Kohn, G.D. Prestwich, C.M. Yip, A. G. Mikos "Bioscaffolds for Tissue Repair." Ann. N.Y. Acad. Sci., 961 (2002): 112-113.
H. Shin, K. Zygourakis, M.C. Farach-Carson, M.J. Yaszemski, and A.G. Mikos, "Modulation of Differentiation and Mineralization of Marrow Stromal Cells Cultured on Biomimetic Hydrogels Modified with an Osteopontin-Derived Peptide." J. Biomed. Mater. Res. Part A (2003).(Submitted)
J.P. Fisher, M.D. Timmer, T.A. Holland, D. Dean, P.S. Engel, and A.G. Mikos, "Photoinitiated Cross-Linking of the Biodegradable Polyester Poly(Propylene Fumarate). Part I: Determination of Network Structure." Biomacromolecules, 4 (2003): 1327-1334.
J.P. Fisher, T.A. Holland, D. Dean, and A.G. Mikos, "Photoinitiated Crosslinking of the Biodegradable Polyester Poly(Propylene Fumarate). Part II: In Vitro Degradation." Biomacromolecules, 4 (2003): 1335-1342.
E.L. Chaikof, H. Matthew, J. Kohn, A. G. Mikos "Biomaterials and Scaffolds in Reparative Medicine." Ann. N.Y. Acad. Sci., 961 (2002): 96-105.
E. Lieb, J. Tessmar, M. Hacker, C. Fischbach, D. Rose, T. Blunk, A.G. Mikos, A. G¿pferich, and M.B. Schulz, "Poly(D,L-Lactic Acid)-Poly(Ethylene Glycol)-Monomethyl Ether Diblock Copolymers Control Adhesion and Osteoblastic Differentiation of Marrow Stromal Cells." Tissue Engr., 9 (2003): 71-84.
D. Dean, N.S. Topham, S.C. Meneghetti, M.S. Wolfe, K. Jepsen, S. He, J.E.-K. Chen, J.P. Fisher, M. Cooke, C. Rimnac, and A.G. Mikos, "Poly(Propylene Fumarate) and Poly(DL-Lactic-co-Glycolic Acid) as Scaffold Materials for Solid and Foam-Coated Composite Tissue-Engineered Constructs for Cranial Reconstruction." Tissue Engr, 9 (2003): 495-504.
K. Tanahashi and A.G. Mikos, "Protein Adsorption and Smooth Muscle Cell Adhesion on Biodegradable Agmatine-Modified Poly(Propylene Fumarate-co-Ethylene Glycol) Hydrogels." J. Biomed. Mater. Res. Part A, 67A (2003): 448-457.
G.R.D. Evans, K. Brandt, S. Katz, P. Chauvin, L. Otto, M. Bogle, B. Wang, R.K. Meszlenyi, L. Lu, C.W. Patrick, Jr., A. G. Mikos "Bioactive Poly(L-Lactic Acid) Conduits Seeded with Schwann Cells for Peripheral Nerve Regeneration." Biomaterials, 23 (2002): 841-848.
J.K. Tessmar, A. Goepferich, A. G. Mikos "Amine-Reactive Biodegradable Diblock Copolymers." Biomacromolecules, 3 (2002): 194-200.
H. Shin, J.S. Temenoff, and A.G. Mikos "In Vitro Cytotoxicity of Unsaturated Oligo(Poly(Ethylene Glycol) Fumarate) Macromers and their Crosslinked Hydrogels." Biomacromolecule, 4 (2003): 552-560.
T.A. Holland, Y. Tabata, and A.G. Mikos, "In Vitro Release of Transforming Growth Factor-b1 from Gelatin Microparticles Encapsulated in Biodegradable, Injectable Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels." J. Controlled Release, 91 (2003): 299-313.
R.G. Payne, J.S. McGonigle, M.J. Yaszemski, A.W. Yasko, A. G. Mikos "Development of an Injectable, In Situ Crosslinkable, Degradable Polymeric Carrier for Osteogenic Populations. Part 3. Proliferation and Differentiation of Encapsulated Marrow Stromal Osteoblasts Cultured on Crosslinking Poly(Propylene Fumarate)." Biomaterials, 23 (2002): 4381-4387.
