Department of Bioengineering:

B.S. (summa cum laude) (1984) New York Institute of Technology

M.S. (1985) Columbia University

Ph.M. (1988) Columbia University

Ph.D. (1988) Columbia University

Licensed Professional Engineer Texas State Board of Registration for Professional Engineers

Areas of research: Tissue engineering of cartilage, cytomechanics, biomechanics

Email: athanasiou@rice.edu
Phone: 713.348.6385
Office: Room 212 Keck Hall

Musculoskeletal Bioengineering Laboratory

Kyriacos Athanasiou
Adjunct Professor of Bioengineering

MUSCULOSKELETAL BIOENGINEERING LABORATORY: The main objective of the laboratory is to understand and enhance the healing processes of cartilage. Indeed, successful cartilage regeneration continues to be the most vexing problem in musculoskeletal medicine. Following trauma (such as sports injuries) or pathologic affliction (such as osteoarthritis), cartilage is unable to heal itself in a way that would allow it to function properly under its strenuous and biomechanically difficult environment.

Of particular interest in our efforts are 1) hyaline articular cartilage, found in diarthrodial joints such as the knee, hip, and shoulder, 2) menisci, in the knee and temporomandibular joint (TMJ), and 3) fibrocartilage in the TMJ. Our approach entails the use of biodegradable scaffolds designed to incorporate suitable bioactive agents and signals to regenerate cartilage. We also place particular emphasis on certain aspects of scaffold design and overall approach. These include 1) biomechanical characterization of cartilage, 2) cell adhesion to substrata, and 3) attachment and effects of growth factors on chondrocytes.

In terms of cartilage biomechanics, we perform topographical characterizations of articulating surfaces using compressive indentation loading and tensile testing. To this end, we use custom-made instruments which allow us to obtain these tissues' viscoelastic properties. We also develop biomechanical approaches to quantify cartilage structural integrity in vivo and arthroscopically. One of the main issues in scaffold design is to encourage cells to adhere correctly. A significant portion of our efforts centers around the elucidation of mechanisms of cell adhesion, defined as cell attachment, cell spreading, organization of actin cytoskeleton, and formation of focal adhesions. We use cytomechanical techniques to measure the mechanical adhesiveness and mechanical properties of individual cells as a function of peptide substrata. We believe that a deeper understanding and control of cell adhesion will result in better tissue engineered cartilage.

Selected Publications

Abstract

Lavery, L.A.; Higgins, K.R.; Armstrong, D.G.; Holguin, D.; ATHANASIOU, K.A "Randomized clinical trial to evaluate a novel home temperature monitoring device to reduce the incidence of diabetic foot complications." DIABETOLOGIA, 45 (AUG 2003): 1058 Suppl. 2.(Submitted)

Allen, K.; ATHANASIOU, K.A. "Passage effects on temporomandibular joint disc cells.." Annals of Biomedical Engineering (2005).

Leipzig, N.D.; ATHANASIOU, K.A. "Material properties of single chondrocytes under unconfined compression." Orthopaedic Research Society (2004).

Johns, D., ATHANASIOU, K.A. "Improving culture conditions for TMJ disc tissue engineering.." Annals of Biomedical Engineering (2006).

Elder, B.D.; ATHANASIOU, K.A. "The effects of growth factors and hydrostatic pressure in cartilage tissue engineering." (2008).

Uthamanthil, R.K.; ATHANASIOU, K.A.: "In vitro tissue engineering of the knee meniscus: Evaluation of scaffold materials.." Biomaterials (2006).(Submitted)

Eleswarapu, S.V.; Shieh, A.C.; ATHANASIOU, K.A. "Gene expression of single chondrocytes." Orthopaedic Research Society (2004).

Uthamanthil, R.K.; ATHANASIOU, K.A. "Effect of passage and expansion on the tissue engineering potential of meniscal fibrochondrocytes.." Annals of Biomedical Engineering (2005).

Revell, C.M.; Dietrich, J.A.; Scott, C.C.; Luttge, A.; ATHANASIOU, K.A. "Fibroblast morphology characterization on bioactive surfaces using vertical scanning interferometry.." Annals of Biomedical Engineering (2005).

Eleswarapu, S.V.; Leipzig, N.D.; ATHANASIOU, K.A. "Factors influencing the gene expression of single chondrocytes.." Annals of Biomedical Engineering (2005).

Detamore, M.S.; Hegde, J.N.; Wagle, R.R.; Almarza, A.J.; ATHANASIOU, K.A.: "Topographical distribution and sub-populations of cells in the porcine temporomandibular joint disc." Annals of Biomedical Engineering (2003).(Submitted)

Shieh, A.C.; ATHANASIOU, K.A "Viscoelastic properties of zonal chondrocytes." Annals of Biomedical Engineering (2003).(Submitted)

Darling, E.; Hu, J.C.Y.; ATHANASIOU, K.A "Zonal and topographical differences in articular cartilage gene expression." Annals of Biomedical Engineering (2003).(Submitted)

Uthamanthil, R.K.; Edwards, R.B.; Lu, Y.; Thomas, J.B.; ATHANASIOU, K.A.; Markel, M.D. "A long term biomechanical study of mechanical debridement versus thermal chondroplasty using radiofrequency energy for treatment of experimentally induced cartilage injury in an equine model.." Orthopaedic Research Society (2004).

Detamore, M.S.; ATHANASIOU, K.A. "Effects of four growth factors on TMJ Disc cells." Annals of Biomedical Engineering (2004).

Darling, E.M.; ATHANASIOU, K.A. "Effect of cell passaging on chondrocyte gene expression." Orthopaedic Research Society (2004).

Almarza, A.J.; Bean, A.; ATHANASIOU, K.A. "Biochemical content and distribution in the temporomandibular joint disc." Annals of Biomedical Engineering (2004).

Leipzig, N.D.; ATHANASIOU, K.A "Biomechanical response of single chondrocytes to growth factors." Annals of Biomedical Engineering (2004).

Detamore, M.S.; ATHANASIOU, K.A. "Effects of a rotating bioreactor for TMJ disc tissue engineering.." Annals of Biomedical Engineering (2005).

Scott, C.C.; Hayman, D.; ATHANASIOU, K.A. "Characterization of articular cartilage explants: Biochemical, biomechanical, and genetic expression." Annals of Biomedical Engineering (2004).

AufderHeide, A.; ATHANASIOU, K.A. "Effects of direct compression on gene expression of articular cartilage and the knee meniscus.." Annals of Biomedical Engineering (2005).

Darling, E.M.; ATHANASIOU, K.A. "Rapid phenotypic changes in passaged articular chondrocyte subpopulations." Annals of Biomedical Engineering (2004).

Darling, E.M.; ATHANASIOU, K.A. "Retaining zonal chondrocyte phenotype using novel growth environments." Annals of Biomedical Engineering (2004).(Submitted)

Almarza, A.J.; ATHANASIOU, K.A. "Seeding techniques and scaffolding choice for the tissue engineering of the TMJ Disc." Annals of Biomedical Engineering (2004).

Allen, K.; ATHANASIOU, K.A. "A tissue engineering comparison of scaffolding biomaterials for the TMJ disc.." Annals of Biomedical Engineering (2005).

Hoben, G.M.B; Hu, J.; ATHANASIOU, K.A. "Self assembly of meniscal fibrochondrocytes for tissue engineering of the knee meniscus." Annals of Biomedical Engineering (2005).

Allen, K.D.; ATHANASIOU, K.A. "Surface-regional, viscoelastic characterization of the porcine TMJ disc under unconfined compression." Annals of Biomedical Engineering (2004).

Uthamanthil R. K., ATHANASIOU, K.A. "Effects of TGF-β1 and low fetal bovine serum concentration on in vitro tissue engineering of the knee meniscus.." Annals of Biomedical Engineering (2006).

