B.S. Physics and Mathematics (1985) University of Nebraska - Lincoln
M.S. Physics (1987) Massachusetts Institute of Technology
Ph.D. Medical Physics (1990) Massachusetts Institute of Technology
High-resolution, in vivo, optical imaging for enhanced detection of cancer; fluorescence imaging for cancer detection; electro-magnetic modeling of light scattering by cells and tissues; fiber optic sensors for in vivo detection of cancer.
Email: rkortum@rice.edu
Phone: 713-348-5869
Office: BioScience Research Collaborative (BRC), Suite 519
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Rebecca Richards-Kortum
Stanley C. Moore Professor of Bioengineering
For two decades, Rebecca Richards-Kortum has focused on translating research that integrates advances in nanotechnology and molecular imaging with microfabrication technologies to develop optical imaging systems that are inexpensive, portable, and provide point-of-care diagnosis. This basic and translational research is highly collaborative and has led to new technologies to improve the early detection of cancers and other diseases, especially in impoverished settings. Microelectromechanical systems (MEMS) use micro-scale technology to design low-cost, reusable platforms for point-of-care (POC) diagnostics. When used with contrast agents, these rugged and portable optical imaging systems detect molecular signatures of pre-cancer, assess tumor margins, and monitor a patient’s response to therapy. Current systems are being tested and applied through multidisciplinary collaborations with clinicians and researchers at Rice, the UT M.D. Anderson Cancer Center, UT Health Science Center-Houston, UT at Austin, the University of Arizona, and the British Columbia Cancer Agency. Over the past few years, Richards-Kortum and collaborators have translated these technologies from North America to both low- and medium-resource developing countries (Botswana, India, Taiwan, Mexico, and Brazil). Notable awards Richards-Kortum has received include: the Presidential Young Investigator (1991) and Presidential Faculty Fellow (1992) awards from the National Science Foundation; the Becton Dickinson Career Achievement Award from the Association for the Advancement of Medical Instrumentation (1992); named a Howard Hughes Medical Institute (HHMI) Professor (2002); received the Sharon Keillor Award for Women in Engineering Education (2004) and Chester F. Carlson Award (2007) from the American Society for Engineering Education. She served on the inaugural National Advisory Council for Biomedical Imaging and Bioengineering for the National Institutes of Health (2002-2007), was elected fellow of the American Association for the Advancement of Science and Biomedical Engineering Society (2008); received the Vice President Recognition Award by IEEE (2008); and was inducted into the National Academy of Engineers (2008).
Selected Publications
Article
Sung K. Chang, Dizem Arifler, Rebekah Drezek, Michele Follen, Rebecca Richards-Kortum "An Analytical Model to Describe Fluorescence Spectra of Normal and Pre-Neoplastic Epithelial Tissue: Comparison with Monte Carlo Simulations and Clinical Measurements." Journal of Biomedical Optics, 9 (2004): 511-522.
Hsu E, Anslyn E, Dharmawardhane S, Alizadeh-Naderi R, Aaron J, Sokolov K, El-Naggar A, Gillenwater A, Richards-Kortum R "A Far Red Fluorescent Contrast Agent to Image Epidermal Growth Factor Receptor Expression." Photochemistry and Photobiology, 79 (2004): 272-279.
Sokolov K, Follen M, Aaron J, Pavlova I, Malpica A, Lotan R, Richards-Kortum R "Real Time Vital Imaging of Pre-Cancer Using Anti-EGFR Antibodies Conjugated to Gold Nanoparticles." Cancer Research, 63 (2003): 1999-2004.
Konstantin Sokolov, Jesse Aaron, Betsy Hsu, Dawn Nida, Ann Gillenwater, Michele Follen, Calum MacAulay, Karen Adler-Storthz, Brian Korgel, Michael Descour, Renata Pasqualini, Wadih Arap, Wan Lam, Rebecca Richards-Kortum "Optical Systems for In Vivo Molecular Imaging of Cancer." Technology in Cancer Research and Treatment, 2 (2003): 491-504.
Benavides JM, Chang S, Park SY, MacKinnon N, MacAulay C, Milbourne A, Malpica A, Follen M, Richards-Kortum R "Multispectral Digital Colposcopy for in vivo Detection of Cervical Cancer." Optics Express, 11 (2003): 1223-36.
T. Collier, A. Lacy, A. Malpica, M. Follen, R. Richards-Kortum "Near Real Time Confocal Microscopy of Amelanotic Tissue: Detection of Dysplasia in Ex-Vivo Cervical Tissue." Academic Radiology, 9 (2002): 504-512.
Brookner C., Follen M, Boiko I., Galvan J., Thomsen S., Malpica A., Suzuki S., Lotan R, Richards-Kortum R "Tissue Slices Autofluorescence Patterns in Short-Term Cultures of Normal Cervical Tissue." Photochemistry and Photobiology, 71 (2000): 730-36.
Utzinger U, Brewer M, Silva E, Gershensen D, Bast R, Follen Mitchell M, Richards-Kortum R "Reflectance Spectroscopy for In Vivo Characterization of Ovarian Tissue." Lasers in Surgery and Medicine, 28 (2000): 56-66.
Heintzelman D, Utzinger U, Fuchs H, Gillenwater A, Jacob R, Kemp B, Richards-Kortum R "Optimal Excitation Wavelengths for In Vivo Detection of Oral Neoplasia Using Fluorescence Spectroscopy." Photochemistry and Photobiology, 72 (2000): 103-113.
Drezek R, Collier T, Brookner C, Malpica A, Lotan R, Richards-Kortum R "Laser Scanning Confocal Microscopy of Cervical Tissue Before and After Application of Acetic Acid,." AM J Obstet Gynecol, 182 (2000): 1135-39.