R.G. Payne, J.S. McGonigle, M.J. Yaszemski, A.W. Yasko, A. G. Mikos
"Development of an Injectable, In Situ Crosslinkable, Degradable Polymeric Carrier for Osteogenic Populations. Part 2. Viability of Encapsulated Marrow Stromal Osteoblasts Cultured on Crosslinking Poly(Propylene Fumarate),"." Biomaterials, 23 (2002): 4373-4380.
M.D. Timmer, C.G. Ambrose, and A.G. Mikos, "In Vitro Degradation of Polymeric Networks of Poly(Propylene Fumarate) and the Crosslinking Macromer Poly(Propylene Fumarate)-Diacrylate." Biomaterials, 24 (2003): 571-577.
R.G. Payne, M.J. Yaszemski, A.W. Yasko, A. G. Mikos "Development of an Injectable, In Situ Crosslinkable, Degradable Polymeric Carrier for Osteogenic Cell Populations. Part 1. Encapsulation of Marrow Stromal Osteoblasts in Surface Crosslinked Gelatin Microparticles." Biomaterials, 23 (2002): 4359-4371.
Book
J.P. Fisher, A.G. Mikos, and J.D. Bronzino "Tissue Engineering." (2007).
J.S. Temenoff and A.G. Mikos, Biomaterials: The Intersection of Biology and Materials Science, Pearson Prentice Hall, Upper Saddle River, 2008.
A.G. Mikos, "NWO/Huygens Lecture 2003: Tissue Engineering." (2003).
J.J. Mao, G. Vunjak-Novakovic, A.G. Mikos, and A. Atala Translational Approaches in Tissue Engineering and Regenerative Medicine, Artech House, Norwood, 2008.
F. Bronner, M.C. Farach-Carson, and A.G. Mikos "Engineering of Functional Skeletal Tissues." Topics in Bone Biology, 3 (2007).
Book chapter
L. Klouda, J.D. Kretlow, and A.G. Mikos, Tailored Biomaterials for Tissue Engineering Needs and their Clinical Translation, in Translational Approaches in Tissue Engineering and Regenerative Medicine, J.J. Mao, G. Vunjak-Novakovic, A.G. Mikos, and A. Atala, Eds., Artech House, Norwood, 2008, pp. 325-337.
J.K.V. Tessmar, T.A. Holland, and A.G. Mikos "Salt Leaching for Polymer Scaffolds: Laboratory-Scale Manufacture of Cell Carriers." Scaffolding in Tissue Engineering (2006): 111-124.
S. van Gaalen, M. Kruyt, G. Meijer, A.S. Mistry, A.G. Mikos, J. van den Beucken, J.A. Jansen, K. de Groot, R. Cancedda, C. Olivo, M.J. Yaszemski, and W. Dhert, Tissue Engineering of Bone, in Tissue Engineering, C. van Blitterswijk, Ed., Elsevier Academic Press, San Diego, 2008, pp. 559-610.
M.B. Murphy and A.G. Mikos "Polymer Scaffold Fabrication." Principles of Tissue Engineering, 3rd Ed (2007): 309-321.
S. Young, K.A. Athanasiou, A.G. Mikos, and M.E.-K. Wong "Oral and Maxillofacial Surgery." Principles of Tissue Engineering, 3rd Ed (2007): 1079-1094.
A. Saraf, M. Hacker, and A.G. Mikos "Synthesis of a Poly(Ethylenimine) Conjugate of Hyaluronic Acid for Gene Delivery Applications." Trans. Control. Rel. Soc., 33 (2006): 934.
A.S. Mistry, X. Shi, and A.G. Mikos "Nanocomposite Scaffolds for Tissue Engineering." Tissue Engineering (2007): 11.1-11.11.