Scott, C.; Volz, T.; ATHANASIOU, K.A "Learning how to teach continuum biomechanics: See one, do one, teach one." Annals of Biomedical Engineering (2003).(Submitted)

Scott, C.; Luttge, F.; C, K.A "Interferometry of single chondrocytes to acquire three-dimensional geometry." Annals of Biomedical Engineering (2003).(Submitted)

Allen, K.D.; ATHANASIOU, K.A "Effect of passage and topography on gene expression of TMJ disc cells." (2006).

Hu, J.C.Y.; ATHANASIOU, K.A "Effect of scaffold microenvironment on low-denisty chondrocyte bioreactor culture." Annals of Biomedical Engineering (2003).(Submitted)

Natoli, R.M.; Revell, C.R.; ATHANASIOU, K.A. "Chondroitinase-ABC treatment results in increased tensile properties in a scaffold-less, serum-free model of articular cartilage tissue engineering." Orthopaedic Research Society (2008).

ATHANASIOU, K.A. "Toward tissue engineering of musculoskeletal cartilages.." Annals of Biomedical Engineering (2005).

Ofek, G; Gunja, N.; Huang, X.; Gao, J.; ATHANASIOU, K.A.; Yao, J. "Development and characterization of an injectable and biodegradable microsphere-co-hydrogel system for chondroitin sulfate delivery." Orthopaedic Research Society (2008).

Allen, K.D.; Detamore, M.S.; ATHANASIOU, K.A. "Tensile and compressive characterization of the TMJ disc using incremental stress relaxation methods." 21st Annual Houston Conference on Biomedical Engineering Research (2004/02).

Article

Gunja, N.J.; ATHANASIOU, K.A.: "A survey of salient biodegradable ACL interference screws." The Anterior Cruciate Ligament: Reconstruction and Basic Science (2008).

Johns, D.E. and ATHANASIOU, K.A. "Clinically-relevant cell sources for TMJ disc engineering." Journal of Dental Research, Res, 87(6) (2008): 548-552.

Hu, J.C., ATHANASIOU, K.A "Zonal chondrocytes exhibit phenotypic differences in high density culture.." Connective Tissue Research (2006).(In Press)

Allen, K.D., ATHANASIOU, K.A. "Viscoelastic characterization of the porcine temporomandibular joint disc under unconfined compression.." Journal of Biomechanics, 39 (2006): 312-322.

Allen, K.D.; ATHANASIOU, K.A. "Tissue engineering the TMJ disc." Tissue Engineering (2006).

Leipzig, N.; Eleswarapu, S.V.; ATHANASIOU, K.A. "The effects of TGF-beta1 and IGF-I on the biomechanics and cytoskeleton of single chondrocytes.." Osteoarthritis and Cartilage (2006).

Hayman, D.M., Blumberg, T.J., Scott, C.C., ATHANASIOU, K.A. "The effects of isolation on chondrocyte gene expression.." Tissue Engineering, 12(9) (2006).(In Press)

Hu, J.C.; ATHANASIOU, K.A. "The effects of intermittent hydrostatic pressure on self-assembled articular cartilage constructs.." Tissue Engineering, 12(5) (2006).

Lavery, L.A.; Lanctot, D.R.; Constantinides, G.P.; Zamorano, R.G.; ATHANASIOU, K.A.; Agrawal, C.M. "Wear and biomechanical characteristics of a novel shear reducing insole with implications for high-risk persons with diabetes.." Diabetes Technology & Therapeutics (2005).(In Press)

Hu, J.C.; ATHANASIOU, K.A. "Zonal chondrocytes exhibit phenotypic differences in high density culture.." Connective Tissue Research (2005).(Submitted)

Aufderheide, A.; ATHANASIOU, K.A "A direct compression stimulator for articular cartilage and meniscal explants.." (2006).

Hu, J.C., ATHANASIOU, K.A. "A self-assembling process in articular cartilage tissue engineering." Tissue Engineering, 12(4) (2006): 969-979.

Gunja, N., ATHANASIOU, K.A. "Biodegradable materials in arthroscopy." Biomaterials in Sports Medicine Issue (2006).

Detamore, M.S., Hegde, J.N.; Wagle, R.R.; Almarza, A.J., Montufar-Solis, D., Duke, P.J., ATHANASIOU, K.A., "Cell type and distribution in the porcine temporomandibular joint disc.." Journal of Oral and Maxillofacial Surgery, 64 (2006): 243-248.

Revell, C.M.; Dietrich, J.; Scott, C.C.; Luttge, A.; ATHANASIOU, K.A "Characterization of fibroblast morphology on bioactive surfaces using vertical scanning interferometry.." (2006).(In Press)

Johns, D.E.; ATHANASIOU, K.A. "Design characteristics for TMJ disc tissue engineering: Learning from tendon and articular cartilage.." Journal of Engineering in Medicine (2006).(In Press)

Scott, C.C., ATHANASIOU, K.A. "Design, validation, and utilization of an articular cartilage impact instrument.." Journal of Engineering in Medicine (2006).

Wang, L.; Kalu, D.N.; Banu, J.; Thomas, J.B.; Gabriel, N.; ATHANASIOU, K.A.: "Effects of aging on the biomechanical properties of rat articular cartilage.." Journal of Engineering in Medicine (2006): 573-578.

Bean, A.C.; Almarza, A.J.; ATHANASIOU, K.A. "Effects of ascorbic acid concentration for the tissue engineering of the temporomandibular joint disc.." Journal of Engineering in Medicine, 220 (2006): 439-447.

Almarza, A.J.; ATHANASIOU, K.A. "Effects of hydrostatic pressure on TMJ disc cells." Tissue Engineering, 12(5) (2006).(In Press)

Eleswarapu, S.V.; Leipzig, N.; ATHANASIOU, K.A. "Gene expression of single articular chondrocytes.." Cell and Tissue Research (2006).

Scott, C.C.; Hayman, D.; ATHANASIOU, K.A. "Gene expression, biochemical, and biomechanical changes in articular cartilage explant culture.." Annals of Biomedical Engineering (2006).

Aufderheide, A.; ATHANASIOU, K.A.: "Growth factor effects on articular cartilage, tendon, ligament, and the knee meniscus.." Journal of Engineering in Medicine (2006).(Submitted)

Allen, K.D.; ATHANASIOU, K.A "Growth factor effects on passaged TMJ disc cells in monolayer and pellet cultures.." , 9(3) (2006): 143-52.

Uthamanthil, R.K.; Edwards, R.B.; Lu, Y.; Manley, P.A.; ATHANASIOU, K.A.; Markel, M.D.: "In vivo study on the short-term effect of radiofrequency energy on chondromalacic patellar cartilage and its correlation with calcified cartilage pathology in an equine model.." Journal of Orthopaedic Research, 24 (2006): 716-724.

Scott, C.C., Volz, T., ATHANASIOU, K.A. "Learning how to teach continuum biomechanics: See one,do one,teach one.." Journal of Engineering Education, 22(1) (2006): 183-187.

Scott, C.C.; ATHANASIOU, K.A. "Mechanical impact and articular cartilage." Critical Reviews in Biomedical Engineering, (2006).(Submitted)

Hoben, G.M., ATHANASIOU, K.A. "Meniscal repair with fibrocartilage engineering.." Sports Medicine and Arthroscopy Review (Biomaterials in Sports Medicine Issue) (2006).

Lavery, L.; Higgins, K.R.; Lanctot, D.R.; Constantinides, G.P.; Zamorano, R.G.; ATHANASIOU, K.A., Armstrong, D.G.; Agrawal, C.M "Preventing diabetic foot ulcer recurrence in high risk diabetic patients: the use of temperature monitoring as a self-assessment tool.." Diabetes Care (2006).