Book chapter
Carlson, A. Richards-Kortum "Optical Technologies for the Detection and Diagnosis of Epithelial Pre-Cancers and Cancers." Encyclopedia of Biomedical Engineering (2005).(Submitted)
Sokolov K., D. Nida, M. Descour, A. Lacy, S. Dharmawardhane, A. Ellington, B. Korgel, R. Richards-Kortum "Molecular Optical Imaging of Therapeutic Targets of Cancer." Genomics in Cancer Drug Development (2006).(In Press)
Conference paper
Roblyer D, Park SY,Adewole I, Follen M, Richards-Kortum, R. "Objective screening for cervical cancer in developing nations: Lessons from Nigeria." Gynecol Oncol, PMID: 17825396 (2007 Sep 5).(In Press)
Guillaud M, Follen M, Richards-Kortum, R "Paradigm shift: A new breed of pathologist." Gynecol Oncol, PMID: 17825391 (2007 Sep 5).(In Press)
Refereed Article
T. Muldoon, S. Anandasabapathy, D. Maru, R. Richards-Kortum, High-resolution imaging in Barrett's Esophagus: a novel, low-cost endoscopic microscope, Gastrointestinal Endoscopy 68 (2008), pp. 737-744 DOI information: 10.1016/j.gie.2008.05.018
Rogers JD, Landau S, Tkaczyk T, Descour MR, Rahman MS, Richards-Kortum R, Karkainen AHO, Christenson T; Imaging Performance of a Miniature Integrated Micro-Endoscope, J. Biomed. Opt., Vol. 13, 054020 (2008); DOI:10.1117/1.2978060
Maitland, KC, A Gillenwater, MD Williams, AK El-Naggar, M Descour, and R Richards-Kortum, In vivo imaging of oral neoplasia using a miniaturized fiber confocal reflectance microscope. Oral Oncol, 2008. 44(11): p. 1059-1066. PMID: 18396445
R. Kester, T. Christenson, R. Richards Kortum, T. Tkaczyk; Low Cost High Performance Self Aligning Miniature Optical Systems, submitted to Applied Optics, 2008
Rahmann, M, Gillenwater A, Richards-Kortum R; Low-Cost, Multi-Modal, Portable Screening System for Early Detection of Oral Cancer, Journal of Biomedical Optics: Letters, J Biomed Opt. 2008 May-Jun;13(3):030502. PMID: 18601519
David J. Javier, Nitin Nitin, Darren M. Roblyer, Rebecca Richards-Kortum. "Metal-based nanorods as molecule specific contrast agents for reflectance imaging in 3D tissues". Journal of Nanophotonics (2008) 2, 023506.
184. Crystal Redden Weber, Richard Schwarz, Edward Atkinson, Dennis Cox, Calum MacAulay, Michele Follen, Rebecca Richards-Kortum; Model-Based Analysis of Reflectance and Fluorescence Spectra for In Vivo Detection of Cervical Dysplasia and Cancer, in press, Journal of Biomedical Optics, 2008
Ina Pavlova, Richard Schwarz, Ann Gillenwater, Rebecca Richards-Kortum; Monte Carlo model to describe depth selective fluorescence spectra of epithelial tissue: Applications to diagnosis of oral precancer, in press, Journal of Biomedical Optics, 2008
van de Ven AL, Adler-Storthz K, Richards-Kortum R. Delivery of molecular-specific optical contrast agents for cancer biomarker detection in live cells and tissues. Abstract. Keck Center Annual Nanobiology Symposium, Houston, TX, 2008
A. van de Ven, K. Adler-Storthz, R. Richards-Kortum. Delivery of Optical Contrast Agents using Triton-X100, Part 2: Enhanced mucosal permeation delivery of topical contrast agents for the detection of cancer biomarkers. In press, Journal of Biomedical Optics, 2008.
189. A. van de Ven, K. Adler-Storthz, R. Richards-Kortum. Delivery of Optical Contrast Agents using Triton-X100, Part 1: Reversible permeabilization of live cells for intracellular labeling. In press, Journal of Biomedical Optics, 2008
Kristen D. Carlson, Ann M. Gillenwater, Michelle Williams, Adel K. El-Naggar, Michael Descour, Rebecca R. Richards-Kortum; Confocal Reflectance Microscopy for Detection of Oral Cavity Neoplasia In Vivo, Oral Oncology, 2008 Apr 5. PMID: 18396445
Sun Young Park, Michele Follen, Andrea Milbourne, Helen Rhodes, Anais Malpica, Nick MacKinnon, Calum MacAulay, Mia Markey, Rebecca Richards-Kortum; Automated Image Analysis of Digital Colposcopy for the Detection of Cervical Neoplasia. J Biomed Opt. 2008 Jan-Feb;13(1):014029. PMID: 18315387
Autofluorescence and diffuse reflectance spectroscopy of oral epithelial tissue using a depth-sensitive fiber-optic probe
Darren Roblyer, Rebecca Richards-Kortum, Cristina Kurachi, Konstantin Sokolov, Adel K. El-Naggar, Michelle D. Williams, Ann M. Gillenwater; A multispectral optical imaging device for in vivo detection of oral neoplasia. J Biomed Opt. 2008 Mar-Apr;13(2):024019. PMID: 18465982
Sonia Kumar, Nathan Harrison, Rebecca Richards-Kortum, Konstantin Sokolov "Plasmonic Nanoparticles with Affinity and Delivery Functionalities for Imaging Intracellular Biomarkers in Live Cells: Actin in Cultured Fibroblasts." Nanoletters, 7(5) (2007 May): 1338-43.