X. Shi and A.G. Mikos "Poly(Propylene Fumarate)." An Introduction to Biomaterials (2006): 205-218.
F.K. Kasper, J. Liao, J.D. Kretlow, V.I. Sikavitsas, and A.G. Mikos, Flow Perfusion Culture of Mesenchymal Stem Cells for Bone Tissue Engineering, in StemBook: Tissue Engineering, S. Bhatia and J. Polak, Eds., Harvard Stem Cell Institute, Cambridge, 2008, doi/10.3824/stembook.1.18.1, http://www.stembook.org.
L.J. Suggs, S.A. Moore, and A.G. Mikos "Synthetic Biodegradable Polymers for Medical Applications." in Physical Properties of Polymers Handbook (2005).(In Press)
H. Park, J.S. Temenoff, and A.G. Mikos "Biodegradable Orthopaedic Implants." Engineering of Functional Skeletal Tissues, 3 (2007): 55-68.
M.E. Gomes, R.L. Reis, and A.G. Mikos "Bone Tissue Engineering Constructs Based on Starch Scaffolds and Bone Marrow Cells Cultured in a Flow Perfusion Bioreactor." Advanced Materials Forum III, Materials Science Forum, 514-516 (2006): 980-984.
P.Q. Ruhé, O.C. Boerman, F.G.M. Russel, P.H.M. Spauwen, A.G. Mikos, and J.A. Jansen "Controlled Release of rhBMP-2 Loaded Poly(DL-Lactic-co-Glycolic Acid)/Calcium Phosphate Cement Composites In Vivo." Bioceramics 18, Key Engineering Materials, 309-311 (2006): 973-976.
U. Sharma, A.G. Mikos, and S.C. Cowin "Mechanosensory Mechanisms in Bone." Principles of Tissue Engineering, 3rd Ed. (2007): 919-933.
A.S. Mistry, X. Shi, and A.G. Mikos "Nanocomposite Scaffolds for Tissue Engineering." Tissue Engineering and Artificial Organs, The Biomedical Engineering Handbook, Vol. 3, 3rd Ed. (2006): 40–1-40–11.
J.S. Temenoff, F.K. Kasper, and A.G. Mikos "Fumarate-based Macromers as Scaffolds for Tissue Engineering Applications." Topics in Tissue Engineering, 3 (2007): 6.1-6.16.
M.C. Hacker and A.G. Mikos, Synthetic Polymers, in Principles of Regenerative Medicine, A. Atala, R.P. Lanza, J.A. Thomson, and R.M. Nerem, Eds., Elsevier Academic Press, San Diego, 2008, pp. 604-635.
A.G. Mikos, G. Sarakinos, S.M. Leite, J.P. Vacanti, and R. Langer "Laminated Three-Dimensional Biodegradable Foams for Use in Tissue Engineering The Biomaterials Silver Jubilee Compendium: The Best Papers Published in Biomaterials 1980-2004." (2006): 93-100.
H.L. Holtorf, J.A. Jansen, and A.G. Mikos "Modulation of Cell Differentiation in Bone Tissue Engineering Constructs Cultured in a Bioreactor." Tissue Engineering, 585 (2006): 225-241.
E.L. Hedberg, A. Tang, R.S. Crowther, D.H. Carney, A. G. Mikos "Controlled Release of an Osteogenic Peptide from Injectable Biodegradable Polymeric Composites." J. Controlled Release.(In Press)
A.G. Mikos, L. Lu, J.S. Temenoff, and J.K. Tessmar "Synthetic Bioresorbable Polymer Scaffolds." Biomaterials Science: An Introduction to Materials in Medicine, 2nd Ed (2004): 735-749.
A. G. Mikos, G.N. Bancroft "Bone Tissue Engineering by Cell Transplantation." NATO Advanced Study Institute on Polymer Based Systems on Tissue Engineering, Replacement and Regeneration.(In Press)
A. G. Mikos, J. S. Temenoff "Injectable Biodegradable Materials for Orthopaedic Tissue Engineering." NATO Advanced Study Institute on Polymer Based Systems on Tissue Engineering, Replacement and Regeneration.(In Press)
F.K. Kasper and A.G. Mikos "Biomaterials and Gene Therapy." Advances in Chemical Engineering, Vol. 29 (2004): 131-168.