Scott, C.C.; Natoli, R.; ATHANASIOU, K.A. "Temporal effects of mechanical impact on articular cartilage.." Osteoarthritis and Cartilage (2006).(Submitted)

Fleischli, J.G.; Laughlin, T.J.; ATHANASIOU, K.A.; Lanctot, D.R.; Lavery, L.; Wang, X.; Agrawal, C.M: "The effect of diabetes mellitus on the material properties of the distal tibia.." Journal of American Podiatric Medical Association, 96(2) (2006): 91-95.

Allen, K.D.; Erickson, K.; ATHANASIOU, K.A.: "The effects of protein coated surfaces on passaged porcine TMJ disc cells." Archives of Oral Biology, 53 (2008): 53-59.

Hoben, G.M.; ATHANASIOU, K.A. "Use of staurosporine, an actin modifying agent, to enhance fibrochondrocyte matrix gene expression and synthesis." Cell and Tissue Research (2008).

Darling, E.M.; ATHANASIOU, K.A. "Growth factor impact on articular cartilage subpopulations." Cell and Tissue Research (27(2005):1-11.).

AufderHeide, A.; ATHANASIOU, K.A. "A comparison of scaffolds and culture conditions for tissue engineering of the knee meniscus." Tissue Engineering.(Submitted)

Lo, K.Y.; Burkhart, S.S.; ATHANASIOU, K.A. "Abrasion resistance of two types of non-absorbable braided sutures." Arthroscopy: The Journal of Arthroscopic and Related Surgery.(Submitted)

Almarza, A.J.; Bean, A.; Baggett, S.; ATHANASIOU, K.A. "Biochemical characteristics of the porcine temporomandibular joint disc." British Journal of Oral and Maxillofacial Surgery.(Submitted)

Sweigart, M.A.; ATHANASIOU, K.A. "Biomechanical characteristics of the normal medial and lateral porcine knee menisci.." Journal of Engineering in Medicine.(Submitted)

Detamore, M.S.; Hegde, J.N.; Wagle, R.R.; Almarza, A.J.; Montufar-Solis, D.; Duke, P.J.; ATHANASIOU, K.A. "Cell type and distribution in the porcine temporomandibular joint disc." Journal of Oral and Maxillofacial Surgery.(Submitted)

Edwards, R.B.; Uthamanthil, R.K.; Lu, Y.; Bogdanske, J.J.; ATHANASIOU, K.A.; Markel, M.D. "Comparison of mechanical debridement and radiofrequency energy for chondroplasty in an in vivo equine model of partial thickness cartilage injury." Journal of Bone and Joint Surgery [Am]..(Submitted)

Pangborn, A.C.; ATHANASIOU, K.A. "Effects of growth factors on meniscal fibrochondrocytes in monolayer cultures." Tissue Engineering.(Submitted)

Pangborn, A.C.; ATHANASIOU, K.A. "Effects of growth factors on meniscal fibrochondrocytes in three dimensional cultures." Journal of Orthopaedic Research.(Submitted)

Detamore, M.S.; ATHANASIOU, K.A. "Evaluation of three growth factors for TMJ disc tissue engineering." Annals of Biomedical Engineering.(Submitted)

Darling, E.M.; ATHANASIOU, K.A. "Growth factor impact on articular cartilage subpopulations." Annals of Biomedical Engineering.(Submitted)

Sweigart, M.A.; Zhu, C.F.; Burt, D.M.; deHoll, P.D.; Agrawal, C.M.; Clanton, T.C.; ATHANASIOU, K.A. "Interspecies comparison of the creep indentation biomechanics of the medial meniscus." Annals of Biomedical Engineering.(In Press)

AufderHeide, A.; ATHANASIOU, K.A. "Mechanical stimulation toward tissue engineering of the knee meniscus." Annals of Biomedical Engineering.(In Press)

Detamore, M.S.; Orfanos, J.G.; Almarza, A.J.; French, M.M.; Wong, M.E.; ATHANASIOU, K.A. "Quantitative analysis and comparative regional investigation of the extracellular matrix of the porcine temporomandibular joint disc." Matrix Biology.(Submitted)

Darling, E.; ATHANASIOU, K.A. "Rapid phenotypic changes in passaged articular chondrocyte subpopulations." Journal of Orthopaedic Research.(Submitted)

Pangborn, C.; ATHANASIOU, K.A. "The knee meniscus." Wiley Encyclopedia of Biomedical Engineering.(Submitted)

Allen, K.; Detamore, M.; Almarza, A.; Wong, M; ATHANASIOU, K.A. "The temporomandibular joint disc." Wiley Encyclopedia of Biomedical Engineering..(Submitted)

Wong, M; Allen, K.; ATHANASIOU, K.A. "Tissue engineering of the temporomandibular joint." The Biomedical Engineering Handbook, Tissue Engineering Section.(Submitted)

Allen, K.D.; ATHANASIOU, K.A. "Viscoelastic characterization of the porcine temporomandibular joint disc under unconfined compression." Journal of Biomechanics.(Submitted)

Lavery, L.A.; Lanctot, D.R.; Constantinides, G.P.; Zamorano, R.G.; ATHANASIOU, K.A.; Agrawal, C.M "Wear and biomechanical characteristics of a novel shear reducing insole with implications for high-risk persons with diabetes." .(Submitted)

Hoben, G.M.; ATHANASIOU, K.A. "Creating a spectrum of fibrocartilages through different cell sources and biochemical stimuli." Biotechnology and Bioengineering, 100(3): (2008): 587-598,.

Gross-Aviv, T; DiCarlo, B.; French, M.; ATHANASIOU K.A.; and Vago R.: "Crystalline biomaterials for articular cartilage bioengineering." Material Science and Engineering C (2008).(In Press)

Koay, E.J.; Ofek, G.; ATHANASIOU, K.A. "Effects of TGF-�1 and IGF-I on the compressibility, biomechanics, and strain-dependent behavior of single chondrocytes." Journal of Biomechanics, 41 (2008): 1044-1052.

Blumberg T.J.; Natoli R.; ATHANASIOU, K.A. "Effects of doxycycline on articular cartilage GAG release and mechanical properties following impact." Biotechnology and Bioengineering, 100(3) (2008): 506-515.

Gunja, N.J.; ATHANASIOU, K.A. "Effects of hydrostatic pressure on leporine meniscus cell-seeded PLLA scaffolds." Journal of Biomedical Materials Research, Part A (2008).

Revell, C.M.; Reynolds, C.E.; ATHANASIOU, K.A.: "Effects of initial cell seeding in self assembly of articular cartilage." Annals of Biomedical Engineering, 36(9) (2008): 1441-1448.

Natoli, R.M.; Responte, D.; ATHANASIOU, K.A. "Effects of multiple chondroitinase ABC applications on tissue engineered articular cartilage." Journal of Orthopedic Research (2008).

Elder, B.D.; ATHANASIOU, K.A. "Effects of temporal hydrostatic pressure on tissue engineered bovine articular cartilage constructs." Tissue Engineering (2008).

Hoben, G.M.; Koay, E.J.; ATHANASIOU, K.A. "Fibrochondrogenesis in two embryonic stem cell lines: Effects of differentiation timelines." Stem Cells, 26(2) (2008): 422-430.

Hoben, G.M.; Willard, V.; ATHANASIOU, K.A.: "Fibrochondrogenesis of hESCs: Growth factor combinations and co-cultures." Stem Cells and Development (2008).(In Press)

Johns, D.E. and Athanasiou, K.A. "Growth factor effects on costal chondrocytes for tissue engineering fibrocartilage." Cell and Tissue Research, 333 (2008): 439�447.

Koay, E.J.; ATHANASIOU, K.A. "Hypoxic chondrogenic differentiation of human embryonic stem cells enhances cartilage protein synthesis and biomechanical functionality." Osteoarthritis and Cartilage, 16 (2008): 1450-1456.

Ofek, G.; Revell, C.M.; Hu, J.C.; Allison, D.D.; Grande-Allen, K.J.; ATHANASIOU, K.A.: "Matrix development in self-assembly of articular cartilage." PLoS ONE, 3(7) (2008): e2795.