Kelloff GJ, Sullivan DC, Baker H, Clarke LP, Nordstrom R, Tatum JL, Dorfman GS, Jacobs P, Berg CD, Pomper MG, Birrer MJ, Tempero M, Higley HR, Petty BG, Sigman CC, Maley C, Sharma P, Wax A, Ginsberg GG, Dannenberg AJ, Hawk ET, Messing EM, Grossman HB, Harisinghani M, Bigio IJ, Griebel D, Henson DE, Fabian CJ, Ferrara K, Fantini S, Schnall MD, Zujewski JA, Hayes W, Klein EA, DeMarzo A, Ocak I, Ketterling JA, Tempany C, Shtern F, Parnes HL, Gomez J, Srivastava S, Szabo E, Lam S, Seibel EJ, Massion P, McLennan G, Cleary K, Suh R, Burt RW, Pfeiffer RM, Hoffman JM, Roy HK, Wang T, Limburg PJ, El-Deiry WS, Papadimitrakopoulou V, Hittelman WN, MacAulay C, Veltri RW, Solomon D, Jeronimo J, Richards-Kortum R, Johnson KA, Viner JL, Stratton SP, Rajadhyaksha M, Dhawan A; Workshop Program Committee "Workshop on imaging science development for cancer prevention and preemption." Cancer Biomark, 3(1) (2007): 1-33.
JM Kneller, W Lam, M Marra, M. Follen, R Richards-Kortum, C MacAulay, SJM Jones "Using SAGE to establish biomarkers of cervical cancer amenable to optical contrast agent labelling." Biomarker Insights (2007).(Submitted)
Pikkula BM, Shuhatovich O, Price RL, Serachitopol DM, Follen M, McKinnon N, MacAulay C, Richards-Kortum R, Lee JS, Atkinson EN, Cox DD "Instrumentation as a source of variability in the application of fluorescence spectroscopic devices for detecting cervical neoplasia." Journal of Biomedical Optics, 12(3) (May/June, 2007).
Aaron J, Collier T, Park SY, Coghlan L, Follen M, Richards-Kortum R, Sokolov K "Plasmon Resonance Coupling of Metal Nanoparticles for Molecular Imaging of Carcinogenesis In Vivo." Journal of Biomedical Optics, 12(3) (May-Jun 2007): 034007.
R. A. Schwarz, D. Arifler, S. K. Chang, I. Pavlova, I. A. Hussain, V. Mack, B. Knight, A. M. Gillenwater, R. Richards-Kortum "Ball lens coupled fiber optic probe for depth-resolved spectroscopy of epithelial tissue." Optics Letter, 30(10) (May 15, 2005): 1159-1161.
Dizem Arifler, Ina Pavlova, Ann Gillenwater, Rebecca Richards-Kortum "Light Scattering from Collagen Fiber Networks: Micro-Optical Properties of Normal and Neoplastic Stroma." Biophysical Journal, 92(9) (May 1, 2007): 3260-74.
Adrian Freeberg; Dan M. Serachitopol; Nick McKinnon; Roderick L. Price; Edward N. Atkinson; Dennis D. Cox; Calum E. MacAulay; Rebecca R. Richards-Kortum; Michelle Follen; Brian M. Pikkula "Fluorescence and reflectance device variability throughout the progression of a phase II clinical trial to detect and screen for cervical neoplasia using a fiber optic probe." Journal of Biomedical Optics, 12(03) (May 1, 2007).
Kester RT, Tkaczyk T, Descour MR, Christenson T, Richards-Kortum R "High NA Microendoscope Objective for a Fiber Confocal Reflectance Microscope, Optics Express." , 15(5) (March 2007): 2409-2420.
Tom Collier, Anais Malpica, Michele Follen, Rebecca Richards-Kortum "Real Time Reflectance Confocal Microscopy: Comparison of Two Dimensional Images and Three Dimensional Image Stacks for Detection of Cervical Precancer." Journal of Biomedical Optics, 12(2) (Mar-April 2007): 024021.
Richards-Kortum R, Buckley D, Schwarz RA, Atkinson EA, Follen M "A Translational Bioengineering Course Provides Substantial Gains in Civic Scientific Literacy." Annals of Biomedical Engineering, 35(8) (Aug 2007): 1324-32.
K. Carlson, Matthew Chidley, Kung-Bin Sung, Michael Descour, Ann Gillenwater, Michele Follen, Rebecca Richards-Kortum "In Vivo Fiber-Optic Confocal Reflectance Microscope With Injection-Molded Plastic Miniature Objective Lens." Applied Optics, Volume 44 (April 2005): 1792-1797.
N. Thekkek, and R. Richards-Kortum; Optical Imaging for Cervical Cancer Detection: Solutions for a Continuing Global Problem, Nature Reviews Cancer, published online 14 August 2008; doi:10.1038/nrc2462
D. J. Javier, N. Nitin, M. Levy, A. Ellington, R. Richards-Kortum; Aptamer-targeted gold nanoparticles as molecular-specific contrast agents for reflectance imaging, in press, Bioconjugate Chemistry, 175. D. J. Javier, N. Nitin, M. Levy, A. Ellington, R. Richards-Kortum; Aptamer-targeted gold nanoparticles as molecular-specific contrast agents for reflectance imaging, in press, Bioconjugate Chemistry, 2008 Bioconjug Chem. 2008 May 31. PMID: 18512972.. 2008 May 31. PMID: 18512972.
Nitin N., Michelle Williams, A. Gillenwater, Rebecca Richards-Kortum; Widefield and high resolution optical molecular imaging of EGFR expression to improve detection of oral neoplasia, submitted to Oral Oncology, 2008
A. Shadeo, R. Chari, K. M Lonergan, A. Pusic, D. Miller, T. Ehlen, D. Van Niekerk, J. Matisic, R. Richards-Kortum, M. Follen, M. Guillaud, W.L. Lam, C. MacAulay; Up regulation in gene expression of chromatin remodelling factors in cervical intraepithelial neoplasia, BMC Genomics 2008, 9:64doi:10.1186/1471-2164-9-64
Ina Pavlova, Michelle Williams, Adel El-Naggar; Rebecca Richards-Kortum; Ann Gillenwater; Understanding the biological basis of autofluorescence imaging for oral cancer detection: High resolution fluorescence microscopy in viable tissue, Clin Cancer Res. 2008 Apr 15;14(8):2396-404. PMID: 18413830
I. Pavlova, R. Schwarz, M. Williams, A. El-Naggar, A. Gillenwater, R. Richards-Kortum; Understanding Depth-Selective Fluorescence Spectroscopy of Normal, Inflammatory and Neoplastic Oral Tissue: The Role of Monte Carlo Modeling with Tissue-Specific Optical Properties, in press, Journal of Biomedical Optics, June 2008
Kortum P, Edwards C, Richards-Kortum R; The Impact of Inaccurate Internet Health Information in a Secondary School Learning Environment. J Med Internet Res 2008;10(2):e17; http://www.jmir.org/2008/2/e17/
D. L. Nida, N. Nitin, W. W. Yu, V. L. Colvin and R Richards-Kortum; Photostability of Quantum dots with varied surface passivation strategies, Nanotechnology 19 (2008) 035701
Mark C. Pierce, David J. Javier, and Rebecca Richards-Kortum, "Optical contrast agents and imaging systems for detection and diagnosis of cancer," Int. J. Cancer: 123, 1979¿1990 (2008).