J.S. Temenoff, E.S. Steinbis, and A.G. Mikos "Biodegradable Scaffolds." Orthopedic Tissue Engineering: Basic Science and Practice (2004): 77-103.
L. Lu, J.S. Temenoff, J.K.V. Tessmar, and A.G. Mikos, "Synthetic Bioresorbable Polymer Scaffolds." Biomaterials Science, 2nd Ed. (2003).(In Press)
J.S. Temenoff and A.G. Mikos "Fumarate-Based Macromers as Scaffolds for Tissue Engineering Applications." in Polymeric Materials Encyclopedia, (2005).(In Press)
J.K.V. Tessmar, T.A. Holland, and A.G. Mikos, "Salt Leaching for Polymer Scaffolds ¿ Laboratory-Scale Manufacture of Cell Carriers." Scaffolding in Tissue Engineering (2003).(In Press)
F.K. Kasper and A.G. Mikos, "Biomaterials and Gene Therapy." Molecular and Cellular Foundations of Biomaterials (2003).(In Press)
R.G. Payne , A. G. Mikos "Synthesis of Synthetic Polymers: Poly(Propylene Fumarate)." Methods of Tissue Engineering (2002): 649-652.
A.S. Mistry, X. Shi, and A.G. Mikos "Nanocomposite Scaffolds for Tissue Engineering." in Biomedical Engineering Handbook (2005).(In Press)
E.L. Hedberg and A.G. Mikos, "Biological Polymers for Controlled Drug Delivery Technologies." Controlled Drug Delivery: Fundamentals and Applications, 3rd Ed. (2003).(In Press)
J.S. Temenoff, E.S. Steinbis, and A.G. Mikos, "Biodegradable Scaffolds." Orthopaedic Tissue Engineering: Basic Science and Practice (2003).(In Press)
T.A. Holland and A.G. Mikos, "Biodegradable Polymeric Scaffolds, Improvements in Bone Tissue Engineering through Controlled Drug Delivery." Advances in Biochemical Engineering/Biotechnology (2003).(In Press)
Book review
K.-U. Lewandrowski, D.L. Wise, D.J. Trantolo, J.D. Gresser, M.J. Yaszemski, and D.E. Altobelli, "Tissue Engineering and Biodegradable Equivalents: Scientific and Clinical Applications." J. Controlled Release, 92 (2003): 399-400.
Conference paper
H.L. Holtorf, J.A. Jansen, and A.G. Mikos "Flow Perfusion Culture Induces the Osteoblastic Differentiation of Marrow Stromal Cell-Scaffold Constructs in the Absence of Dexamethasone." Trans. Soc. Biomater. (2005): 30, 346.
F.K. Kasper, T. Kushibiki, Y. Kimura, A.G. Mikos, and Y. Tabata "In Vivo Release of Plasmid DNA from Composites of Oligo(Poly(Ethylene Glycol) Fumarate) and Cationized Gelatin Microspheres." Proceed. Intern. Symp. Control. Rel. Bioact. Mater. (2005): 32, 605.
F.K. Kasper, S.K. Seidlits, M.A. Barry, and A.G. Mikos "In Vitro Release of Plasmid DNA from Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels." Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 32 (2005): 585.
H.L. Holtorf, N. Datta, J.A. Jansen, and A.G. Mikos "Pore Size of Fiber Mesh Scaffolds Affects the Osteoblastic Differentiation of Seeded Marrow Stromal Cells Cultured in a Flow Perfusion Bioreactor." Trans. Soc. Biomater. (2005): 30, 251.
M.C. Hacker, B.B. Ma, J.D. Kretlow, and A.G. Mikos "Novel Macromers for the Fabrication of Injectable, Calcium-Binding Hydrogels." Trans. Soc. Biomater, 31, 26 (2006).
F.K. Kasper, E. Jerkins, K. Tanahashi, M.A. Barry, Y. Tabata, and A.G. Mikos "Characterization of DNA Release from Composites of Oligo(Poly(Ethylene Glycol) Fumarate) and Cationized Gelatin Microspheres In Vitro." Trans. Soc. Biomater, 31,28 (2006).