Natoli, R.; ATHANASIOU, K.A. "P188 reduces cell death and IGF-I reduces GAG release following single-impact loading of articular cartilage." Journal of Biomechanics, 130 (2008): 041012-1 - 041012-9.

Elder, B.D.; ATHANASIOU, K.A. "Paradigms of tissue engineering with applications to cartilage regeneration." W. Pietrzak, Ed., Musculoskeletal Tissue Regeneration: Biological Materials and Methods, Chapter 28 (2008): 593-615.

Anderson (Johns), D.E. and ATHANASIOU, K.A. "Passaged goat costal chondrocytes provide a feasible cell source for temporomandibular joint tissue engineering." Annals of Biomedical Engineering, 36(12) (2008): 1992-2001.

Deng, Y., Gunja, N.J., ATHANASIOU, K.A.: "Perspectives and possibilities for degradable polymers for skeletal implants." In Degradable polymers for skeletal implants (2008).

Allen, K.D.; ATHANASIOU, K.A. "Scaffold and growth factor selection in temporomandibular joint disc engineering." Journal of Dental Research, 87(2) (2008): 180-185.

Leipzig, N.; ATHANASIOU, K.A. "Static compression of single chondrocytes catabolically modifies single cell gene expression." Biophysical Journal, 94(6) (2008): 2412-2422.

Revell, C.M., ATHANASIOU, K.A. "Success rates and immunologic responses of autogenic, allogenic, and xenogenic treatments to repair articular cartilage defects." Tissue Engineering, Part B (2008).

Elder, B.D.; ATHANASIOU, K.A. "Synergistic and additive effects of hydrostatic pressure and growth factors on tissue formation." PLoS ONE, 3(6) (2008): e2341.

Natoli, R.; Scott, C.C.; ATHANASIOU, K.A. "Temporal effects of impact on articular cartilage cell death, gene expression, matrix biochemistry, and biomechanics." Annals of Biomedical Engineering, 36(5) (2008): 780-792.

Burkhart, S.S., Athanasiou, K. "The Twist-Lock concept of tissue transport and suture fixation without knots: Observations along the Hong Kong skyline." Arthroscopy: The Journal of Arthroscopic and Related Surgery (2003).

Fleischli, J.G., Laughlin, T.J., Athanasiou, K., Lanctot, D.R., Lavery, L., Wang, X., Agrawal, C.M. "The effect of diabetes mellitus on the material properties of the distal tibia." Journal of Foot and Ankle Surgery (2003).

Lavery, L.A.; Lanctot, D.R.; Constantinides, G.P.; Zamorano, R.G.; ATHANASIOU, K.A. "Agrawal, C.M.: Home monitoring of foot skin temperatures to prevent recurrent ulceration." Diabetes Care, 27 (2004): 2642-2647.

Lo, K.Y.; Burkhart, S.S.; Chan, K.C.; ATHANASIOU, K.A. "Arthroscopic knots: Determining the optimal balance of loop security and knot security." Arthroscopy: The Journal of Arthroscopic and Related Surgery, 20(5) (2004): 489-502.(In Press)

Leipzig, N.; ATHANASIOU, K.A. "Cartilage regeneration." The Encyclopedia of Biomaterials and Biomedical Engineering (2004): 283-291.

French, M.M.; Rose, S.; Canseco, J; ATHANASIOU, K.A. "Chondrogenic differentiation of adult dermal fibroblasts." Annals of Biomedical Engineering, 32(1) (2004): 50-56.

Niederauer, G.G.; Niederauer, G.M.; Cullen, L.C.; ATHANASIOU, K.A.; Thomas, J.B.; Niederauer, M.Q. "Correlation of cartilage stiffness to thickness and level of degeneration using a hand-held indentation probe." Annals of Biomedical Engineering, 32(3) (2004): 352-359.

Almarza, A.; ATHANASIOU, K.A. "Design characteristics for the tissue engineering of cartilaginous tissues." Annals of Biomedical Engineering, 32(1) (2004): 2-17.

Detamore, M.S.; ATHANASIOU, K.A. "Effects of growth factors on temporomandibular joint disc cells." Archives of Oral Biology, 459 (2004): 577-583.

Hu, J.C.Y.; ATHANASIOU, K.A. "Functional assessment of articular cartilage. In Tissue Engineering in Musculoskeletal Clinical Practice." American Academy of Orthopaedic Surgeons (2004): 227-233.

ATHANASIOU, K.A. "Preface to special issue, Annals of Biomedical Engineering." , 32(1) (2004): 1.

Almarza, A.J.; ATHANASIOU, K.A. "Seeding techniques and scaffolding choice for the tissue engineering of the temporomandibular joint disc." Tissue Engineering, 10 (2004): 11-12.

Almarza, A.J.; Detamore, M.S.; Allen, K.D.; ATHANASIOU, K.A. "Tissue engineering concerns and efforts with the TMJ disc." TMJ Science (2004).(In Press)

Darling, E.; Hu, J.C.Y.; ATHANASIOU, K.A. "Zonal and topographical differences in articular cartilage gene expression." Journal of Orthopaedic Research, 22(6) (2004): 1182-1187.

ATHANASIOU, K.A. "Special Issue "Musculoskeletal Bioengineering"." Annals of Biomedical Engineering (2004/03).

Edwards, R.B.; Uthamanthil, R.K.; Lu, Y.; Bogdanske, J.J.; ATHANASIOU, K.A.; Markel, M.D. "1. Comparison of mechanical debridement and radiofrequency energy for chondroplasty in an in vivo equine model of partial thickness cartilage injury. Journal of Bone and Joint Surgery [Am].." (2005).(Submitted)

AufderHeide, A.; ATHANASIOU, K.A "A comparison of scaffolds and culture conditions for tissue engineering of the knee meniscus.." Tissue Engineering, 11(7-8) (2005): 1095-1104.

Allen, K.D.; ATHANASIOU, K.A. "A surface-regional and freeze-thaw characterization of the porcine temporomandibular joint disc.." Annals of Biomedical Engineering, 33(7): (2005): 951-962.

Scott, C.C.; ATHANASIOU, K.A. "Acute effects of mechanical impact on articular cartilage." Osteoarthritis and Cartilage (2005).(Submitted)

Uthamanthil, R.K.; Edwards, R.B.; Manley, P.A.; ATHANASIOU, K.A.: Markel, M.D. "An in vivo study on the short term effect of radiofrequency energy on chondromalacic patellar cartilage and its correlation with calcified cartilage pathology in an equine model." Journal of Orthopaedic Research (2005).(In Press)

Hayman, D.M.; Blumberg, T.J.; Scott, C.C.; ATHANASIOU, K.A. "Articular chondrocyte isolation methods alter gene expression." Tissue Engineering (2005).(Submitted)

Almarza, A.J.; Bean, A.; Baggett, S.; ATHANASIOU, K.A. "Biochemical characteristics of the porcine temporomandibular joint disc.." British Journal of Oral and Maxillofacial Surgery (2005).(In Press)

Lo, K.Y.; Burkhart, S.S.; Chan, K.C.; ATHANASIOU, K.A. "Arthroscopic knots: Determining the optimal balance of loop security and knot security." Arthroscopy: The Journal of Arthroscopic and Related Surgery (2003).(Submitted)

Darling, E.M., Athanasiou, K. "Articular cartilage bioreactors and bioprocesses." Tissue Engineering, 9(1) (2003): 9-26.