D. Roblyer, C. Kurachi, V. Stepanek , M. Williams, A. El-Naggar, J. Jack Lee, A. Gillenwater, R. Richards-Kortum, "Objective Detection and Delineation of Oral Neoplasia Using Autofluorescence Imaging," submitted, Cancer Prevention Research, 2008
R.A. Schwarz, W. Gao, C.R. Weber, C. Kurachi, J.J. Lee, A.K. El-Naggar, R. Richards-Kortum, and A.M. Gillenwater, ¿Noninvasive evaluation of oral lesions using depth-sensitive optical spectroscopy,¿ Cancer, in press, June, 2008
N. M. Marín, N. MacKinnon, C. MacAulay, S. K. Chang, E. N. Atkinson, D. Cox, D. Serachitopol, M. Follen, R. Richards-Kortum "Calibration standards for multi-center clinical trials of fluorescence spectroscopy for in vivo diagnosis." Journal of Biomedical Optics, 11 (1), 014010 (2006).
Chang SK, Marin N, Follen M, Richards-Kortum R "Analysis of Clinical Fluorescence Spectroscopy For In Vivo Detection of Intraepithelial Neoplasia." Journal of Biomedical Optics, 11:2 024008 (2006): 12.
Collier T, Malpica A, Follen M, Richards-Kortum R "Sources of Scattering in Cervical Tissue: Determination of the Scattering Coefficient Using Confocal Microscopy." Applied Optics, 44 (2005): 2072-81.
T. Collier, Anais Malpica, Michele Follen, Rebecca Richards-Kortum "Real Time Reflectance Confocal Microscopy: Comparison of Two Dimensional Images and Three Dimensional Image Stacks for Detection of Cervical Precancer." Cancer Research (2005).(Submitted)
A..J, Collier T, Park SY, Coghlan L, Follen M, Richards-Kortum R, Sokolov K "Plasmon Resonance Coupling of Metal Nanoparticles for Molecular Imaging of Carcinogenesis In Vivo." Nature Medicine (2005).(In Revision)
M. Rahman, Muhammad Abdel-El-Barr, Vivian Mack, Tomasz S. Tkaczyk, Konstantin Sokolov, Michael Descour, Rebecca Richards-Kortum "Optical imaging of cervical pre-cancer with structured illumination: An interegrated approach." Gynecologic Oncology (2005).(In Press)
Zuluaga AF ; Follen M ; Boiko I ; Malpica A ; Richards-Kortum R "Optical coherence tomography: A pilot study of a new imaging technique for noninvasive examination of cervical tissue." American Journal of Obstetrics and Gynecology, 193(1) (2005): 83-8.
Follen M, Crain S, Macaulay C, Basen-Engquist K, Cantor SB, Cox D, Atkinson EN, Mackinnon N, Guillaud M, Richards-Kortum R "Optical Technologies for Cervical Neoplasia: Update of an NCI Program Project Grant." Clin Adv Hematol Oncol, 3 (2005): 41-53.
I.V. Turchin, Ekaterina A. Sergeeva, Lev S. Dolin, Natalia M. Shakhova, Rebecca Richards-Kortum "Novel algorithm of processing Optical Coherence Tomography images for differentiation of biological tissue pathologies." Journal of Biomedical Optics (2005).(In Press)
Follen M, Richards-Kortum R "New Pathways to Educate Future Translational Researchers: Foundations for Undergraduates." Lancet (2005).(Submitted)
S. Y. Park, K. Sokolov, T. Collier, J. Aaron, M.. Markey, N. Mackinnon, C. MacAulay L. Coghlan A. Milbourne, M. Follen, R. Richards-Kortum "Multispectral digital microscopy for in vivo detection of oral neoplasia in the hamster cheek pouch model of carcinogenesis." Optics Express, 13 (2005): 749-762.
Ted C. Chu, Felice Shieh, Laura A. Lavery, Matthew Levy, Rebecca Richards-Kortum, Brian A. Korgel, Andrew D. Ellington "Labeling Tumor Cells With Fluorescent Nanocrystal-Aptamer Bioconjugates." Nano Letters (2005).(Submitted)
Nida D, Rahman M, Carlson K, Richards-Kortum R, Follen M "Fluorescent Nanocrystals for Use in Early Cervical Cancer Detection." Gynecologic Oncology (2005).(Submitted)
M. D. Chidley, Kristen D. Carlson, Michael R. Descour, Rebecca R. Richards-Kortum "Design, assembly, and optical-bench testing of a high numerical aperture miniature injection-molded objective for fiber-optic confocal reflectance microscopy." Applied Optics (2005).(Submitted)
D. Arifler, R. A. Schwarz, S. K. Chang, R. Richards-Kortum "Depth-resolved reflectance spectroscopy for diagnosis of epithelial pre-cancer: model-based analysis of fiber-optic probe designs to deconvolve spectral information from epithelium and stroma." Applied Optics, Volume 44 (2005): 4291-4305.