A. Saraf and A.G. Mikos "Gene Delivery Strategies for Cartilage Tissue Engineering." Adv. Drug Deliv. Rev., 58 (2006): 592-603.
Z.S. Patel, Y. Tabata, and A.G. Mikos "Gelatin Microparticles for the Controlled Release of an Angiogenic and an Osteogenic Growth Factor." Trans. Control. Rel, 33 (2006): 528.
B. Sitharaman, L.A. Tran, R.D. Bolskar, S.D. Flamm, R. Muthupillai, A.G. Mikos, and L.J. Wilson "Gd@(Carbon Nanostructures) as Nanoprobes for Cellular Magnetic Resonance Imaging." Trans. Soc. Biomater, 31, 72 (2006).
T.A. Holland, E.W.H. Bodde, L.S. Baggett, Y. Tabata, A.G. Mikos, and J.A. Jansen "Osteochondral Repair in the Rabbit Model Utilizing Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogel Scaffolds." Trans. Orthop. Res. Soc. (2005): 51, 1365.
F.K. Kasper, S. Young, K. Tanahashi, M.A. Barry, Y. Tabata, J.A. Jansen, and A.G. Mikos "Evaluation of Bone Regeneration by DNA Release from Composites of Oligo(Poly(Ethylene Glycol) Fumarate) and Cationized Gelatin Microspheres in a Critical-Sized Calvarial Defect." Trans. Control. Rel. Soc, 33 (2006): 525.
M.E. Gomes, R.L. Reis, and A.G. Mikos "Bone Marrow Stromal Cells Cultured on Starch Based Three-Dimensional Scaffolds in a Flow Perfusion Bioreactor: A Promising In-Vitro Approach for Obtaining Bone Tissue Substitutes." Trans. Orthop. Res. Soc. (2005): 51, 1743.
C.-Y. Lin, R.M. Schek, A.S. Mistry, X. Shih, A.G. Mikos, P.H. Krebsbach, and S.J. Hollister "Functional Bone Tissue Engineering Using Ex Vivo Gene Therapy and Topology Optimized, Biodegradable Polymer Composite Scaffolds." Trans. Orthop. Res. Soc. (2005): 51, 936.
T.G. Chu, R.L. Stewart, S.J. Warden, C.H. Turner, and A.G. Mikos "A Load-Bearing, Biodegradable BMP Carrier for Bone Regeneration in a Segmental Defect." Trans. Orthop. Res. Soc. (2005): 51, 1750.
X. Shi, J. Hudson, P.P. Spicer, R. Krishnamoorti, J.M. Tour, and A.G. Mikos "Rheological Behavior and Mechanical Reinforcement of Poly(Propylene Fumarate)-Based Single-Walled Carbon Nanotube Composites." Trans. Soc. Biomater. (2005): 30, 66.
M.A. Wettergreen, W. Sun, A.G. Mikos, and M.A.K. Liebschner "Geometric Characterization of Scaffold Building Blocks for Tissue Engineering." Trans. Orthop. Res. Soc. (2005): 51, 1719.
Other
W.T. Godbey, K.K. Wu, and A.G. Mikos "Size Matters: Molecular Weight Affects the Efficiency of Poly(Ethylenimine) as a Gene Delivery Vehicle." J. Biomed. Mater. Res., 45 (1999): 268-275.
W.T. Godbey, K.K. Wu, G.J. Hirasaki, and A.G. Mikos "Improved Packing of Poly(Ethylenimine)/DNA Complexes Increases Transfection Efficiency." Abstr. HSEMB Confer., 17 (February 1999): Abstract 120.
C.A. Vacanti and A.G. Mikos "Letter from the Editors: On Voluntary Standards." Tissue Eng., 4 (1998): 3.
T.A. Horbett, A.G. Mikos, and D.J. Mooney "Special Issue IV on Cells at Interfaces." J. Biomater. Sci., Polym. Ed., Vol. 10, No. 2 (1999).