Darling, E.M., Athanasiou, K. "Bioactive scaffold design for cartilage engineering." Biomedical Technology and Devices Handbook (2003).(In Press)

Almarza, A.J.; Bean, A.; Baggett, S.; ATHANASIOU, K.A "Biochemical characteristics of the porcine temporomandibular joint disc." Journal of Dental Research (2003).(Submitted)

Darling, E.M., Athanasiou, K. "Biomechanical strategies for articular cartilage regeneration." Annals of Biomedical Engineering (2003).(In Press)

Kim, K., Wong, M.E., Helfrick, J.F., Athanasiou, K. "Biomechanical tissue characterization of the superior joint space of the porcine temporomandibular joint." Annals of Biomedical Engineering (2003).(In Press)

Detamore, M.S.; Hegde, J.N.; Wagle, R.R.; Almarza, A.J.; Montufar-Solis, D.; Duke, P.J.; ATHANASIOU, K.A "Cell type and distribution in the porcine temporomandibular joint disc." Journal of Dental Research (2003).(Submitted)

Koay, E.J., Shieh, A., Athanasiou, K. "Creep indentation of single cells." Journal of Biomechanical Engineering, 125 (2003): 334-341.

French, M.M., Athanasiou, K., N. Ashammakhi, Ed., P. Ferretti, Ed. "Differentiation factors and articular cartilage regeneration." Topics in Tissue Engineering, e-book, http://www.tissue-engineering-oc.com/ebook_topics_in_t_e /kansi.html (2003).

Sweigart, M.A., AufderHeide, A., Athanasiou, K., N. Ashammakhi, Ed., P. Ferretti, Ed. "Fibrochondrocytes and their use in tissue engineering of the meniscus." Topics in Tissue Engineering, e-book, http://www.tissue-engineering-oc.com/ebook_topics_in_t_e /kansi.html (2003).

AufderHeide, A.; ATHANASIOU, K.A "Mechanical stimulation in tissue engineering of the knee meniscus." Annals of Biomedical Engineering. (2003).(Submitted)

Detamore, M.S., Athanasiou, K. "Motivation, characterization and strategy for tissue engineering the temporomandibular joint disc." Tissue Engineering (2003).

ATHANASIOU, K.A.: Editor, Special Issue "Orthopaedic Bioengineering�Basic Issues." Annals of Biomedical Engineering (2003).

ATHANASIOU, K.A.: Editor, Special Issue "Orthopaedic Bioengineering�Regeneration and Clinical Issues." Annals of Biomedical Engineering (2003).

Darling, E.; ATHANASIOU, K.A. "Phenotypic changes in the zonal gene expression of passaged chondrocytes." Science (2003).(Submitted)

Shieh, A., Athanasiou, K. "Principles of cell mechanics for cartilage tissue engineering." Annals of Biomedical Engineering, 31(1) (2003): 1-11.

Wang, L.; Kalu, D.N.; Banu, J.; Thomas, J.B.; Gabriel, N.; ATHANASIOU, K.A "Rodent model of age-related osteoarthritis in humans." Clinical Orthopaedics and Related Research (2003).(Submitted)

Almarza, A.J.; ATHANASIOU, K.A. "Seeding techniques and scaffolding choice for the tissue engineering of the temporomandibular joint disc." Tissue Engineering (2003).(Submitted)

Scott, C.C., Athanasiou, K. "Shear stress and chondrocytes." Biomedical Technology and Devices Handbook (2003).(In Press)

Detamore, M.S., Athanasiou, K. "Structure and function of the temporomandibular joint disc: Implications for tissue engineering." Journal of Oral and Maxillofacial Surgery, 61 (2003): 494-506.

Huang, W., Anvari, B., Torres, J.H., LeBaron, R.G., Athanasiou, K. "Temporal effects of cell adhesion on mechanical characteristics of the single chondrocyte." Journal of Orthopaedic Research, 21(1) (2003): 88-95.

Detamore, M.S., Athanasiou, K. "Tensile properties of the porcine temporomandibular joint disc." Journal of Biomechanical Engineering (2003).(In Press)

Darling, E.; ATHANASIOU, K.A. "Rapid phenotypic changes in passaged articular chondrocyte subpopulations.." Journal of Orthopaedic Research (2005): 425-432.

Scott, C.C.; ATHANASIOU, K.A. "Gene expression, biochemical, and biomechanical changes in articular cartilage explant culture.." Connective Tissue Research (2005).(Submitted)

Scott, C.C.; ATHANASIOU, K.A. "Mechanical impact and articular cartilage.." Critical Reviews in Biomedical Engineering (2005).(Submitted)

Almarza, A.J.; ATHANASIOU, K.A. "Evaluation of three growth factors in combinations of two for TMJ disc tissue engineering." Archives of Oral Biology (2005).(In Press)

Detamore, M.S.; Orfanos, J.G.; Almarza, A.J.; French, M.M.; Wong, M.E.; ATHANASIOU, K.A. "Quantitative analysis and comparative regional investigation of the extracellular matrix of the porcine temporomandibular joint disc.." Matrix Biology, 24 (2005): 45-57.

Lavery, L.; Higgins, K.R.; Lanctot, D.R.; Constantinides, G.P.; Zamorano, R.G.; ATHANASIOU, K.A.; Armstrong, D.G.; Agrawal, C.M "Preventing diabetic foot ulcer recurrence in high risk patients: the use of temperature monitoring as a self-assessment tool." Lancet (2005).(In Press)

Shieh, A.; ATHANASIOU, K.A. "Musculoskeletal cell mechanics." Wiley Encyclopedia of Biomedical Engineering (2005).(In Press)

Sweigart, M.; ATHANASIOU, K.A. "Biochemical properties of the medial rabbit meniscus." (2005).(Submitted)

Sweigart, M.A.; ATHANASIOU, K.A. "Biomechanical characteristics of the normal medial and lateral porcine knee menisci.." Journal of Engineering in Medicine, 219 (2005): 53-62.

Shieh, A.C.; ATHANASIOU, K.A. "Biomechanics of single zonal chondrocytes." Journal of Biomechanics (2005).(In Press)

Revell, C.M.; Dietrich, J.; Scott, C.C.; Luttge, A.; ATHANASIOU, K.A. "Characterization of fibroblast morphology on bioactive surfaces using vertical scanning interferometry.." Matrix Biology (2005).(Submitted)

Scott, C.C.; Luttge, A.; ATHANASIOU, K.A: "Development and validation of vertical scanning interferometry as a novel method for acquiring chondrocyte geometry." Journal of Biomedical Materials Research, Part A, 72A(1) (2005): 83-90.

Hu, J.C.Y.; ATHANASIOU, K.A. "Effect of scaffold microenvironment on low-density chondrocyte bioreactor culture." Biomaterials, 26(14) (2005): 2001-2012.

Bean, A.C.; Almarza, A.J.; ATHANASIOU, K.A. "Effects of ascorbic acid concentration for the tissue engineering of the temporomandibular joint disc.." Journal of Engineering in Medicine (2005).

Pangborn, A.C.; ATHANASIOU, K.A. "Effects of growth factors on meniscal fibrochondrocytes in monolayer cultures.." Tissue Engineering, 11(7-8) (2005): 1141-1148.

Almarza, A.J.; ATHANASIOU, K.A. "Effects of initial seeding density for the tissue engineering of the temporomandibular joint disc.." Annals of Biomedical Engineering, 33(7) (2005): 943-950.

Detamore, M.S.; ATHANASIOU, K.A. "Evaluation of three growth factors for TMJ disc tissue engineering.." Annals of Biomedical Engineering, 33(3) (2005): 383-390.

Scott, C.C.; Volz, T.; ATHANASIOU, K.A. "Learning how to teach continuum biomechanics: See one, do one, teach one." Journal of Engineering Education (2005).(In Press)

Allen, K.D.; ATHANASIOU, K.A. "Viscoelastic characterization of the porcine temporomandibular joint disc under unconfined compression.." Journal of Biomechanics (2005).(In Press)

Detamore, M.S.; ATHANASIOU, K.A. "Use of a rotating bioreactor toward tissue engineering of the temporomandibular joint disc." Tissue Engineering, 11(7-8) (2005): 1188-1197.