Sung K. Chang, Yvette N. Mirabal, Edward Neely Atkinson, Dennis Cox, Anais Malpica, Michele Follen, and Rebecca Richards-Kortum "Combined Fluorescence and Reflectance Spectroscopy for in vivo Detection of Cervical Pre-cancer." Journal of Biomedical Optics, 10(2) (2005): 2-31.
Chang SK, et al "Analysis of Clinical Fluorescence Spectroscopy For In Vivo Molecular Detection of Intraepithelial Neoplasia." Journal of Biomedical Optics (2005).(In Press)
Luck B, Bovik AC, Richards-Kortum R "An Image Model and Segmentation Algorithm for Reflectance Confocal Images of in vivo Cervical Tissue." IEEE Trans Image Processing, 14 (2005): 1265-1276.
Richards-Kortum R, Buckley D, Schwarz RA, Atkinson EA, Follen M "A Translational Bioengineering Course Provides Substantial Gains in Civic Scientific Literacy." JAMA (2005).(Submitted)
E.R. Hsu, A. M. Gillenwater, R. R. Richards-Kortum "A Simple, Inexpensive Fluorescence Spectroscopy System and Contrast Agent for Detection of the Molecular Changes Associated with Oral Cancer in Living Tissue." Applied Spectroscopy, 59 (2005): 1166-1173, 2005.
A. Milbourne, S. Y. Park, L. Benedet, A. Malpica, E. N. Atkinson, M. Markey, R. Richards-Kortum, M. Follen "A Pilot Study of Multispectral Digital Colposcopy for the in vivo Detection of Cervical Intraepithelial Neoplasia." Gynecologic Oncology (2005).(In Press)
Timothy J. Muldoon, Mark C. Pierce, Dawn L. Nida, Michele Williams, Ann Gillenwater, and Rebecca Richards-Kortum "Subcellular resolution molecular imaging within living tissue by fiber microendoscopy." PNAS (2007).(Submitted)
Alicia L. Carlson, Ann Gillenwater, Adel El-Naggar, Michelle Williams, Rebecca Richards-Kortum "Real-time Confocal Microscopy and Molecular-Specific Optical Contrast Agents for the Detection of Oral Neoplasia." Technology in Cancer Research and Treatment (2007).(In Press)
N. Nitin, David J. Javier and Rebecca Richards-Kortum "Oligonucleotide Functionalized Metallic Nanoparticles as a Platform for Molecular Targeted Contrast Agents." Bioconjugate Chemistry (2007).(In Press)
Sokolov K, Nida D, Descour M, Lacy A, Levy M , Hall B, Dharmawardhane S, Ellington A, Korgel B, Richards-Kortum R "Molecular optical imaging of therapeutic targets of cancer." Adv Cancer Res, 96 (2007): 299-344.
Nitin Nitin, David J. Javier, and Rebecca Richards-Kortum "Metal Nanoparticles: Spectrally-tuned Contrast Agents for Molecular Specific Optical Reflectance Imaging." Journal of Biomedical Optics (2007).(In Press)
Rahman, M, Gillenwater A, Richards-Kortum R "Low-Cost, Multi-Modal, Portable Screening System for Early Detection of Oral Cancer." Journal of Biomedical Optics: Letters (2007).(Submitted)
H-J Shin, M C Pierce, D Lee, H Ra, O Solgaard, and R Richards-Kortum "Fiber-optic confocal microscope using a MEMS scanner and miniature objective lens." Opt Express, 15(15) (2007): 9113-9122.
Alicia L. Carlson, Lezlee Coghlan, Ann Gillenwater, and Rebecca Richards-Kortum "Dual-mode Reflectance and Fluorescence Near Real-Time Confocal Microscope for Architectural, Morphological, and Molecular Imaging of Tissue." Journal of Microscopy (2007).(In Press)
Sun Young Park, Michele Follen, Andrea Milbourne, Helen Rhodes, Anais Malpica, Nick MacKinnon, Calum MacAulay, Mia Markey, Rebecca Richards-Kortum; "Automated Image Analysis of Digital Colposcopy for the Detection of Cervical Neoplasia." Journal of Biomedical Optics (2007).(Submitted)
Gillenwater A, Papadimitrakopoulou V, Richards-Kortum R "Oral Premalignancy: New Methods of Detection and Treatment." Curr Oncol Rep, 8(2) (2006 Mar): 146-54.
Rogers JD, Tkaczyk TS, Descour MR, Karkkainen AH, Richards-Kortum R "Removal of ghost images by using tilted element optical systems with polynomial surfaces for aberration compensation." Opt Lett, 31 (4) (2006 Feb 15): 504-6.
Ted C. Chu, Felice Shieh, Laura A. Lavery, Matthew Levy, Rebecca Richards-Kortum, Brian A. Korgel, Andrew D. Ellington "Labeling Tumor Cells With Fluorescent Nanocrystal-Aptamer Bioconjugates." Biosensors and Bioelectronics, 15:21 (10) (2006 April): 1859-66.
Dizem Arifler, Calum MacAulay, Michele Follen, and Rebecca Richards-Kortum "Spatially Resolved Reflectance Spectroscopy for Diagnosis of Cervical Pre-Cancer: Monte Carlo Modeling and Comparison to Clinical Measurements." Journal of Biomedical Optics (2006).(In Press)
Kristen Maitland, Hyun Joon Shin, Hyejun Ra, Daesung Lee, Olav Solgaard, Rebecca Richards-Kortum "Single fiber confocal microscope with a two-axis gimbaled MEMS scanner for cellular imaging." Optics Express, 14 (2006): 8604-8612.(In Press)
Hsu, E.R., A.M. Gillenwater, M.Q. Hasan, A.K. El-Naggar, M.D. Williams, and R.R. Richards-Kortum "Real-time detection of epidermal growth factor receptor expression in fresh oral cavity biopsies using a molecular-specific contrast agent." Int. J Cancer, 118 (2006): 3062-3071.