M.S. Widmer, P.K. Gupta, L. Lu, R.K. Meszlenyi, G.R.D. Evans, K. Brandt, T. Savel, A. Gurlek, C.W. Patrick, Jr., and A.G. Mikos "Manufacture of Porous Biodegradable Polymer Conduits by an Extrusion Process for Guided Tissue Regeneration." Biomaterials, 19 (1998): 1945-1955.
A.G. Mikos "Section Five: Active Implants." Handbook of Biomaterials Evaluation, 2nd ed., A.F. von Recum, Ed., Taylor & Francis, Philadelphia (1999): pp. 383-460.
A.C. Jen, S.J. Peter, and A.G. Mikos "Preparation and Use of Porous Poly(a-Hydroxyester) Scaffolds for Bone Tissue Engineering." Tissue Engineering Methods and Protocols (1999): pp. 133-140.
Q. Liu, S.-L. He, R. Bahulekar, and A.G. Mikos, "Porous Anionic Hydrogels Based on sIPNs of Poly(2-Hydroxyethyl Methacrylate) and Poly(Acrylic Acid)." Trans. Soc. Biomater., 22 (1999): 368.
L. Lu, S.J. Peter, G.N. Stamatas, and A.G. Mikos "Polymeric Delivery Systems for Bone Growth Factors." Polym. Prepr, 40 (1999): 277-278.
S.J. Peter, C.R. Liang, D.J. Kim, M.S. Widmer, and A.G. Mikos "Osteoblastic Phenotype of Rat Marrow Stromal Cells Cultured in the Presence of Dexamethasone, Beta-Glycerolphosphate, and L-Asorbic Acid." J. Cell. Biochem., 71 (1998): 55-62.
S.J. Peter, M.J. Miller, A.W. Yasko, M.J. Yaszemski, and A.G. Mikos "Polymer Concepts in Tissue Engineering." Trans. Acad. Dent. Mater., 13 (1999): 17-22.
G.R.D. Evans, K. Brandt, S. Katz, P. Chauvin, L. Otto, M. Bogle, B. Wang, R.K. Meszlenyi, L. Lu, A.G. Mikos, and C.W. Patrick, Jr. "Bioactive Poly(L-Lactic Acid) Conduits Seeded with Schwann Cells for Peripheral Nerve Regeneration." Exp. Neurol. (in press).
S.J. Peter, M.J. Miller, A.W. Yasko, M.J. Yaszemski, and A.G. Mikos "Polymer Concepts in Tissue Engineering." J. Biomed. Mater. Res., Appl. Biomater., 43 (1998): 422-427.
L.J. Suggs, E.Y. Kao, L.L. Palombo, R.S. Krishnan, M.S. Widmer, and A.G. Mikos "Preparation and Characterization of Poly(Propylene Fumarate-co-Ethylene Glycol) Hydrogels." J. Biomater. Sci., Polym. Ed., 9 (1998): 653-666.
S.J. Peter, P. Kim, A.W. Yasko, M.J. Yaszemski, and A.G. Mikos "Crosslinking Characteristics of an Injectable Poly(Propylene Fumarate)/Beta-Tricalcium Phosphate Paste and Mechanical Properties of the Crosslinked Composite for Use as a Biodegradable Bone Cement." Biomaterials Regulating Cell Function and Tissue Development, 530 (1998): 87-92.
S. Jo, P.S. Engel, and A.G. Mikos "Synthesis of Poly(Ethylene Glycol)-Tethered Poly(Propylene-co-Fumarate) and Its Modification with GRGD Peptide." Polymer (2000): 7595-7604.
S.J. Peter, L. Lu, D.J. Kim, G.N. Stamatas, M.J. Miller, M.J. Yaszemski, and A.G. Mikos "Effects of Transforming Growth Factor-b1 Released from Biodegradable Polymer Microparticles on Marrow Stromal Osteoblasts Cultured on Poly(Propylene Fumarate) Substrates,"." J. Biomed. Mater. Res. (2000): 452-462.
W.T. Godbey, K.K. Wu, and A.G. Mikos "Tracking the Intracellular Path of Poly(Ethylenimine)/DNA Complexes for Gene Delivery." |