Leipzig, N.D.; ATHANASIOU, K.A. "Unconfined creep compression of chondrocytes.." Journal of Biomechanics, 38(1) (2005): 77-85.(In Press)

Leipzig, N.D.; ATHANASIOU, K.A. "Unconfined creep compression of chondrocytes." Journal of Biomechanics, 38(1) (2005): 77-85.

Wong, M; Allen, K.; ATHANASIOU, K.A. "Tissue engineering of the temporomandibular joint. The Biomedical Engineering Handbook,." Tissue Engineering Section (2005).(In Press)

Allen, K.; Detamore, M.; Almarza, A.; Wong, M; ATHANASIOU, K.A. "The temporomandibular joint disc.." Wiley Encyclopedia of Biomedical Engineering. (2005).(In Press)

Pangborn, C.; ATHANASIOU, K.A. "The knee meniscus.." Wiley Encyclopedia of Biomedical Engineering (2005).(In Press)

Hu, J.C.; ATHANASIOU, K.A. "The effects of intermittent hydrostatic pressure on self-assembled articular cartilage constructs.." Tissue Engineering (2005).(Submitted)

Leipzig, N.; Eleswarapu, S.V.; ATHANASIOU, K.A. "The effects of TGF-beta1 and IGF-I on the biomechanics and cytoskeleton of single chondrocytes.." Journal of Cellular Physiology (2005).(Submitted)

Fleischli, J.G.; Laughlin, T.J.; ATHANASIOU, K.A.; Lanctot, D.R.; Lavery, L.; Wang, X.; Agrawal, C.M "The effect of diabetes mellitus on the material properties of the distal tibia." Journal of American Podiatric Medical Association (2005).(In Press)

Pangborn, A.C.; ATHANASIOU, K.A. "Growth factors and fibrochondrocytes in scaffolds." Journal of Orthopaedic Research, 23(5) (2005): 1184-1190.

Sweigart, M.A.; ATHANASIOU, K.A. "Tensile and compressive properties of the medial rabbit meniscus." Journal of Engineering in Medicine, 219(5) (2005): 337-348.

Scott, C.C.; Natoli, R.; ATHANASIOU, K.A. "Temporal effects of mechanical impact on articular cartilage.." Arthritis and Rheumatism (2005).(Submitted)

Shieh, A.C.; Koay, E.J. ; ATHANASIOU, K.A. "Strain-dependent recovery behavior of single chondrocytes." Biomechanics and Modeling in Mechanobiology (2005).(In Press)

Wang, L.; Kalu, D.N.; Banu, J.; Thomas, J.B.; Gabriel, N.; ATHANASIOU, K.A. "Rodent model of age-related osteoarthritis in humans.." Journal of Engineering in Medicine (2005).(In Press)

Darling, E.; ATHANASIOU, K.A. "Retaining zonal chondrocyte phenotype using novel growth environments." Tissue Engineering, 11:3-4 (2005): 395-403.

Book

ATHANASIOU, K.A.; Almarza, A.J.; Detamore, M.; Kalpakci, K. "Tissue Engineering of Temporomandibular Cartilage.." (2008).

ATHANASIOU, K.A.; Sanchez-Adams, J. "Engineering of the Knee Meniscus." (2008).

ATHANASIOU, K.A.; Darling, E.; Hu, J. "Tissue Engineering of Articular Cartilage.." (2008).

ATHANASIOU, K.A.; Natoli, R.: "Introduction to Continuum Biomechanics." (2008).

Book chapter

Elder, B.D.; ATHANASIOU, K.A. "Paradigms of tissue engineering with applications to cartilage regeneration." Musculoskeletal Tissue Regeneration: Biological Materials and,, Chapter 28 (2008): 593-615.

Hu, J.C.Y., Athanasiou, K., "Structure function characteristics of articular cartilage." Handbook of histology methods for bone and cartilage (2003): 73-95.

Johns, D.E., Willard, V.P., Allen, K.D., and ATHANASIOU, K. A. "Is tissue engineering of the TMJ disc a feasible process?." ‘International Conference on TMJ Replacement and Tissue Engineering in Hiroshima’ (2006): 37-47.

Gunja, N.J.; ATHANASIOU, K.A. "A survey of salient biodegradable ACL interference screws.." The Anterior Cruciate Ligament: Reconstruction and Basic Science (2008)).

Conference paper

Detamore, M.S.; ATHANASIOU, K.A "Design criteria for TMJ disc tissue engineering." Annual Meeting of the Tissue Engineering Society International (DEC 2003).(Submitted)

Detamore, M.S.; Orfanos, J.G.; French, M.M.; Wong, M.E.; ATHANASIOU, K.A "Three dimensional identification of key extracellular matrix constituents of the TMJ disc." Annual Meeting of the Tissue Engineering Society International (DEC 2003).(Submitted)

Elder, B.D.; ATHANASIOU, K.A. "The effects of growth factors and hydrostatic pressure in cartilage tissue engineering." (2008).

Ofek, G.; Willard, V.P.; Koay, E.J.; Hu, J.C.; Lin, P.; ATHANASIOU, K.A. "Nanomechanical properties of differentiated single human embryonic stem cells." (October 2008).

Willard, V.P.; Ofek, G.; Koay, E.J.; Hu, J.C.; ATHANASIOU, K.A. "Purification of chondrogenically differentiated hESCs using a Percoll density gradient." (September 2008).

Elder, B.D.; ATHANASIOU, K.A. "The effects of growth factors and hydrostatic pressure in cartilage tissue engineering." (2008).

Green, D.; Noble, P.C.; Ahuero, J.; Birdsall, H.; ATHANASIOU, K.A "Nitric oxide inhibition curtails the zone of damage of articular cartilage after acute mechanical trauma." Orthopaedic Research Society (2003).(Submitted)

French, M.M.; Canseco, J; Rose, S.; Liu, E.; ATHANASIOU, K.A "Matrix stimulated chondrogenesis of dermal fibroblasts." Orthopaedic Research Society (2003).(Submitted)

Navarro, R.A.; ATHANASIOU, K.A "Are bioabsorbable screws absorbing? Results of one medium term explant." 22nd Annual Meeting, Arthroscopy Association of North America (2003).(Submitted)

Elder, B.D.; ATHANASIOU, K.A. "Synergistic and additive effects of hydrostatic pressure and growth factor application on engineered articular cartilage constructs." (2008).

Elder, B.D.; ATHANASIOU, K.A. "Synergistic and additive effects of hydrostatic pressure and growth factor application on engineered articular cartilage constructs." (2008).

Hu, J.C.Y.; French, M.M.; ATHANASIOU, K.A "The use of bioreactors on articular cartilage tissue engineering." Orthopaedic Research Society (2003).(Submitted)

Sweigart, M.A.; ATHANASIOU, K.A "Topographical variations of the medial rabbit meniscus." Orthopaedic Research Society (2003).(Submitted)

Elder, B.D.; ATHANASIOU, K.A. "Hydrostatic pressure enhances biomechanical properties of engineered articular cartilage constructs." (2008).

Natoli, R.M.; ATHANASIOU, K.A. "Engineering articular cartilage with chemical equivalents of hydrostatic pressure." (2008).

Refereed Article

Hoben, G.M.; ATHANASIOU, K.A "Self-assembly of fibrochondrocytes and chondrocytes for tissue engineering of the knee meniscus." Tissue Engineering, 13(5) (2007): 939-946.

Lavery, L.; Higgins, K.R.; Lanctot, D.R.; Constantinides, G.P.; Zamorano, R.G.; ATHANASIOU, K.A.; Armstrong, D.G.; Agrawal, C.M "Preventing diabetic foot ulcer recurrence in high risk diabetic patients: use of temperature monitoring as a self-assessment tool." Diabetes Care, 30(1) (2007): 14-20.