Tom. Collier, Anais Malpica, Michele Follen, Rebecca Richards-Kortum "Real Time Reflectance Confocal Microscopy: Comparison of Two Dimensional Images and Three Dimensional Image Stacks for Detection of Cervical Precancer." Optics Express (2006).
Kumar S, Richards-Kortum R "Optical Molecular Imaging Agents for Cancer Diagnostics and Therapeutics." Nanomedicine, 1(1) (2006): 23-30.
Optical Kumar K, Hoshino K, Shin H,Richards-Kortum R, Zhang X "High-reflectivity Two-Axis Vertical Combdrive Microscanners for Sub-Cellular Scale Confocal Imaging Applications." MEMS, 06 (2006).(In Press)
Carlson A.L., M. Hoffmeyer, K.M. Wall, P.J. Baugher, R. Richards-Kortum "Development of a Macroscopic Fluorescence Imaging System for In Situ Analysis of Human Breast Cancer Progression in Murine Models." Lasers in Surgery and Medicine (2006).(In Press)
M. D. Chidley, K. D. Carlson, R. R. Richards-Kortum, and M. R. Descour "Design, assembly, and optical bench testing of a high-numerical-aperture miniature injection-molded objective for fiber-optic confocal reflectance microscopy." Appl. Opt, 45 (2006): 2545-2554.
Kristen D. Carlson, Ann M. Gillenwater, Michelle Williams, Adel K. El-Naggar, Michael Descour, Rebecca R. Richards-Kortum "Confocal Reflectance Microscopy for Detection of Oral Cavity Neoplasia In Vivo." Clinical Cancer Research (2006).(Submitted)
Presentations
Conference Committee Member
"Translational Optical Molecular Imaging: Nano to Macro." Rice University, . (2007)
"Global Health Challenges Symposium." Texas Medical Center. (2007)
"Career Success Workshop for Women in Science and Engineering." Rice University, . (2007)
Richards-Kortum R, Global Cancer Prevention: Role of Molecular Imaging, Koch Cancer Biology Symposium, MIT, July, 2008
"TAMEST Annual Meeting." TAMEST Annual Meeting, Houston, TX. (May, 2008)
Invited Talk
"Cellular labeling of SiHa and oral biopsies with quantum dot bioconjugates." SPIE Photonics West Biomedical Optics, . (January 2005) With Nida D, Hsu E, Shieh F, Korgel B, Follen M, Sokolov K Richards-Kortum K.
"Engineering Sustainable Innovations to Prevent Disease." AIMBE Annual Meeting, . (2/2008)
Roblyer D, Gillenwater AM, Richards-Kortum R, "Detection of Oral Neoplasia Using In Vivo Multispectral Optical Imaging", Optical Society of America (OSA) topical meeting, Biomed, St. Petersburg, Florida, March, 2008, Oral Presentation
"High resolution Optical Imaging of Pre-Cancers with Structured Illumination: An Integrated Approach." HSEMB Conference, Micro- and Nano-technology, Houston. (February 2005) With Mohammed Rahman, Tomasz S. Tkaczyk, Konstantin Sokolov, Michael Descour, Rebecca Richards-Kortum.
"Novel Microscopy for Early Detection of Cancer, Gordon Research." Conference New Frontiers In Cancer Detection & Diagnosis, Buellton, CA, January, 2005. (Buellton, CA, January, 2005) With Richards-Kortum R.
Richards-Kortum R, Rice 360: Institute for Global Health Technologies, Rice Alliance, January, 2008
"Bioengineering Clinical Internships." AAAS Meeting, Washington. (February, 2005) With Richards-Kortum R.
M. Rahman, A. Gillenwater, R. Richards-Kortum; ¿Lost-cost screening system for early detection of oral cancer using optical imaging technology¿. International Socio-Scientific Cancer Conference, March 21-24, 2008, Dhaka, Bangladesh
Thekkek N, Valle B, Maru D, Anandasabapathy S, Richards-Kortum R. "Developing Optical Biomarkers to Characterize the Progression of Barrett's Esophagus to Pre-Cancer" Optical Society of America BIOMED 2008, St. Petersburg , Florida
"Optical Molecular Imaging." Molecular Medicine Symposium, Houston, TX. (February 2005) With Richards-Kortum R.
"Quantum Dot Conjugates: An Evaluation of Passivation Strategies." SPIE Photonics West Biomedical Optics, . (January 2007) With Nida D, Nitin N, Yu W, Colvin V.
"Fiber Optic Confocal Microscope: In Vivo Pre-Cancer Detection." Carnegie Mellon University, . (April 13, 2005) With Carlson K.
Richards-Kortum R; "Optical Molecular Imaging for Cancer Screening:
Translational Challenges", Invited Plenary Presentation, Optical Society of America BIOMED 2008, St. Petersburg , Florida
Richards-Kortum R, Early Detection of Oral Cancer Using Optical Molecular Imaging, BME Departmental Seminar, UC Davis, May, 2008
"High resolution Optical Imaging of Pre-Cancers with Structured Illumination: An Integrated Approach." CLEOS/QELS, Fluorescence-based Diagnostics, Baltimore. (May 2005) With Mohammed Rahman, Tomasz S. Tkaczyk, and Konstantin Sokolov, Jeremy D. Rogers, Rebecca Richards-Kortum.
Abstract appears in: Acta Cytologica 51 (2): 265-265 Suppl. S, Mar-Apr 2007
"Fiber Optic Reflectance Confocal Imaging: In Vivo Detection of Cervical Dysplasia." European Conference on Biomedical Optics, . (June 2005) With Carlson K, Sung KB, Luck B, Descour M, Follen M, Richards-Kortum R.
"Optical Molecular Imaging for Point of Care Diagnostics: Global Applications." ECI Conference on Advances in Optics for Biotechnology, Medicine, and Surgery, Naples, Florida. (June 2007)
"Fiber Optic Reflectance Confocal Imaging: In Vivo Detection of Dysplasia." Institute of Biomedical Optics, University of Luebeck, . (June 2005) With Carlson K.