Elder, B.D.; ATHANASIOU, K.A. "Paradigms of tissue engineering with applications to cartilage regeneration,." Musculoskeletal Tissue RegenerationBiological Materials and Methods (2007).

Ofek, G.; ATHANASIOU, K.A. "Micromechanical properties of chondrocytes and chondrons: relevance to articular cartilage tissue engineering." Journal of Mechanics of Materials and Structures (special issue of Mechanics of Biomaterials in Small Length-Scale), 2(6) (2007): 1059-1086.

Ofek. G; ATHANASIOU, K.A. "Matrix development of self-assembled engineered articular cartilage." Annals of Biomedical Engineering (2007).

Deng, Y.; Hu, J.C.; ATHANASIOU, K.A. "Isolation and chondroinduction of a dermis-isolated, aggrecan sensitive subpopulation with high chondrogenic potential." Arthritis & Rheumatism, 56(1) (2007): 168-176.

Uthamanthil, R.K.; ATHANASIOU, K.A. "In vitro tissue engineering of the knee meniscus: Evaluation of scaffold materials." Biomaterials (2007).

Johns, D.; ATHANASIOU, K.A. "Improving culture conditions for TMJ disc tissue engineering." Cells, Tissues, Organs, 185(4) (2007): 246-257.

Koay, E.J.; ATHANASIOU, K.A. "Hypoxic chondrogenic differentiation of human embryonic stem cells enhances cartilage protein synthesis and biomechanical functionality." Arthritis and Rheumatism (2007).

Eleswarapu, S.V.; Leipzig, N.; ATHANASIOU, K.A. "Gene expression of single articular chondrocytes." Cell and Tissue Research, 327(1) (2007): 43-54.

Hoben, G.M.; Koay, E.J.; ATHANASIOU, K.A. "Fibrochondrogenesis in two embryonic stem cell lines: Effects of differentiation." Annals of Biomedical Engineering, (2007).

Koay, E.; ATHANASIOU, K.A. "Effects of serum on human embryonic stem cell-derived fibrochondrogenesis." Annals of Biomedical Engineering (2007).

Elder, B.D.; ATHANASIOU, K.A. "Effects of confinement on the mechanical properties of self-assembled articular cartilage constructs in the direction orthogonal to the confinement surface." Journal of Orthopaedic Research (2007).

Allen, K.D.; ATHANASIOU, K.A. "TMJ disc engineering: Scaffold and growth factor selection." Journal of Dental Research (2007).

Scott, C.C.; Natoli, R.; ATHANASIOU, K.A. "Temporal effects of mechanical impact on articular cartilage." Osteoarthritis and Cartilage (2007).

Wong, M.E.; Young, S.; Mikos, A.; ATHANASIOU, K.A. "Tissue engineering in oral and maxillofacial surgery." Principles of Tissue Engineering, 3rd Edition (2007).

Koay, E.J.; Hoben, G.M.; ATHANASIOU, K.A. "Tissue engineering with chondrogenically-differentiated human embryonic stem cells." Stem Cells, 25 (2007): 2183-2190.

Koay, E.; Ofek, G.; ATHANASIOU, K.A. "Effects of IGF-I and TGF-beta 1 on the strain-dependent recovery behavior of single chondrocytes.." Annals of Biomedical Engineering (2007).

Shieh, A.; ATHANASIOU, K.A. "Dynamic compression of single cells." Osteoarthritis and Cartilage, 15 (2007): 328-334.

Johns, D.E.; ATHANASIOU, K.A. "Design characteristics for TMJ disc tissue engineering: Learning from tendon and articular cartilage." Journal of Engineering in Medicine, 221(H) (2007): 509-526.

Natoli, R.M.; ATHANASIOU, K.A. "Computationally modeling mechanical impact of articular cartilage and the relationship to cell death." Annals of Biomedical Engineering (2007).

Edwards, R.B.; Lu, Y.; Uthamanthil, R.K.; Bogdanske, J.J.; Muir, P.; ATHANASIOUK.A.; Markel, M.D "Comparison of mechanical debridement and radiofrequency energy for chondroplasty in an in vivo equine model of partial thickness cartilage injury." Osteoarthritis Cartilage, 15(2) (2007): 169-178.

Aufderheide, A.; ATHANASIOU, K.A. "Assessment of a bovine co-culture, scaffold-free method for growing meniscus-shaped constructs." Tissue Engineering, 13(9) (2007): 2195-2205.

Detamore, M.S.; ATHANASIOU, K.A.Mao, J.J. "A call to action for bioengineers and dental professionals: directives for the future of TMJ bioengineering." Annals of Biomedical Engineering, 35(8) (2007): 1301-1311.

Refereed Conference Paper

Revell, C.R.; ATHANASIOU, K.A. "Defined medium for the self-assembling process: Enhancing functionality of tissue engineered articular cartilage." Proceedings of the ASME 2007 Summer Bioengineering Conference (2007).

Natoli, R.N. ; ATHANASIOU, K.A. "Ameliorating glycosaminoglycan (gag) loss and cell death in articular cartilage following single-impact loading." Proceedings of the ASME 2007 Summer Bioengineering Conference (2007).

Gunja, N. ; ATHANASIOU, K.A. "Effects of hydrostatic pressure on meniscus cell-seeded PLLA scaffolds." Proceedings of the ASME 2007 Summer Bioengineering Conference (2007).

Presentations

Invited Talk

"Biennial meeting of the Hellenic Arthroscopy Association George Noulis with AGA (Arthroscopy Association of German speaking countries) Athens, Greece.".

"Orthopaedic Medical Device Emerging Technology Showcase BioHouston." Houston, TX. (April, 2006)

"Biomedical Engineering Society.". (9/05)

"On Commercialization of university-based biotechnology research." Research Committee of University of Thessaly, Pauo Monastery, Pelion, Greece. (09/2006)

"Department of Orthopaedics." Baylor College of Medicine, Houston, Texas. (5/05 )

"Meeting with Ministerial Committee, including the Minister of Commerce and Industry (George Lilikas), Minister of Education (Pefkios Yeorgiadis), and Minister of Finance (Makis Keravnos)." Nicosia, Cyprus. (5/05 )

"Seminar Speaker, Department of Biomedical Engineering at UC-Davis." Department of Biomedical Engineering University of California at Davis, Davis, CA. (December 2008)

"Invited speaker for the Board of Directors." Arthritis Foundation of Texas, Houston, TX. (December 2008)

"Keck Seminar Series." Rice University, Houston, TX. (December 2008)

"1st Annual University of Wisconsin Stem Cell Technology Symposium." University of Wisconsin, Madison, WI. (September 2008)

"Stem Cell Advances Through Bioengineering." World Stem Cell Summit, Madison, WI. (September 2008)

"Baylor-Rice Consulting and Entrepreneurship Club." Houston, TX. (July 2008)

Keynote Speaker

"Stem Cells and Dental Engineering." International Meeting on Modern Dentistry Oral Pathology, COST, Athens, Greece. (11/05)

"Cyprus Entrepreneurship Comptetition Conference and Award Ceremony." Mr. Antonis Paschalides, Minister of Commerce, Industry, & Tourism (Cyprus); Mr. Christos Folias, Minister of Development (Greece), Greece. (June 2008)

"TMJ Replacement and Tissue Engineering." Hiroshima, Japan. (March, 2006)

Lecture

"Lecturer, Advances in Tissue Engineering Short Course." Rice University Center for Excellence in Tissue Engineering, Houston, TX. (August 2008)

"Invited Instructor: New developments in Bioengineering Technology, Ethics and Law." Glasscock School of Continuing Education at Rice University, Houston, TX. (February 2008)

Other

"Advances in Tissue Engineering." Faculty, Rice University, Houston, Texas. (8/05)

"Ben Gurion University of the Negev." Beer Sheva, Israel. (4/05 )

Seminar Speaker

"Mechanical and Manufacturing Engineering." University of Thessaly, Volos, Greece. (10/2006)

Session Chair

"Tissue Engineering Institute of Bioscience and Bioengineering Symposium." Speaker, Rice University, Houston, Texas. (7/05)

Workshop

"Invited Participant, Segal North American Osteoarthritis Workshop II." Rush University Medical Center, Chicago, IL. (May 2008)

"Invited Participant, Rice Leaders." Rice University, Houston, TX. (May 2008)

Editorial Positions

Other, Research in Veterinary Science, (2004).

Member of the Editorial Board, Journal of Foot and Ankle Surgery, (2005).

Member of the Editorial Board, Clinical Orthopaedics and Related Research, (2005).

Other, Tissue Engineering, (2005).

Book Review Editor, Clinical Orthopaedics and Related Research, (2005).

Other, Journal of Bone and Joint Surgery, (2005).

Book Review Editor, Journal of Foot and Ankle Surgery, (2005).

Book Review Editor, Biotechnology and Bioengineering, (2005).

Book Review Editor, Research in Veterinary Science, (2005).

Book Review Editor, Biomaterials, (2005).

Book Review Editor, Reviewer for Journal of Biomechanics, (2005).

Other, Journal of Biomechanical Engineering, (2005).

Other, Journal of Orthopaedic Research, (2005).

Book Review Editor, Annals of Biomedical Engineering, (2005).

Other, Journal of Biomedical Materials Research, (2005).

Member of the Editorial Board, Evidence-Based Preventive Medicine, (2005).

Associate Editor, Annals of Biomedical Engineering, (2005).

Other, Musculoskeletal Bioengineering, (2005).

Other, posterior tibial tendon dysfunction, (2005).

Other, Orthopaedic Biodegradable Biomaterials, (2005).

Member of the Editorial Board, Tissue Engineering, (2005).

Member of the Editorial Board, Osteoarthritis and Cartilage, (2007).

Associate Editor, Annals of Biomedical Engineering, (2008).

Member of the Editorial Board, Tissue Engineering, (2008).

Series Editor, Tissue Engineering Lecture Book Series, (2008).

Member of the Editorial Board, Tissue Engineering, Part B, (2008).

Member of the Editorial Board, Tissue Engineering, Part C, (2008).

Member of the Editorial Board, Osteoarthritis and Cartilage, (2008).

Theses

Zhiwei Li, Masters. "Membrane Tether Formation from Outer Hair Cells with Optical Tweezers." (2000).

Edward Yonter, Masters. "Gene Therapy Approaches to Alter the Mechanical Properties of Tissue Engineered Constructs." (2000).

Wei Huang, Masters. "The Temporal Effects of Cell Adhesion on the Mechanical Characteristics of the Single Chondrocyte." (2001).

, Ph.D. "Nic Leipzig: Graduate student, Bioengineering." (2004).(Thesis or Dissertation Director)

, Ph.D. "Michael Detamore: Graduate Student, Bioengineering." (2004).(Thesis or Dissertation Director)

, Ph.D. "Eugene Koay: Graduate student, Bioengineering." (2004).(Thesis or Dissertation Director)

, Ph.D. "Chris Revell: Gradute student, Bioegineering." (2004).(Thesis or Dissertation Director)

, Ph.D. "Christine Pangborn: Gradute student, Bioengineering." (2004).(Thesis or Dissertation Director)

, Ph.D. "Kyle Allen: Graduate student, Bioengineering." (2004).(Thesis or Dissertation Director)

, Ph.D. "Corey Scott: Graduate student, Bioengineering." (2004).(Thesis or Dissertation Director)

, Ph.D. "Alejandro Almarza: graduate student, Bioengineering." (2004).(Thesis or Dissertation Director)

, Ph.D. "Adam AufderHeide: Graduate student, Bioengineering." (2004).(Thesis or Dissertation Director)

, Ph.D. "Adrian Shieh: Graduate student, Bioengineering." (2004).(Thesis or Dissertation Director)

, Ph.D. "Jerry Hu: Graduate student, Bioengineering." (2004).(Thesis or Dissertation Director)

, Ph.D. "Mark Sweigart: Graduate Student, Bioengineering." (2004).(Thesis or Dissertation Director)

, Ph.D. "Eric Darling: Graduate Student, Bioengineering." (2004).(Thesis or Dissertation Director)

, "Dr. Jerry Hu Post-doctoral fellow ." (2005).

, "Dr. Hong Kang-Visiting Professor." (2006).

Brandon Bucklen, Ph.D. "Tissue Mechanical Properties as an Optimization Criterion for Improved Tissue Engineering Scaffolds." (2008).(Committee Member)

Simon Young, Ph.D. "The Effect of Simultaneous, Controlled Release of Angiogenic and Osteogenic Growth Factors on the Enhancement of Osteogenesis Within Craniofacial Defects." (2008).(Committee Member)

Zannatul Ferdous, Ph.D. "Collangenous Tissue Engineered Constructs to Study the Role of Decorin on Fibrillogenesis and Tissue Mechanics." (2008).(Committee Member)

Louise Organ, Ph.D. "Investigating the Lateral Mobility of Outer Hair Cell Plasma Membrane Constituents by Fluoresence Recovery After Photobleaching." (2008).(Committee Member)

Deirdre Johns, Ph.D. "Functional Tissue Engineering of the Temporomandibular Joint Disc." (2008).(Thesis or Dissertation Director)

Chris Revell, Ph.D. "Characterization of Chondrocyte Differentiation and Optimization of a Self-Assembling Process for Tissue Engineering of Articular Cartilage." (2008).(Thesis or Dissertation Director)

Benjamin Elder, Ph.D. "Optimizing a Scaffoldless Approach for Cartilage Tissue Engineering." (2008).(Thesis or Dissertation Director)

Najmuddin Gunja, Ph.D. "Exogenous Stimulation of Meniscus Cells for the Purposes of Tissue Engineering the Knee Meniscus." (2008).(Thesis or Dissertation Director)

Roman Natoli, Ph.D. "Impact Loading and Functional Tissue Engineering of Articular Cartilage." (2008).(Thesis or Dissertation Director)

, "Jeremy Lemoine-Ph.D. student, Bioengineering."

, "Wafa Towackoli-Ph.D. student, Bioengineering."

, "Gidon Ofek-Ph.D. student, Bioengineering."

, "Daniel Huey-Ph.D. student, Bioengineering."

, "Vincent Willard -Ph.D. student, Bioengineering."

, "Benjamin Elder-Ph.D. student, Bioengineering."

, "Kerem Kalakci-Ph.D. student, Bioengineering."

, "Roman Natoli-Ph.D. student, Bioengineering."

, "Deirdre Johns-Ph.D. student, Bioengineering."

, "Gwen Hoben-Ph.D. student, Bioengineering."

, "Naj Gunja-Ph.D. student, Bioengineering."

, "Chris Revell-Ph.D. student, Bioengineering."

, "Adam AufderHeide-Ph.D. student, Bioengineering."

, "Kyle Allen Ph.D. student, Bioengineering."

, "Nic Leipzig-Ph.D. Student, Bioengineering."

, "Dr. Rajesh K. Uthamanthil-Post-doctoral fellow."

, "Adrian Shieh-Ph.D. Student, Bioengineering."

, "Kay Sun-Ph.D. student, Bioengineering."

Grants and Proposals

Self-assembling process in tissue engineering of articular cartilage, National Institutes of Health (NIAMS/NIBIB).

TMJ disc regeneration , National Institutes of Health.

Toward tissue engineering of the knee meniscus, National Institutes of Health.

Accreditation and membership support, The Wallace H. Coulter Foundation .

Use of dermis derived cells for articular cartilage tissue engineering , Arthritis Foundation.

Analysis of the OsseoSpeed surface using cytodetachment technology, AstraTech, M�lndal, Sweden.