"Metallic nanoparticles as molecular-specific contrast agents for in-vivo optical imaging of dysplasia." American Society for Photobiology, Annual Meeting, . (July 2006) With D. Javier, N. Nitin, and R. Richards-Kortum.
Richards-Kortum R, Molecular Imaging of Oral Neoplasia, MD Anderson Symposium on Pathology of the 21st Century, May, 2008.
Richards-Kortum R, New Solutions to Prevent Disease in Vulnerable Populations, Rushmer Lecture, University of Washington, June, 2008
"WARNING: Insufficient Bioengineering Education
Can Be Hazardous to Your Health." Platform Presentation, Whitaker Foundation Educational Summit, Washington, DC. (March, 2005) With Richards-Kortum R.
"Optical Molecular Imaging of Cancer." 58th Annual Symposium on Fundamental Cancer Research, Houston, TX. (October, 2005) With Richards-Kortum, R.
Leautaud V, Javier D, Sutton RE, Richards-Kortum R: Point of care diagnostics of HIV-1 viral loads using nano-based reagents and isothermal PCR. In Enabling Point-of-Care Diagnostics. Washington, D.C.: Cambridge Healthtech Institute; 2008
"Reflectance and Fluorescence imaging of Pre-Cancer with Structured Illumination- An Integrated Approach." Frontiers in Optics, Emerging Technologies, Tucson. (October 2005) With Mohammed Rahman, Tomasz S. Tkaczyk, and Konstantin Sokolov, Michael Descour, Rebecca Richards-Kortum.
Rosbach, KJ, Richards-Kortum, R, Peek, K. Doctoral bioengineering students learn about cancer by studying patient cases. 2008 BMES Annual Fall Meeting; St. Louis, MO.
"Optical Molecular Imaging for Early Cancer Detection." AACR Molecular Diagnostics Meeting, . (September, 2006)
"Optical Molecular Imaging for Early Detection of Cervical Cancer." NTROI Symposium, . (November, 2005) With Richards-Kortum R.
"In Vivo High Resolution Imaging for Pre-Cancer Detection." Fifth Inter-Institute Workshop on Optical Diagnostic Imaging from Bench to Bedside at the National Institutes of Health, . (September, 2006)
"Molecular Imaging of Cancer, MD/PhD Seminar Series." Baylor College of Medicine, Houston, TX. (April, 2005) With Richards-Kortum R.
Richards-Kortum R, The Rewards of Leadership, Invited Presentation, 2008 BMES Annual Fall Meeting; St. Louis, MO.
Richards-Kortum R, Bioengineering Applications to Address Global Health, Duke University, November, 2008
"Cadaver-based clinical anatomy: Extending the frontier of BME education." BMES Annual Meeting, . (October, 2006) With Kathryn E. Peek, Michele Follen, Rebecca Rae Richards-Kortum.
"Optical Imaging for Early Detection of Cancer, New Faculty Seminar." Rice University, Houston, TX. (September, 2005) With Richards-Kortum R.
"Med Into Grad: Translational BIOE for Cancer Diagnostics and Therapeutics." BMES Annual Meeting, . (October, 2006) With Rebecca Rae Richards-Kortum, Michele Follen.
Richards-Kortum R, Rice 360: Institute for Global Health Technologies, Homecoming Weekend Talk, Rice University, November, 2008
"Translational Undergraduate Education." HST 35th Annual Reunion, Cambridge, MA,. (September, 2005) With Richards-Kortum R.
Richards-Kortum R, Low Cost Tools for Oral Cancer Screening, NIBIB Meeting on Low Cost Diagnostic Tools, Hyderabad, India, November, 2008
"Optical Molecular Imaging of Cancer, Something New for Lunch." Rice University, Houston, TX. (October, 2005) With Richards-Kortum, R.
"Bioengineering Educational Initiatives." Rice University, Engineering Alumni Association, Houston, TX. (October, 2005) With Richards-Kortum R.
"Optical Spectroscopy for the Detection of Oral Cancer." SPIE Photonics West, San Jose, CA,. (January 2007) With D. Daye, R. Schwarz, R. Richards-Kortum, and A. Gillenwater.
"Molecular Imaging of Cancer." Whitaker Foundation Symposium on Advances in Nanobiotechnology, Rice University, Houston, TX. (October, 2005) With Richards-Kortum R.
"Optical Molecular Imaging, Cancer Imaging Seminar Series." British Columbia Cancer Agency, . (October, 2005) With Richards-Kortum R.
"Optical Molecular Imaging of Cancer, Grand Rounds." Baylor College of Medicine, Housston, TX. (November, 2005) With Richards-Kortum, R.
Keynote Speaker
"Warning: Insufficient Bioengineering Education Can Be Hazardous to Your Health." Houston Society for Engineering in Medicine and Biology. (February, 2006)
Other
"In Vivo Fiber Confocal Microscopy for Detection of Oral Cavity Neoplasia." OSA Topical Meeting on Biomedical Optics, . (March 2006) With Carlson K., A. Gillenwater, M. Williams, A. El-Naggar, R. Richards-Kortum.
"Depth Sensitive Optical Spectroscopy for Noninvasive Detection of Oral Cavity Neoplasia." OSA Topical Meeting on Biomedical Optics, . (March 2006) With Schwarz R., R. Richards-Kortum, A. Gillenwater.
"MEMS Based Single Fiber Reflectance Confocal Microscope System (SFCM) for In Vivo Cellular Imaging." OSA Topical Meeting on Biomedical Optics, . (March 2006) With Shin H.J., K. Carlson, H. Ra, D. Lee, O. Solgaard, R. Richards-Kortum.
"Single Fiber Confocal Microscope Using a Two-Axis Microscanner for Cellular Imaging." CLEO, . (May 2006) With Carlson K., H.J. Shin, H. Ra, D. Lee, O. Solgaard, R. Richards-Kortum.
"Sustainable Water Purification for the Developing World: Multidisciplinary Education for the International Engineer." Association of Environmental Engineering and Science Professors Conference entitled Interactions at the Interface Making the Connections Between Environments, Disciplines and Nations, . (2007) With Gordon R, Dyer M, Preidis G, Alvarez P.
"A Multimodal Imaging Device for Detection of Oral Neoplasia." ECI conference Advances in Optics for Biotechnology, Medicine, and Surgery X, Naples, Florida. (June 2007) With Darren Roblyer, Kurachi C, Gillenwater A, Sokolov KV, El-Naggar A, Williams M.
"Dual reflectance and fluorescence confocal microscope for near real-time morphological and molecular imaging of tissue." The Fifth Annual Meeting of the Society for Molecular Imaging, Waikoloa HI. (August 2006) With Carlson A., Gillenwater A., and Richards-Kortum R.
"A Multimodal Imaging Device for Detection of Oral Neoplasia Translational Optical Molecular Imaging: Nano to Macro." Rice University, Houston, TX. (May 2007) With Darren Roblyer, Kurachi C, Gillenwater A, Sokolov KV, El-Naggar A, Williams M.
"Optical Diagnostics for Oral Health Greater Houston Dental Hygienists Society Professional Education meeting for Continuing Education Credit." Houston, TX. (September 2007) With Darren Roblyer,Martinez J,Nitin N,Muldoon T,Rahman M,Schwarz R,Rosbach K,Thekkek N,Tkaczyk T,Javier D, Sokolov K, Follen M, Gillenwater A, Descour M, Adewole I.
Poster
"Optical Detection of Intracellular hTERT using Molecular-specific Contrast Agents." Gordon Conference on Lasers in Medicine, . (July, 2006) With A.L. van de Ven, K Adler-Storthz, R Richards Kortum.
"Metal Nanoparticles Based Multi-spectral Reflectance Contrast Agents for Molecular Imaging." Gordon Conference, . (July, 2006) With Nitin Nitin, David J. Javier, Rebecca Richards-Kortum.
"Metal Nanoparticle Based Spectrally Tuned Contrast Agents for Molecular Specific Optical Reflectance Imaging in Neoplasia." Society of Molecular Imaging Annual Meeting, . (Aug 2006) With Nitin Nitin, David J. Javier, Rebecca Richards-Kortum.
David J. Javier; Robert Kester; Veronica Leataud; Tomasz Tkaczyk; Rebecca Richards-Kortum. ¿Point-of-care detection of infectious diseases using novel opto-nano technologies¿ (poster presentation). ¿Keystone Symposia: Translating New Technologies to Improve Public Health in Africa¿. May 15-20, 2008. Kampala, Uganda
"Cost Effective Digital Imaging Aid for Early Detection of Cervical Neoplasia." ECI Conference on Advances in Optics for Biotechnology, Medicine, and Surgery, Naples, Florida. (June 2007) With J. Martinez, N. Thekkek, I. Adewole, C. MacAuley, M. Follen.
"High Resolution Fiber Microendoscopy." ECI Conference on Advances in Optics for Biotechnology, Medicine, and Surgery, Naples, Florida. (June 2007) With Muldoon T.
"Optical Detection of Intra-Cellular Cancer Biomarkers." Gordon Research Conference, Lasers in Medicine and Biology, Plymouth, NH. (2-7 July, 2006) With Sonia Kumar, Rebecca Richards-Kortum, Konstantin Sokolov.
"Digital Imaging Aid for Early Detection of Cervical Cancer in Low Resource Settings." Biomedical Engineering Society 2007 Annual Fall Meeting, Los Angeles, California.. (September 2007) With N. Thekkek, J. Martinez, I. Adewole, C. MacAuley, M. Follen.
"High resolution Imaging of Deep Tissue Structures with an Image Guide Microscope." Society of Molecular Imaging Annual Meeting, . (August 2006) With T. Muldoon, R. Richards-Kortum.
"Oligonucleotide gold nanoparticles as scaffold for development of molecular imaging contrast agents." Biomedical Engineering Society 2007 Symposium, Los Angeles, CA. (2007) With David J. Javier, Nitin Nitin.
"New course prepares doctoral BME students for translational cancer research careers." Biomedical Engineering Society 2007 Symposium, Los Angeles, CA. (2007) With Peek K, Follen M.
"Global Health Technology Design Woven into Many Levels of Design Courses." Biomedical Engineering Society 2007 Symposium, Los Angeles, CA. (2007) With Oden M, Mirabal Y.
Session Chair
"Engineering Foundation Conference on Future Directions of Lasers in Medicine and Surgery." Optical Spectroscopy Session, . (July, 2007)
"NIBIB Meeting on Point of Care Diagnostics." Washington, DC,. (April, 2006)
Theses
Mohammed Rahman, "Bioengineering." (2006).(Thesis or Dissertation Director)
Ina Pavlova, "Bioengineering." (2006).(Thesis or Dissertation Director)
Sun Park, "Bioengineering." (2006).(Thesis or Dissertation Director)
Dawn Nida, "Bioengineering." (2006).(Thesis or Dissertation Director)
Alicia Lacy, "Bioengineering." (2006).(Thesis or Dissertation Director)
Kristen Carlson, "Biomedical Engineering." (2006).(Thesis or Dissertation Director)
Wendy Mayes, "Bioengineering." (2006).(Thesis or Dissertation Director)
Jair Martinez, "Bioengineering." (2006).(Thesis or Dissertation Director)
Darren Roblyer, "Bioengineering." (2006).(Thesis or Dissertation Director)
, "Bioengineering." (2006).(Thesis or Dissertation Director)
Tim Muldoon, "Bioengineering." (2006).(Thesis or Dissertation Director)
Wendy Mayes, "Bioengineering." (2006).(Thesis or Dissertation Director)
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